More evidence to support the hypothesis that full vaccination following NI is actually HARMFUL and reduces immune protection. jci.org/articles/view/…
"the second injection appears to be ineffective, and it is rather associated to a contraction of both Spike-specific circulating B and T cells in the COVID-19–recovered group."
"We also cannot exclude that the second injection might even be detrimental in this context, possibly leading to a functional exhaustion of Spike-specific lymphocytes (20)." @akheriaty
"Indeed, we observed a decrease in the frequency of both B and T cells at day 28 (1 week after second dose), but also a decline in the titer of neutralizing Ab at day 50. This is an intriguing hypothesis, but further studies are needed to fully prove it."
T cell exhaustion explained, "In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called 'exhaustion'." pubmed.ncbi.nlm.nih.gov/26205583/
"Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with inefficient control of persisting infections and tumours."
Paper suggests that some people some of the time might under some circumstances gain some short-term benefit from one dose of vax post-recovery (yes--that's a lot of "somes").
This is consistent with the similar findings of Camara that found T cell depletion after 2 doses post-NI. @mahesh_shenai biorxiv.org/content/10.110…
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