Richard H. Ebright Profile picture
Sep 7, 2021 10 tweets 2 min read Read on X
"NEWLY RELEASED documents provide details of US-funded research on..coronaviruses at the Wuhan Institute of Virology..The Intercept has obtained more than 900 pages of documents detailing..work of..EcoHealth Alliance..at the Chinese lab.."

interc.pt/3yN1YIj
"The trove of documents includes two previously unpublished grant proposals that were funded by the NIAID, as well as project updates relating to the EcoHealth Alliance’s research, which has been scrutinized amid increased interest in the origins of the pandemic."
The materials show that the 2014 and 2019 NIH grants to EcoHealth with subcontracts to WIV funded gain-of-function research as defined in federal policies in effect in 2014-2017 and potential pandemic pathogen enhancement as defined in federal policies in effect in 2017-present.
(This had been evident previously from published research papers that credited the 2014 grant and from the publicly available summary of the 2019 grant. But this now can be stated definitively from progress reports of the 2014 grant and the full proposal of the 2017 grant.)
The materials confirm the grants supported the construction--in Wuhan--of novel chimeric SARS-related coronaviruses that combined a spike gene from one coronavirus with genetic information from another coronavirus, and confirmed the resulting viruses could infect human cells.
The materials reveal that the resulting novel, laboratory-generated SARS-related coronaviruses also could infect mice engineered to display human receptors on cells ("humanized mice").
The materials further reveal for the first time that one of the resulting novel, laboratory-generated SARS-related coronaviruses--one not been previously disclosed publicly--was more pathogenic to humanized mice than the starting virus from which it was constructed...
...and thus not only was reasonably anticipated to exhibit enhanced pathogenicity, but, indeed, was *demonstrated* to exhibit enhanced pathogenicity.
The materials further reveal that the the grants also supported the construction--in Wuhan--of novel chimeric MERS-related coronaviruses that combined spike genes from one MERS-related coronavirus with genetic information from another MERS-related coronavirus.
The documents make it clear that assertions by the NIH Director, Francis Collins, and the NIAID Director, Anthony Fauci, that the NIH did not support gain-of-function research or potential pandemic pathogen enhancement at WIV are untruthful.

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More from @R_H_Ebright

Oct 17
"[H]umanity will…need new governance mechanisms…to prevent the deliberate use of biological pathogens and minimize their unintentional release…They will also need to create more robust mechanisms to reduce the risks of catastrophic accidents."

carnegieendowment.org/research/2024/…
"Two immediate priorities stand out. The first is strengthening the Biological Weapons Convention...The second priority is managing the biosafety and biosecurity risks of the democratization of biotechnology."
"Spectacular advances in gene editing and synthetic biology…risk opening the door for state governments and malicious nonstate actors to create or modify deadly, naturally occurring viruses"
Read 7 tweets
Oct 16
GARDP/WHO report:

[T]he clinical pipeline for new antibacterials remains inadequate for current and future needs

[R]eturns on investment for new ‘reserve’ antibiotics do not cover research, development, registration, manufacturing, and distribution cost

cdn.who.int/media/docs/def…Image
"Antimicrobial resistance remains one of the top 10 global health threats, linked to 4.95 million deaths in 2019—surpassing those from HIV or malaria. Recent global estimates suggest that resistant bacterial infections will cause 39 million deaths by 2050." Image
Image
"It also threatens the global economy…Without strengthened action, treating resistant bacterial infections alone would exert a global economic burden of USD 412B in healthcare costs and USD 443 B in lost productivity each year up to 2035"
Read 13 tweets
Oct 2
"The WHO has acknowledged 'there is no viable market for novel antibiotics,' adding that 'the return on investment for new 'reserve' antibiotics does not cover the costs of development, manufacturing, and distribution.'"
Image
"Developing a new antibiotic typically takes 10 to 15 years...Even if a product makes it to market, it is rarely profitable as these drugs are meant to be reserved as a last resort."
"The market for new antimicrobials is small and far from profitable. For most drugmakers, the risk of losses is offset by the prospect of much larger profit, but antibiotics are a notable exception in this respect."
Read 4 tweets
Sep 29
"Boris Johnson: "The awful thing about the whole Covid catastrophe is that it appears to have been entirely man-made in all its aspects…It now looks overwhelmingly likely that the mutation was the result of [a] botched experiment in a Chinese lab."

inews.co.uk/opinion/boris-…
Image
"The…case…has grown steadily stronger with each crumb of evidence. There was always valid suspicion over a pandemic erupting in…city that is home to the world’s foremost research lab for Sars…viruses, especially when it was found to have known concerns over safety practices."
"This lab collected thousands of bat viruses from southern China…, but hid its database. It carried out high-risk 'gain-of-function' research to boost infectivity of coronaviruses in low-level security environments, derided as 'wild west' even by its funders in Washington."
Read 7 tweets
Sep 25
"The Wuhan Institute of Virology’s chief American collaborator leveraged connections in Anthony Fauci’s inner circle to survive federal scrutiny and keep millions in public funding flowing without turning over key data, new records show."

usrtk.org/covid-19-origi…
"Hundreds of documents—emails obtained under FOIA lawsuits or congressional subpoena, as well as congressional interview transcripts—show Fauci’s institute protected EcoHealth Alliance, which collaborated on novel coronavirus discovery and engineering projects with the Wuhan lab"
"[O]fficials at the NIH’s central headquarters or “Building One”…had suspended EcoHealth’s…grant and sought lab notebooks and unpublished genomic data as a condition of getting its funding back. This information could have shed light on the coronavirus research in Wuhan"
Read 28 tweets
Sep 19
Letter to Cell: "Crits-Christoph et al. 2024 has unsound premises, has unsound conclusions, and may be a product of scientific misconduct. We urge Cell to issue an Expression of Editorial Concern for this paper and to initiate…investigation of this paper for possible retraction" Image
Link for full text of letter to Cell:
biosafetynow.substack.com/p/crits-christ…
Read 4 tweets

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