Soo NEJM has an educational COVID critical care “game.” Obviously I had to play on expert.
First off let’s talk about the name: Bagel Mage?!?
I’m not one to criticize - my name is just two synonymous verbs - but Bagel Mage 🥯 🧙♀️ sounds like the lamest D&D character ever.
1/
Bagel’s hypotensive with sats in the mid 80s, better do a quick assessment & start someO2.
“May I ask about your goals in the event of a cardiac or respiratory arrest?”
- maybe the worst possible way to ask this but here it goes…
…Ok I guess he’s an everything bagel. 2/
No POCUS - guess I’ll do an exam & order some tests: ABG, basic labs, procalcitonin, CXR, some cultures, & a COVID test (you know “trust but verify”)
While I’m waiting I’ll order APAP, HFNC
Ugh oh. I guess im trouble for not coding enough. Damn this simulation is realistic! 3/
Ok - I entered some ICD9 codes to get that admin off my back.
Now they are all friendly (“your expert care is needed”) and I’m allowed get back to patient care.
Start some O2, order some Abx, and fire off a CXR & some labs… 4/
Bad news: bilateral opacities on radiograph, he’s blowing off a lot of CO2 to protect oxygenation, and he’s COVID positive!
Better start some therapeutics. Ivermectin isn’t on formulary so I’ll stick to stuff that actually works: corticosteroids. 5/
Ok I must have done something right: “Probability of a Good Outcome” just went from 0.00 to 0.36
Also, why is an anesthesiology ventilator just hanging out next to the bed in the ICU? Awkward. 6/
No time to ponder the weird game artwork. This is getting serious!
“Doctor, Bagel Mage isn’t doing well”
7/
More results back: 🧪 procal +, 🧫 growing staphylococcus aureus on blood cultures. Definitely no tocilizumab… good thing I already started Abx.
Getting nervous about that rising respiratory rate… 8/
Time for some awake proning!
9/
Uh oh I’m in trouble again - “a gentle and friendly reminder” in hospital admin parlance is serious!
I need to update my differential and do more documentation. Press Ganey scores are on the line!!!
10/
Let’s reassess. We’ve tried HFNC, prone positioning, steroids, and antibiotics. Vitals and ABG look worse.
I ask a Bagel how he’s doing and he says “Bad”.
We could try NIPPV but I don’t think there is a quickly reversible cause here. Time to intubate. 11/
I tried hard to avoid intubation but ultimately it was necessary. Now Bagel is comfortably sedated on propofol and synchronous with the vent.
At least “Probability of a good outcome” is going up… 12/
I guess his nurse doesn’t agree that he’s doing better.
“Have you considered…” consulting a better doctor? Ouch.
She’s right though. All hands on deck for Bagel. Let’s see what our esteemed consultants have to say…
13/
Ok so my trusty ID consult has like 15 NEJM papers for me to consider reading…Um Thanks?
14/
Let’s try consulting pulm.
He’s just dying to tell me about the ARDSnet trial. That will make my next choice easier.
15/
Sent a CRP, D-Dimer, & ferritin to keep my consultants happy. Perhaps a fecal occult blood test to go with that?
Clinically we’re stabilized: vented on LPV, Proned, on neuromuscular blockers (I don’t like to say “paralyzed” because it sounds scary to families), inhaled EPO 16/
Speaking of stabilized - this game is super unstable running on Safari/iOS. It keeps reloading randomly.
I keep saving Bagel but then the game crashes and I have to start over…ugh 17/
The game keeps crashing & restarting. I should just do this in chrome but I’m too stubborn.
This causality loop is starting to make me go a little crazy & think insane “what if”thoughts. Should I use NS instead of LR? Dopamine instead of norepinephrine? (Like I said crazy😜) 18/
OK managed to get the game working properly in Chrome...
In fairness to NEJM, they do warn you about these stability issues in the directions.
The are also very clear that Bagel Mage is not based on any real life Bagels. They really don't want to get sued by a litigious 🥯 19/
Anyway back to the case -
Bagel seems to be oxygenating better but I'm nervous about his hypotension. It would be great to have POCUS but i'll just cast a broad net...
Oh no. Bagel's troponin in 78 (nl <0.04) and his ECG doesn't look good! 20/
Looks like a STEMI: Time for ASA, a heparin gtt, STAT echo & an urgent call to (another) consultant: interventional cards!
This consultant is all business - no NEJM papers to read - she just PCI's the left main & drops the mic. The before after angiogram speaks for itself. 21/
Starting to feel good about this. Bagel is sick but the "probability of a good outcome" meter thinks he's gonna make it.
Hospital admin thinks so too & says "we could use another bed"
If STEMI+ARDS+COVID doesn't merit an ICU bed in this (fictional) universe, what does? 22/
I guess my only choice in response to the hospital admin was "Got it!" (I must be on the fast track to promotion)
Now I get to make another high stakes decision:
- go to call room
- finish the shift
- start the day over again (another Groundhog day?)
Weird ending but OK... 23/
OK well that was interesting... this game was hokey but honestly it was also kinda enjoyable, in spite of all the crashes.
Hope you've enjoyed this weird rambling 🧵. If you want to save Bagel yourself, you can check out the NEJM site: covid19rx.nejm.org/landing/index.…
24/24
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#HurricaneHelene damaged the factory responsible for manufacturing over 60% of all IV fluids used in the US, leading to a major national shortage.
As clinicians what can we do to about the #IVFluidShortage and how can we prevent this crisis from happening again?
A thread 🧵 1/
There are many things we can do as clinicians to improve ICU care & reduce IVF use.
1️⃣Don't order Maintenance IV Fluid!
Almost no patient actually needs continuous IV fluids.
Most either need resuscitation (e.g. boluses) or can take fluid other ways (PO, feeding tube, TPN).
2/
Frequently if someone is NPO overnight for a procedure, MIVF are ordered.
This is wrong for two reasons.
We are all NPO while asleep & don't need salt water infusions!
We should be letting people drink clears up to TWO HOURS before surgery, per ASA.
New favorite physiology paper: Central Venous Pressure in Space.
So much space & cardio physiology to unpack here including:
- effects of posture, 3g shuttle launch, & microgravity on CVP
- change in the relationship between filling pressure (CVP) & LV size
- Guyton curves! 1/
To measure CVP in space they needed two things:
📼 an instrument/recorder that could accurately measure pressure despite g-force, vibration, & changes in pressure. They built & tested one!
🧑🚀👩🚀👨🚀 an astronaut willing to fly into space with a central line! 3 volunteered! 2/
The night before launch they placed a 4Fr central line in the median cubital vein & advanced under fluoro.
🚀The astronauts wore the data recorder under their flight suit during launch.
🌍The collected data from launch up to 48 hrs in orbit. 3/
Did he have a head CT? What did it show?
Did he have stitches? Tetanus shot?
The NYT ran nonstop stories about Biden’s health after the debate but can’t be bothered to report on the health of someone who was literally shot in the head?
To the people in the replies who say it’s impossible because of “HIPPA” 1. I assume you mean HIPAA 2. A normal presidential candidate would allow his doctors to release the info. This is exactly what happened when Reagan survived an assassination attempt. washingtonpost.com/obituaries/202…
My advice to journalists is to lookup tangential gunshot wounds (TGSW).
Ask questions like:
- what imaging has he had?
- what cognitive assessments?
- has he seen a neurosurgeon or neurologist?
- he’s previously had symptoms like slurred speech, abnormal gait - are these worse?
If you intubate you need to read the #PREOXI trial!
-n=1301 people requiring intubation in ED/ ICU were randomized to preoxygenation with oxygen mask vs non-invasive ventilation (NIV)
-NIV HALVED the risk of hypoxemia: 9 vs 18%
-NIV reduced mortality: 0.2% vs 1.1%
#CCR24
🧵 1/
Hypoxemia (SpO2 <85%) occurs in 10-20% of ED & ICU intubations.
1-2% of intubations performed in ED/ICU result in cardiac arrest!
This is an exceptionally dangerous procedure and preoxygenation is essential to keep patients safe.
But what’s the *BEST* way to preoxygenate? 2/
Most people use a non-rebreather oxygen mask, but because of its loose fit it often delivers much less than 100% FiO2.
NIV (“BiPAP”) delivers a higher FiO2 because of its tight fit. It also delivers PEEP & achieves a higher mean airway pressure which is theoretically helpful! 3/
Results from #PROTECTION presented #CCR24 & published @NEJM.
- DB RCT of amino acid infusion vs placebo in n=3511 people undergoing cardiac surgery w/ bypass.
- Reduced incidence of AKI (26.9% vs 31.7% NNT=20) & need for RRT (1.4% vs 1.9% NNT=200)
Potential game changer!
🧵 1/
I work in a busy CVICU & I often see AKI following cardiac surgery.
Despite risk stratification & hemodynamic optimization, AKI remains one of the most common complications after cardiac surgery with bypass.
Even a modest reduction in AKI/CRRT would be great for my patients. 2/
During cardiac surgery w/ bypass, renal blood flow (RBF) is reduced dramatically. This causes injury, especially in susceptible individuals.
But what if we could use physiology to protect the kidneys?
Renal blood vessels dilate after a high protein meal increasing RBF & GFR! 3/