SHIFT in CDC: Feel like was likely the biggest news of the week & the message may have been missed. With such a transmissible virus, shift away from herd immunity goal is prudent. Can no longer count cases as goal of US epidemic (e.g. get <10K etc.). ktla.com/news/nationwor…
If we track cases as our main metric after vaccination, you will see this yo-yo effect. In late September, CA had lowest cases (yes people gather inside as it gets colder), now FL has lowest cases but tracking hospitalizations is the key after vax abc7.com/california-cov…
And - during delta- a lot of natural immunity occurred in Florida, tragically in many cases but also a lot of natural immunity in younger healthier individuals too which brings up the IgA in the nose & brings down cases; this is chasing one's tail
If track hospitalizations are main metric, we will know who to boost (immunocompromised, J&J, older individuals >65) from data so far to protect against disease; we will see that giving young IgA boost from vax will decrease again; we can shift thinking sfchronicle.com/opinion/openfo…
This shift in thinking is imperative to make now or the case metric states like CA using now will not allow reasonable public health policy decisions which are to do whatever it takes to prevent disease - that is what public health's mission is.
During delta surge in the US, cases became uncoupled from hospitalizations in areas of high vaccination like SF. Now during this surge of cases, imperative to figure out risk factors for hospitalizations with vax (>65, immunocompromise), boost aggressively sfchronicle.com/health/article…
CDC's shift that we can't reach herd immunity with such a transmissible variant is not giving up- no one is giving up; ongoing vaccinations, deciding the best way to administer boosters, antivirals coming, child vaccines, all get us to control (not herd immunity but control)
Of note, details of football outbreak Cal emerging in terms of symptomatic/ asymptomatic infections (check local news sources for details) so points raised in this piece are not about football but shift in thinking reflected by the CDC this past week on control not herd immunity
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SCHOOL CLOSURES: Wow, think we should invest in emotional support for children instead of closing schools again after prolonged schools closures last year (that led to mental/emotional difficulty).
I gave talk in Pediatric Grand Rounds this am at UCSF which made me look more deeply at the history of school closures for infectious diseases in US. School closures were ALWAYS last resort & only happened for raging infections (esp those worse for kids than adults like measles)
In influenza pandemic of 1918 (encourage you to read this article), schools were not closed in NYC (& Chicago/ New Haven) because progressive cities (we really changed!) & out of 1 million children, 750K were not from affluent families; schools place for food, safety, learning
Protective immunity after recovery from SARS-CoV-2 infection - an important review in Lancet ID about protection from repeat infection after prior infection vs vaccination. Immunologic review AND review of re-infection studies thelancet.com/journals/lanin…
#1. Developing illness is what all doctors are sworn to prevent so there is rarely advocacy for natural infection but this is what happens if natural infection occurs. Strongest immunologic evidence for enduring immunity, T cells from Science study here: science.org/doi/10.1126/sc…
And 2nd amazing paper showing that your B cells will adapt antibodies if they see a variant in the future to the variant in front of them is here (we have discussed this and the above paper in T & B cell threads if you search them) science.org/doi/epdf/10.11…
We need to start thinking differently about COVID outbreaks- this is not really about this particular outbreak (we don't know all the details)- this is about thinking differently after vaccines: sfchronicle.com/opinion/openfo…
INDIA: True that cases rising in US during the winter (at least colder states) which happens with any respiratory virus (as people gather inside during colder months). But not rising in India (and COVID hospitalizations remaining low). This being taken to mean that natural
immunity more powerful than vaccination because India had such a terrible 2nd wave but would point to 2 things: 1) Natural immunity came at terrible price of suffering & death; most of our COVID deaths in US since delta among unvaccinated; 2) This study jamanetwork.com/journals/jama/…
showed that vaccinated individuals with prior infection 6 months or more before (HYBRID IMMUNITY) had statistically significantly lower risk for breakthrough infection than those vaccinated less than 6 months before dose 1 (adjusted hazard ratio, 0.62). Hybrid immunity powerful
Democrats Desperately Need Schools to Get Back to Normal- important article "Because America’s response to Covid was so politically polarized, school shutdowns longest in blue states..only 6 states had fewer in-person days last year" than VA (CA was 50/50) nytimes.com/2021/11/08/opi…
May be difficult from parents in other states to understand but this is what it feels like to be a parent in a blue state right now- November 2021. @JVergales and I and so many others have written about how quarantine in 2021 is the new "school closure" from 2020
important thing about quarantine as a historical concept in infectious diseases is that the benefits of that practice were ALWAYS weighed against its risks of isolation, exclusion, lost opportunities, and educational loss if enacted @JVergales & I write washingtonpost.com/outlook/2021/1…
NYC Mayor (Democrat) said today "off ramp" for masking in schools (Jan now that 5-11 vaccine here). Whatever metric you choose (MA doing 80% vax in community + hospitalization rate), looks like @NYT piece below (local NYC paper) opened door to discussion forbes.com/sites/marisade…
Reason to discuss is that children have had more restrictions in our country (more in blue states) than adults though less at risk. Our group's research on masks show masks protect wearer; anyone can still mask after mandate lifted to protect themselves cell.com/med/pdf/S2666-…
Finally although @sfchronicle@erinallday wrote piece on off-ramps for masking children in schools today, @NYT ("liberal" paper, opposite coast) wrote powerful piece supporting school openings in 8/21; they were right, heralded last week's election nytimes.com/2021/08/21/opi…