The Sign

...evidence that a circulating 3-microRNA SIGNATURE correlates with cognitive function, is linked to COGNITIVE DECLINE, that the 3 microRNAs regulate processes important for neuronal plasticity in the adult brain and that the signature serves as a target for RNA>
therapeutics. These data provide unprecedented evidence for the view that the blood microRNAome could be suitable as molecular biomarker for neuropsychiatric and neurodegenerative diseases>
Alzheimer’s disease (AD) is usually diagnosed at an advanced stage of molecular pathology... This study aimed to identify a minimally invasive BIOMARKER that can help to identify individuals at RISK for COGNITIVE DECLINE BEFORE clinical MANIFESTATION>
-Circulating microRNAs are LINKED to COGNITIVE FUNCTION in young and healthy humans.
-A circulating 3-microRNA SIGNATURE IS IDENTIFIED using a longitudinal mouse model of age-associated memory decline.
-The expression of the 3-microRNA signature is increased in patients with>
cognitive impairment (MCI) and is associated with future conversion from MCI to AD.
-Targeting all 3- microRNAs using anti-miRs ameliorates cognitive decline in AD mice...Further analyses suggested that the top 5 significant biological processes affected by the predicted>
targets of these 3 microRNAs are linked to NEURONAL PLASTICITY (e.g., synapse organization, vesicle-mediated transport in synapse), GTPase-mediated signal transduction, protein localization to cell periphery, and the response to transforming growth factor beta>
This finding suggests that the 3 microRNAs can CONTROL KEY PROCESSES that are LINKED to COGNITIVE function that are deregulated during age-associated cognitive decline, including SYNAPTIC FUNCTION and INFLAMMATORY processes..We observed several significant processes related to>
cellular stress and inflammation that were increased in response to treatment with miR-148a-3p and especially miR-146a-5p mimics. That increased level of miR-146a-5p can CONTRIBUTE to INFLAMMATION-RELATED processes was further confirmed by qPCR showing the UPREGULATION of the>
PRO-INFLAMMATORY CYTOKINES IL-1beta, IL-6, and TNF-alpha, while the anti-inflammatory cytokine IL-10 was decreased...We also compared our transcriptomic findings to gene expression datasets from CK-p25 mice, a mouse model for AD-like neurodegeneration...as well as gene>
expression and proteome data from human AD patients...the GENES and PROTEINS downregulated in AD patients STRONGLY OVERLAPPED with the DOWNREGULATED GENES observed in response to miR-148a-3p and especially miR-181a-5p..,these data further confirm the hypothesis that increased>
levels of the 3 microRNAs reflect key processes important to neuronal and synaptic integrity that are known to be deregulated in cognitive diseases.
embopress.org/doi/full/10.15…

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More from @janieyaya

12 Oct
Hahaha @IMDb @IMDbTV @imdbpro
you are as IGNORANT as you are CORRUPT.
Fauci killed thousands during the AIDS crisis with AZT and by stalling the use of Bactrim. He's repeating history with toxic Remdesivir and #VentsKill, neither of which treat Covid. #CovidIsVascular. #IMDb
Read 6 tweets
12 Oct
🌬️ Windy 🌬️

From our review of the literature, it is clear that enhancing the ventilation, whether through INCREASING the VENTILATION RATE or MODIFYING the AIRFLOW pattern is an effective way to REDUCE AIRBORNE VIRAL INFECTION risk.>
...enhancing ventilation across an entire building might not be feasible due to economic or HVAC system limitations...suggests PAYING CLOSE ATTENTION to SPACES where the OCCUPANTS are ENGAGED in HIGH EXPIRATORY ACTIVITIES such as singing, speaking loudly, or heavy exercising.>
If mechanical ventilation is not available or is insufficient, NATURAL VENTILATION through opening windows and doors should be utilized.
Harrichandra et al studied 12 nail salons in New York City and determined that the RISK WAS LOWEST in the nail salon with the HIGHEST>
Read 7 tweets
11 Oct
💊 I Want a New Drug 💊

The team investigated more than 400 COVID patients from hospitals across the US who take ASPIRIN unrelated to their COVID disease, and found that the treatment REDUCED THE RISK of several parameters BY ALMOST HALF: reaching mechanical>
ventilation by 44% ICU admissions by 43%, and overall in-hospital mortality by 47%.
“As we learned about the connection between blood clots and COVID, we knew that ASPIRIN – used to prevent stroke and heart attack – could be IMPORTANT for COVID patients,” said Dr. Jonathan Chow>
of the study. "Our research found an association between low-dose aspirin and DECREASED SEVERITY of COVID and DEATH.” Israeli researchers reached similar results in a preliminary trial at the Barzilai Medical Center in March. In addition to its effect on blood clots, they found>
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9 Oct
👄 Bad Mouth 👄

Increased COVID severity may be linked to poor oral health status, especially in patients with cardiovascular diseases...study assessed oral health status, severity of COVID symptoms, C-reactive protein (CRP) levels and duration of recovery.>
“Oral tissues could act as a reservoir for SARSCoV2, developing a HIGH VIRAL LOAD IN THE ORAL CAVITY...The study included 86 Egyptian heart disease patients with a confirmed COVID-19 PCR test... researchers from Cairo University assessed oral health and COVID severity.>
An oral health score was used to determine the effect of oral health on COVID. Data on CRP levels and COVID PCR tests were collected via the questionnaire and confirmed via medical records. CRP levels are used to determine when there is inflammation in the body...the correlation>
Read 5 tweets
7 Oct
🧠 Brain Damage 🧠

....a new strategy to probe the effects of SC2 on human brains in a linked alveolus-BBB organ chip platform.
The new multi-organ platform allows to recapitulate
the essential features of human alveolar-capillary
barrier and blood-brain barrier in a>
microgluidic condition by co-culturing the organ-specific cells. The results reveal direct SC2 exposure has no obvious effects on BBB chip alone. While, infusion of endothelial medium from infected alveolus chips can cause BBB DYSFUNCTION and NEUROINFLAMMATION on the linked chip>
platform, including BRAIN ENDOTHELIUM DISRUPTION, GLIAL CELL ACTIVATION and inflammatory CYTOKINES release...new findings suggest that SC2 could induce neuropathological alterations, which might not result from direct viral infection through hematogenous route>
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6 Oct
🧪Poison or Prescription?💊

Are health authorities are giving a drug helps the
disease to kill? Remdesivir suppresses patients'
cellular respiration in cardiomyocytes.

Is Remdesivir helping
COVID DESTROY MITOCHONDRIA? >
"Remdesivir induced MITOCHONDRIAL FRAGMENTATION, reduced redox potential and SUPPRESSED MITOCHONDRIAL RESPIRATION...
Non-mitochondrial damage such as ELECTROPHYSIOLOGICAL ALTERATIONS and SARCOMERE DISARRAY were also observed. Importantly, some of these CHANGES PERSISTED after>
the cessation of treatment, culminating in INCREASED CELL DEATH...inhibition of DRP1, a regulator of mitochondrial fission, ameliorated the cardiotoxic effects...showing that REMDESIVIR-INDUCED CARDIOTOXICITY was preventable and excessive mitochondrial fission might contribute.."
Read 8 tweets

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