Validated, replicated & properly powered high quality clinical trials are lacking
meaning,
actual evidence for Karela juice/extracts is not present in medical literature
most of the videos/recommendations r based on flimsy foundational level evidence and appeal to tradition +
Trials of Karela juice or extracts conducted on humans are only a handful and most are underpowered to actually identify efficacy and safety of such formulations ncbi.nlm.nih.gov/pmc/articles/P…
Good data in animal models show bitter gourd extracts cause series of adverse events +
- α-momorcharin (a plant chemical in karela) related inflammatory reaction
- juice formulation leading to to acute poisoning symptoms such as acute convulsions, nervous disorders, jumping, and shortness of breath
- causes abortion and teratogenic side effects, damaging fetus +
- toxicity to fetus + cardiotoxicity of karela extracts in zebrafish embryos
- decrease in estrogen, progesterone hormone levels leading to dose-dependent antifertility effect
- and sperm damaging and reduction of sperm count resulting from antispermatogenic effect in male rats +
Further, studies in animals have also shown that concentrated form of bitter gourd can lead to liver damage
A review of safety reported adverse effects including hypoglycemic coma and convulsions in children, reduced fertility in mice, a favism-like syndrome, increases in gamma-glutamyltransferase and alkaline phosphatase levels in animals, and headaches
We recently published our independent analysis of Homeopathic practitioner commonly prescribed and popular over-the-counter 134 Homeopathy products marketed and sold as "medicine."
The Placebo Project: An observational study and comprehensive analysis of 134 commonly prescribed homeopathic remedies in India uncovers potential for hepatotoxicity: journals.lww.com/md-journal/ful…
Here is our plain language and visual abstract summary of what these Homeopathy products are and what we found in them.
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