1) LONG COVID AS A DISEASE OF (ACUTE?) IRON OVERLOAD
I will explore various aspects of Long COVID in the context of iron overload disease. We will now discuss iron overload and the weakness/exercise intolerance/weight loss/cachexia occurring in Long COVID.
Previously healthy mice
2) were injected with iron. The results are remarkably similar to what happens in Long COVID. If the body has too much iron, it upregulates Ferritin. Therefore, high ferritin in the ABSENCE of high serum iron may indicate that the muscles and organs are already overloaded.
Please
3) reference the graphic showing the ferritin levels of the mice injected with iron vs control.
How does this present clinically? Fatigue, exercise intolerance and muscle atrophy, which presents as weight loss. Please reference the graphic showing weight loss of the iron injected
4) mice vs control.
A common problem for people with iron overload disorders is fatigue, with studies showing a decrease in maximal exercise capacity in symptomatic but not in asymptomatic patients. Weakness is a common presenting symptom in iron overload disorders. Iron overload
5) has also been linked to, the age-associated decline in muscle mass and quality.
Following iron treatment, the iron group weighed 21% less than the control group (P < 0.001).
Interestingly, a recent study by McKenna and colleagues demonstrated that muscle fatigue can be
6) attenuated by the antioxidant N-acetylcysteine!
physoc.onlinelibrary.wiley.com/doi/full/10.11…

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More from @Parsifaler

14 Oct
1) AN UNEXPECTED, YET FASCINATING TURN
THE SPIKE PROTEIN, THROUGH HEPCIDIN MIMICRY, INDUCES IRON OVERLOAD AND MITOCHONDRIAL PROTON/ELECTRON LEAK: THE OBSERVED “RADIATION POISONING” IS THIS PROTON/ELECTRON LEAK: CACHEXIA, AGING, ENDOTHELIAL AND CARDIOVASCULAR COVID PATHOLOGIES ImageImage
2) EXPLAINED
Hepcidin: The Dark Crystal
Hepcidin, a small polypeptide synthesized and secreted by the liver, is considered a master regulator of body iron homeostasis. The physiological function of hepcidin is to decrease circulating iron levels through down-regulation of FPN1 in Image
3) macrophages. The action of hepcidin is tissue-specific: in enterocytes, hepcidin does not change FPN1 levels but decreases DMT1 expression. Hepcidin-induced FPN1 degradation is transient reaching a maximal effect at 2–6 h, with FPN1 levels returning to control values at 24. Image
Read 23 tweets
13 Oct
1) THE SPIKE PROTEIN: A PHARMACOLOGICAL “THERAPEUTIC” INTENDED TO INDUCE FATAL SYSTEMIC IRON DEPOSITION: DYSMETABOLIC HYPERFERRTINEMIA
First, please think about all we have read concerning COVID and its sequelae. Now please read this: Iron overload, irrespective of the underlying ImageImage
2) etiology, has varying manifestations, depending on the organs affected by the excessive iron deposit. It may present as fatigue, skin color changes, abdominal pain, joint pain, irregular menstruation, infertility, impotence, irregular heart rhythm, heart failure, new-onset Image
3) diabetes or difficulty controlling established diabetes and elevation in liver enzymes.
And what of Hypoxia? Pathological? Certainly. Also, a possible adverse effect of a drug intended to induce fatal systemic iron deposition. While we have been scratching our heads trying to
Read 17 tweets
13 Oct
1) COVID AND TRANSFERRIN: UNITING IRON OVERLOAD, COAGULOPATHY, AGING, SENESCENCE, AND SHORTENED TELOMERES
A paper from May 2021 out of Wuhan noted that a previous study in Austria found that ferritin and transferrin were both associated with the risk for ICU admission in COVID-19 Image
2) patients, and no significant relations were found in iron and other indices. This study indicated the relation between iron metabolism and the undesirable outcome of COVID-19, whereas the association with specific comorbidities warrants further investigation. In our study, we
3) found high serum iron level was associated with disease severity in COVID-19 patients.
Transferrin is a protein that binds iron and transports it throughout the body. It is the main iron carrier in the blood. Transferrin levels normally increase with iron deficiency. When iron
Read 12 tweets
12 Oct
What if the spike protein, through its mimcry of Hepcidin and affinity for ACE2 receptors, caused such a massive efflux of iron into the bloodstream, that it mimicked an "iron injection?"

There is such a drug! Iron Dextran Injection.

What can happen?

Iron dextran injection may
cause severe or life-threatening reactions while you receive the medication. You will receive this medication in a medical facility and your doctor will watch you carefully during each dose of iron dextran injection. Tell your doctor if you experience any of the following
symptoms during or after your injection: shortness of breath; difficulty swallowing or breathing; wheezing; hoarseness; swelling of the face, throat, tongue, lips, or eyes; hives; itching; rash; fainting; lightheadedness; dizziness; bluish discoloration of the skin, lips,
Read 5 tweets
11 Oct
1) DELAYED SELF-POISONING (OR A QUICK DEATH VIA MACROPHAGE ACTIVATION SYNDROME)
THE SPIKE PROTEIN OF SARS-CoV-2 IS AN ENGINEERED BIOWEAPON DESIGNED TO CREATE MASSIVE, ALMOST CERTAINLY LETHAL (DELAYED, AS IS THE CASE WITH EXTREME IRON OVERLOAD) IRON EFFLUX FROM MACROPHAGES AND
2) RBCs. THE OBSERVED HYPOXIA IS PART OF THIS “PLAN.” THE BODY RELEASES YET MORE IRON UNDER HYPOXIC CONDITIONS: THE PARACRINE PARALLEL TO RADIATION POISONING.
A fascinating article appeared on ideas.ted.com in December of 2015. The chemist Rebecca Abergel realized the
3) way to cure people of radiation poisoning was to remove it from the body, as it spreads in a PARACRINE fashion.
At high doses, radiation blasts through tissues, ruptures DNA strands and alters the rhythms of cell division. Disrupted cells cause nausea, diarrhea and fever,
Read 11 tweets
9 Oct
1) COVID-19 IS AN IRON OVERLOAD-INDUCED STEM CELL DISEASE. IT IS FAR MORE DANGEROUS THAN ANYONE HAS PREVIOUSLY REALIZED. IF INTERFERON GAMMA CALLS ON hPSCs FOR “REINFORCEMENTS,” THE “TROOPS” SENT ARE DEFECTIVE. THIS IS WHY PEOPLE DIE. THJS IS WHY LONG COVID'S
2) CANCER/NEURODEGENERATION, ETC., DOES NOT MANIFEST FOR WEEKS/MONTHS POST SPIKE PROTEIN EXPOSURE. IT IS ONLY AFTER THE HEALTHY CELLS DIE AND ARE REPLACED WITH DEFECTIVE CELLS.
Interferon Gamma has been the Dr. Jekyll and Mr. Hyde of the COVID-19 pandemic. In moderate disease,
3) it has been found to be extremely therapeutic. In severe disease, it can be a marker for a fatal outcome. This is because it is the canary in the coal mine of COVID-19.
A paper from the Department of Pharmacy at the Second Affiliated Hospital - Harbin Medical University in
Read 11 tweets

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