"NEWLY RELEASED documents provide details of US-funded research on..coronaviruses at the Wuhan Institute of Virology..The Intercept has obtained more than 900 pages of documents detailing..work of..EcoHealth Alliance..at the Chinese lab.."

"The trove of documents includes two previously unpublished grant proposals that were funded by the NIAID, as well as project updates relating to the EcoHealth Alliance’s research, which has been scrutinized amid increased interest in the origins of the pandemic."
The materials show that the 2014 and 2019 NIH grants to EcoHealth with subcontracts to WIV funded gain-of-function research as defined in federal policies in effect in 2014-2017 and potential pandemic pathogen enhancement as defined in federal policies in effect in 2017-present.
(This had been evident previously from published research papers that credited the 2014 grant and from the publicly available summary of the 2019 grant. But this now can be stated definitively from progress reports of the 2014 grant and the full proposal of the 2017 grant.)
The materials confirm the grants supported the construction--in Wuhan--of novel chimeric SARS-related coronaviruses that combined a spike gene from one coronavirus with genetic information from another coronavirus, and confirmed the resulting viruses could infect human cells.
The materials reveal that the resulting novel, laboratory-generated SARS-related coronaviruses also could infect mice engineered to display human receptors on cells ("humanized mice").
The materials further reveal for the first time that one of the resulting novel, laboratory-generated SARS-related coronaviruses--one not been previously disclosed publicly--was more pathogenic to humanized mice than the starting virus from which it was constructed...
...and thus not only was reasonably anticipated to exhibit enhanced pathogenicity, but, indeed, was *demonstrated* to exhibit enhanced pathogenicity.
The materials further reveal that the the grants also supported the construction--in Wuhan--of novel chimeric MERS-related coronaviruses that combined spike genes from one MERS-related coronavirus with genetic information from another MERS-related coronavirus.
The documents make it clear that assertions by the NIH Director, Francis Collins, and the NIAID Director, Anthony Fauci, that the NIH did not support gain-of-function research or potential pandemic pathogen enhancement at WIV are untruthful.

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More from @R_H_Ebright

Oct 3
"Lawmakers are on the brink of missing a critical window to fix America’s broken antibiotic market—and to prepare for the growing crisis of superbugs that federal officials say is a national security threat and experts warn is already a silent pandemic."

"Nearly 50,000 people die each year in the U.S. from drug-resistant and antibiotic-associated infections, according to the CDC."
"[T]he handful of drugmakers developing new antibiotics..struggle..stay afloat. [C]ompanies that..ushered..drugs through..development..have gone bankrupt.., buckling under the financial pressure of selling a product that..needs to be used sparingly to preserve its power"
Read 10 tweets
Oct 2
"New..antibiotics are urgently needed to..tackle the global health threat of antimicrobial resistance.., as infections become..resistant to current treatments."

"New research..support[s],,,implementation of a Transferable Exclusivity Extension (TEE)"

"The figures support..implementation of a TEE–showing it to be the most credible and workable solution for driving antibiotic research in Europe. The system could bring 2 new antibiotics a year.., preventing some of the 400,000 deaths associated with AMR every year in the EU."
"TEE works by providing the developer of an eligible, novel antibiotic a voucher that can be used to extend the exclusivity of one of its own medicines for a period of time, or sold to another company, thereby paying for successful antibiotic research."
Read 4 tweets
Sep 30
“Giving taxpayer money to EcoHealth to study pandemic prevention is like paying a suspected arsonist to conduct fire safety inspections. NIH got it right when it canceled..funding for..experiments EcoHealth Alliance was conducting with..Wuhan"

"In addition to violating multiple federal laws, EcoHealth has still not turned over documents about these dangerous studies that NIH has requested on multiple occasions that could offer vital clues to the origins of the COVID-19 pandemic."
"I have introduced legislation to guarantee EcoHealth doesn’t receive another penny from any federal agency "
Read 4 tweets
Sep 28
House letter, 09/28/22:

"Safety concerns with virus-hunting raised in recent reports and articles and from our oversight into the origins of the COVID-19 pandemic suggest the need for enhanced training and oversight of biosafety practices in the field."

"Even if it is not connected to the origins of the pandemic, the risks are apparent and biosafety practices need to be strengthened as our oversight examines the risks and benefits of virus-hunting research to prevent pandemics."
"Biosafety concerns over virus hunting have been elevated by..scrutiny over..origins of..COVID-19.., especially..suspicions about..the EcoHealth – WIV partnership. Both of these entities have a history of not always following safety precautions for virus hunting or in the lab"
Read 5 tweets
Sep 28
"Nuclear technology is burdened with..ethical issues that led..UN to create the International Atomic Energy Agency..Covid19 pandemic should trigger an analogous response addressing..risks inherent to research on enhanced pathogens with pandemic potential"

"We are working scientists and bioethicists who are extremely concerned about the type of virological research activities known [as]..'Gain of Function Research of Concern'..and 'enhanced Potential Pandemic Pathogens' (ePPP) research."
"ePPP research remains under the control of direct stakeholders, who have an unavoidable conflict of interest. The public must demand a more rational approach."
Read 5 tweets
Sep 26
"The market for new antibiotics is broken, and that’s a problem because our current ones are failing."

"When antibiotics fail, people pay the price with their lives."

Congress needs to fix the antibiotic market thehill.com/opinion/health…
"We are at a tipping point now where antibiotic resistant infections are so common, the World Health Organization declared antibiotic resistance as one of the top ten global health threats."
"Millions of Americans already suffer from antibiotic resistant infections each year, and tens of thousands die annually because a disincentive stands in front of new antibiotic development."
Read 6 tweets

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