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Alexandros Marinos 🏴‍☠️ Profile picture
@alexandrosM
Oct 20, 2021 • 15 tweets • 4 min read • Read on X
Why don't we have a delta-targeting vaccine available right now? I thought the promise of mrna tech was that it would be quick to adapt to variants?

I'll tell you the hypotheses I know of, you tell me yours.
Hypothesis 1. Regulation makes it difficult to push through a new variant vaccine.
Hypothesis 2. The iPhone effect: if people know a new vaccine is coming, they might hold off taking the existing one
Hypothesis 3. Original Antigenic Sin makes variant vaccines pointless.
Hypothesis 4. Delta evades vaccines mostly by higher viral load. There's not much we can do by updating the vaccine in terms of better binding to the spike, etc.
Hypothesis 5. Vaccination against original SARS-COV-2 triggered the dominance of delta variant. If we vaccinate most people against Delta, we may trigger the next strain to sweep, which may be even more aggressive, while only getting temporary protection. Image
Hypothesis 6. Supply chain woes: we'd need to throw out our stockpiles and restock with new variant vaccines.
Hypothesis 7. It's coming soon you Muppet!
Hypothesis 8. Spicy!
Hypothesis 9. Bad optics, admitting dropping efficacy.
Hypothesis 10. within-delta evolution (e.g. AY.23 or AY.4.2) means we would still be behind by the time we get the new vaccine out.
Hypothesis 11. It's over. It's going endemic, mix of natural and vaccine immunity is pushing this thing under, that's good enough, we're also getting early treatment options, and we can focus on producing enough doses for the world.
Hypothesis 12: (blackpill) the original vaccines work for the actually intended use case, which may not be exactly identical to the one being promoted.
Hypothesis 13. Diminishing returns (scroll up for the full thread by Scott, it's worth it)
Hypothesis 14. Everything is awesome. I am a conspiracy theorist. (hypothesist, but who's counting).

• • •

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More from @alexandrosM

Alexandros Marinos 🏴‍☠️ Profile picture
Dec 3
Did you now that the PRINCIPLE trial out of the UK found that IVM was superior to the usual care in practically every subgroup it tested, but it sat on the results for ~600 days? When it finally published, it buried these results in page 346 of the appendix. Image
The main body of the paper they published is even more bizarre --

1. They claim that "clinically meaningful" meant 1.5 days improvement in median time to recovery.
2. They admit that ivermectin showed >2 days to recovery.
3. Their main conclusion is that ivermectin is unlikely to provide clinically meaningful improvement in recovery.

sciencedirect.com/science/articl…Image
Image
Image
The secret sauce in their conclusion is that their target metric of HR 1.2 is based on 9 days of recovery needed (after randomization). Even though they had ran many hundreds of patients by the time they started the ivm arm they knew the days needed for recovery were >14.
Read 21 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Apr 19
Let's do a thread doing a close reading of Douglas Murray's article in the NY Post, in which he writes about his encounter with Dave Smith on Joe Rogan's podcast.

If you care about facts and truth and stuff, I promise this will be highly illuminating. 🧵 Image
Early in the article he writes this:

"Having not spoken to Joe since the wars in Ukraine and Israel started, I had become increasingly irked that the guests he has had on have been almost entirely anti-Ukraine and anti-Israel."

As many have demonstrated, this is false.
Since late 2023, at the very least these guests with strong pro-israel views have appeared at least once on the podcast.

Gad Saad
Mike Baker
Peter Zeihan
Douglas Murray
Coleman Hughes
Konstantin Kisin (3 times)
Read 45 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Mar 26
A thread where I post a bunch of receipts of interesting information on the Jefferey Goldberg Signal leak of Yemen war plans.

1. It appears Signal was not only allowed but recommended for government officials?
2. This might have been the JG that Waltz was trying to add to the groupchat?

3. Tulsi Gabbard (and pretty much everyone else except for Goldberg) claims no classified information was shared in the chat.
Read 17 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Feb 19
Is Zelensky operating with out a mandate?

I dug into the constitution of Ukraine to figure this out for myself.

Article 103, paragraph 5, clearly says that the presidential elections should have been held in 2024.

(thread continues below) Image
Article 83 also says that if the president declares martial law, then the **parliamentary** elections can be delayed until martial law is lifted.

Notice that it doesn't say that the presidential elections can be postponed.

English translation here: natlex.ilo.org/dyn/natlex2/na…Image
So, the Ukranian constitution gives the president the power to declare martial law, and explicitly says that parliamentary elections can be delayed until after martial law is lifted. For presidential elections it says they must happen every 5 years with no martial law exception.
Read 8 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Jan 26
Whitney Webb's failure to admit error, (and how to survive the 2025+ infowars without getting blackpilled)

I had a run-in with Whitney Webb this week. This THREAD will try to walk you through the story in excruciating detail.

This will take a while, but I think it's worth it.
It all started when @BretWeinstein thanked @POTUS for withdrawing from the WHO. Bret had fought long and hard against the WHO pandemic treaty that was being pushed, so whoever had followed him knows how important this is.
@BretWeinstein @POTUS Whitney Webb felt the need to point out that "Trump also left the WHO in mid-2020 and then just redirected what was once WHO funding to the Gates-funded GAVI vaccine alliance."

Read 44 tweets
Alexandros Marinos 🏴‍☠️ Profile picture
Jan 21
Your favorite blackpill dealer, Whitney Webb, here with more trash data and vague insinuations.

In this episode, she claims Trump "redirected" WHO funding to GAVI. In reality, she is asserting that unrelated funding from USAID to GAVI was made because of the withdrawal from WHO in 2020.

The USAID funding to GAVI was part of a long-term funding stream that USAID had been providing to GAVI since 2001.

more details here:
usaid.gov/sites/default/…Image
Some people are saying that maybe the 1.4B in 2016-2020 was concentrated in 2020. Not true. A billion was pledged for the period of 2015-2018. Then 1.16 billion was pledged for the period between 2020-2023. Taking inflation into account, that is effectively the same amount, for the same duration of time.

gavi.org/investing-gavi…Image


And more receipts for the years 2018 and 2019 csis.org/analysis/susta…Image
Read 6 tweets

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