1/ New data in the last day on how well natural immunity and vaccine-induced immunity protect us against the Delta variant.
Here's the take-home message:
2 doses of Pfizer or Moderna vaccine will protect you,
even against the Delta variant.
Here's the take-home message:
2 doses of Pfizer or Moderna vaccine will protect you,
even against the Delta variant.
2/ Published in the @NEJM
nejm.org/doi/full/10.10…
Delta is 2.4-3.3x less susceptible to neutralizing Abs elicited by prior infection or Pfizer/Moderna vaccination as compared to the early WA1/2020 variant.
The dotted line represents protective immunity.
nejm.org/doi/full/10.10…
Delta is 2.4-3.3x less susceptible to neutralizing Abs elicited by prior infection or Pfizer/Moderna vaccination as compared to the early WA1/2020 variant.
The dotted line represents protective immunity.
3/ Published in @Nature:
nature.com/articles/s4158…
Left:
Low neutralizing antibody (nAbs) levels by 12 months after natural infection
4x decrease in nAbs vs Beta & Delta compared to Alpha
Right:
Dramatic bump in nAbs levels if vaccinated after infection, including vs Beta & Delta
nature.com/articles/s4158…
Left:
Low neutralizing antibody (nAbs) levels by 12 months after natural infection
4x decrease in nAbs vs Beta & Delta compared to Alpha
Right:
Dramatic bump in nAbs levels if vaccinated after infection, including vs Beta & Delta
4/ nature.com/articles/s4158…
Left: nAbs 3 weeks after Pfizer
Right: nAbs 8 weeks after Pfizer (i.e. 5 weeks after 2nd dose)
You need the second dose to assure neutralization versus Beta & Delta.
The dotted line represents limits of detection.
Left: nAbs 3 weeks after Pfizer
Right: nAbs 8 weeks after Pfizer (i.e. 5 weeks after 2nd dose)
You need the second dose to assure neutralization versus Beta & Delta.
The dotted line represents limits of detection.
5/ nature.com/articles/s4158…
12m after infection:
50% neutralizers vs Beta variant
47% neutralizers vs Delta variant
12m after infection + vaccination:
100% neutralizers vs all variants
Natural infection alone doesn't protect vs variants.
mRNA vaccination after infection does.
12m after infection:
50% neutralizers vs Beta variant
47% neutralizers vs Delta variant
12m after infection + vaccination:
100% neutralizers vs all variants
Natural infection alone doesn't protect vs variants.
mRNA vaccination after infection does.
6/ nature.com/articles/s4158…
Week 3 after Pfizer vaccine (just prior to 2nd dose):
6% neutralize Beta
13% neutralize Delta
Week 8 after Pfizer vaccine (5 weeks after 2nd dose):
81% neutralize Beta
94% neutralize Delta
Week 3 after Pfizer vaccine (just prior to 2nd dose):
6% neutralize Beta
13% neutralize Delta
Week 8 after Pfizer vaccine (5 weeks after 2nd dose):
81% neutralize Beta
94% neutralize Delta
7/ Immunity is NOT on/off.
8/ Immunity is on a spectrum or gradient.
nAbs = neutralizing antibodies
We can overcome immune-evading variants (e.g. the Beta & Delta variants) with higher nAbs titers.
This is why you need to be vaccinated—even if you've had COVID—if you want to be protected vs variants.
nAbs = neutralizing antibodies
We can overcome immune-evading variants (e.g. the Beta & Delta variants) with higher nAbs titers.
This is why you need to be vaccinated—even if you've had COVID—if you want to be protected vs variants.
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