You Eat My Brain

This autopsy study showed a frequency of 9/44 (20.4%) macroscopic and 14/44 (31.8%) microscopic hemorrhages or thrombotic phenomena in the nervous system. Tang et al. suggest that hemostatic abnormalities, such as high D-dimer and Fibrin Degradation Product>
levels longer prothrombin time, and activated partial thromboplastin time (aPTT), affect COVID patients and are more frequent in severe disease when compared to survivors on admission. Similarly, our patients with hemorrhages presented a trend for higher aPTT and D-dimer. In our>
In our autopsies we described macroscopic and microscopic hemorrhages, and we focused only on these...
A pronounced CNS involvement with pan-encephalitis, meningitis, and brainstem neuronal cell damage in 6 autopsied pts. was described by Weyhern in pts. from Germany. Petechial>
bleeding was found in 4 patients (8.8%), and only 2 of them were younger than 60 yrs. In our pts., ERYTHROCYTES in PERIVASCULAR SPACE and/or MICROHEMORRHAGE were found in 21/44 (47.7%). In a small series of COVID pts. younger than 50 yrs, the vascular territory most affected was>
the LEFT MIDDLE CEREBRAL ARTERY (3/5 pts), and 3 pts presented elevated levels of D-dimer (up to 500 ng per ml) our pts., we FREQUENTLY FOUND MICROSCOPIC PETECHIAL HEMORRHAGES, SIMILAR TO what is described in CEREBRAL MALARIA...The elevation of D-dimer levels, also observed
in other case series, is directly related to the severity of the disease and can be used as one of the indicators of COVID progression. High levels of D-dimer suggest hypercoagulability...
SARSCoV2 Infection of the CNS in a 14-Month Old Child…
SARSCoV2 staining was observed along the APICAL REGION of the CHOROID PLEXUS EPITHELIUM and in EPENDYMAL cells of the LATERAL VENTRICLE, but was restricted to ChP capillaries and vessels>
in some regions...our findings of ChP infection and viral neurotropism suggest that SC2 may invade the central nervous system by BLOOD-CEREBROSPINAL FLUID BARRIER DISRUPTION.
The small number of studies so far conducted to investigate histopathological characteristics of COVID neuro‐involvement did not seem to have highlighted any specific damage of brain tissue directly caused by the virus itself.
The described neuropathological findings seem to be MORE LIKELY because of SYSTEMIC INFLAMMATION and coagulopathy caused by SC2 infection, which may lead to a reactive response of CNS components and to the genesis of infarcts, hemorrhages, and microthrombi...

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