"Vaccine-elicited immune responses are significantly divergent in neuro-PASC versus healthy COVID convalescents."

"T cell responses to SARS-CoV-2 mRNA vaccines are aberrantly elevated in longitudinally sampled neuro-PASC patients compared with healthy convalescents..."

1/
"The nasopharynx is not the only possible testing site, however, as there are numerous studies showing that infectious SARS-CoV-2 particles can be detected in fecal matter and can persist for up to 70 days post-symptom onset..."

2/
"GI symptoms also did not have to be present in order to test RT-PCR+ for SARS-CoV-2 in stool. Thus, it is possible that the gut may also act as a reservoir for persistent SARS-CoV-2 infection which leads to aberrant T cell responses and the development of neuro-PASC..."

3/
"The inability of CD8+ TEM to become activated by antigenic stimulation in CN patients is thus suggestive of a chronic infection state wherein viral antigen can persist but limits the formation of CD8+ T cell memory..."

4/
"The causes of ME/CFS remain elusive, and the underlying mechanisms of neuro-PASC remain similarly unknown."

Neuro-PASC patients reported significantly elevated levels of anxiety, depression, fatigue, sleep disturbance and pain as well as decreased physical function..."

5/
"The severity of these deficits was highly correlated with Ag-specific enhancements in polyfunctionality and decreases in polarization of various memory T cell subsets. It's possible that T cell function contributes to the genesis and persistence of some of these symptoms..."

6/
"Studies in mouse models of West Nile and Zika viral encephalitis have demonstrated that IFN-γ production from CD8+ T cells in the brain is responsible for neuronal apoptosis and spatial learning deficits..."

7/
🤬"These data suggest that the mRNA vaccines do not induce robust long-term T cell responses in many individuals, regardless of prior COVID exposure, if they are not neuro-post-acute sequelae patients..."🤬

8/
"Conversely, vaccination may not be indicated for long-COVID patients who might have a persistent infection as it may be ineffective in the absence of viral clearance."

medrxiv.org/content/10.110…

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More from @Harvard2H

12 Sep
☑️MUTATING ADAPTIVELY FOUR-TIMES FASTER THAN THE FLU, NOW SPREADING LIKE KARDASIAN CHEEKS IN A RAP VIDEO!!

"The association between clade growth rates and nonsynonymous mutations is highest within the S1 subunit, suggesting a positive fitness effect of S1 substitutions..."

1/
"Several of these S1 substitutions, and a handful of mutations in other genes, exhibit CONVERGENT EVOLUTION, occurring independently many times and giving rise to successful viral clades each time they do..."

2/
"This indicates that the correlation between S1 substitutions and clade success is a general feature of SARS-CoV-2 lineages.

"The metric presented here provides evidence that SARS-CoV-2 is evolving adaptively and that the predominant locus of this evolution is spike S1..."

3/
Read 6 tweets
11 Sep
🐝AIRBORNE AIDS SAYS WHAT?

"COVID-19 unhinges the immune system in ways no one expected, going so far as to turn the body against itself."

"Some people who get especially bad or unusual symptoms, for instance, harbor rogue antibodies – similar to those seen in..."

1/
"...autoimmune diseases – that disrupt the body’s normal immune response or attack its own tissues."

"Immune cells from patients with mild COVID-19 (those discharged from the hospital within a few days) were running this crucial virus-defense program without a hitch..."

2/
"But that was not the case in the immune cells from patients with severe COVID-19 (those admitted to the ICU, often with ARDS). Alarmingly, none of their cells had deployed the interferon response..."

3/
Read 14 tweets
31 Jul
🎵 Army disharmony
PLA dropped a load on us...

OPV, how can I explain it?
I'll take you frame-by-frame it
To have y'all jumpin' sha' we jabbin' it
O is for Oral, P is for Polio - scratchin' pustule?

1/
🎙️The last V... well... that's not that simple...
It's sorta like another way to call a vaccine deattenuated.

It's five little letters that I'm missin' here 🐝
You get it on occasion if the other party is a swarmin'

It seems I gotta start the explaning
Bust it 🦠

2/
You ever had a girl and met her in a public flow?
You get her name and her number and you feelin' real mellow? 🎹

You get home, wait a day, her variants all up in your house
Damn its too late motherfuckah, the swarm got you now!! 🤣
Read 5 tweets
28 Jul
You can trust an anonymous internet account that's been trying to hide the truth and steal credit (and collecting THOUSANDS of dollars), or you can trust me and my dad.

Here's how I explained it on the timeline, which I made after credit first started to be stolen...

1/ Image
"Their article is picked up by the Wayback Machine on February 1st - you can follow its evolution and verify what it got first at that link."

And by late February, still before anyone else? Let's see how many times "vaccine" shows up in search?

sutori.com/item/1-31-hara…
Oh it shows up 11 times. So yeah you morons can keep letting anonymous sock-puppets gaslight you, or you can tell the truth and save lives?

web.archive.org/web/2020022820…
Read 4 tweets
28 Jul
🦠NOT ONLY ARE THE TESTS WE'RE USING *ONLY* PICKING UP THE PART OF THE SWARM THAT LIKES LIVING IN NOSES - EVEN THOSE TESTS AREN'T TELLING US SSHHEEEEEETTT ABOUT THE NEW VARIANTS!! 🐝

"Mutations in the genome can create a challenge to obtaining accurate viral detection..."

1/
"The degree to which an assay is affected depends upon the location and type of mutation."

"For example, research describes the catastrophic failure of one RT-qPCR assay to detect the B1.1.7 variant of the SARS-CoV-2 S-gene..."

2/
"In this situation, a deletion of two amino acids from the spike protein in the B1.1.7 variant resulted in the loss of six bases, ultimately helping the virus evade detection using any RT-qPCR assay targeting that region..."

3/
Read 5 tweets
27 Jul
🐝VIVA LA SWARM!!🐝

"The first three VOCs (B.1.1.7, B.1.351 and P.1) exhibited almost twice as many changes to their genomes as other contemporaneous SARS-CoV-2 lineages, with 23 mutations characterizing B.1.1.710, 21 in B.1.35, and 23 in P.1..."

1/
"These studies have documented rapid changes to the composition of the viral population within a patient, over the course of days. These rapid changes are faster than expected by drift and point to natural selection for the virus to better beat a weakened immune system..."

2/
"Many of these mutations were found in the receptor binding domain, which is essential for host entry."

"many of these mutations are non-synonymous, consistent with selection favouring changes to the Spike protein..."

3/
Read 13 tweets

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