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P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Nov 17, 2021 • 14 tweets • 5 min read • Read on X
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Men have ~5 times the rate of heart attack and heart disease in middle age, compared to women.

Hypothesis is that it's due to rheological properties of blood, and that regular blood donation can fix this. Image
Essentially, women have blood that has a higher proportion of newer RBCs, as do blood donors.

content.iospress.com/articles/clini…
Direct relation between blood viscosity and insulin resistance.

Idea is that high viscosity means blood can't properly perfuse muscle, which is where 80% of glucose goes. pubmed.ncbi.nlm.nih.gov/9535148/
Patients who had low fibrinogen, a blood clotting factor, had low risk of heart attack or sudden death even with high cholesterol. nejm.org/doi/full/10.10… Image
Curcumin lowers high fibrinogen in 15 days. sciencedirect.com/science/articl… Image
Fibrinogen, a blood clotting factor, is a powerful predictor of all-cause mortality. You really don't want to have a high level. ahajournals.org/doi/full/10.11… Image
The usual suspects are associated with high fibrinogen: age, smoking, physical inactivity, and noteworthy, high carb consumption. Image
Moderate alcohol consumption decreases fibrinogen. 12% reduction in 3 weeks in healthy volunteers.

nature.com/articles/16014…
Omega-3 fatty acids from fish oil decrease blood viscosity, and that may account for (some of) its benefits. bmj.com/content/288/64…
People in the highest quartile of blood viscosity were over 60% more likely to develop diabetes. academic.oup.com/aje/article/16…
Obese people have higher blood viscosity and fibrinogen, and weight loss decreases both. europepmc.org/article/med/82…
Cardiovascular benefits of phlebotomy are (at least in part) due to decrease in blood viscosity. Image
The role of blood hyperviscosity in vascular disease.

Have we been looking at the wrong risk markers all along?

Does hyperviscosity represent the true cause of heart disease? Image

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More from @Mangan150

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jan 7
The government just launched new guidelines to replace the old food pyramid.

Are they any good?

Let’s find out: Image
First, they’re leading with data.

1 out of 2 people have diabetes or pre-diabetes. Image
Next, 3 out of 4 people have at least one chronic condition. Image
Read 6 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Dec 29, 2025
As 2025 comes to a close, here's what you need to know about setting your 2026 health goals:

92% of adults have poor metabolic health.

And most are focused on the wrong metrics.

Here's the deal: Image
The most powerful predictor of chronic disease risk isn't your BMI, your weight, or your cholesterol.

It's your waist size. And you can measure it right now at home with nothing but a piece of string. Image
The Formula: Measure your waist at its widest point (around your belly button, not your pants size, since these are fake). That number should be no more than half your height.

Example: At 70 inches tall, your maximum reasonably healthy waist is 35 inches.Image
Read 5 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Dec 29, 2025
Here's how I never workout for more than 60 or 70 minutes per week…

And why 99% of people should do the same: Image
First things first, why should you listen to me on this topic?

I'm a 70 year old former microbiologist. For the past 15 years, I've been working with clients 1-on-1 as abody transformation coach.

So far I've helped 1600 men and women get lean, fit and strong in minimal time. Image
Before we get into it, let me be clear:

I am NOT saying that you should train for 60-70 minutes per week and then sit on your rear end the rest of the time.

As such, we need to distinguish between exercise (training) and activity.
Read 21 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Dec 27, 2025
I’m turning 71 next year, and I have 12% body fat.

If you want to lose 20, 30, 50 or 100 pounds in 2026…

What you don’t want to be doing is doubling down on willpower and discipline.

Here’s what to do instead: Image
The smart way to do self-improvement isn’t to sacrifice more, more, more.

In fact, the best thing you can do, as you reflect on what didn’t work for you in 2025 is to ask:

If I wasn’t allowed to, once again, rely on willpower…
What would I be thinking about instead?

How would I approach things differently if I wasn’t allowed to sacrifice all my free time?

What would have to be true if I refused to attempt a “bootcamp”, and needed to find a forever sustainable approach?
Read 4 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Dec 10, 2025
The 3 practical ways to get healthier:

1. Getting leaner
2. Getting fitter
3. Getting stronger

Here’s what I mean by that:
Getting leaner means losing weight.

But more specifically, it means losing fat while protecting against muscle and bone loss.
Getting fitter means improving exercise capacity.

It’s also referred to as “improving cardio” or increasing endurance.
Read 7 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Nov 5, 2025
A short guide for new readers:

The number 1 cause of chronic disease, including heart disease, many cancers, Alzheimer's, dementia gout and (almost) anything you care to name, is poor metabolic health.

Let me explain:
Poor metabolic health is most commonly visible to the naked eye based on 2 factors:

-Excess body fat (being over fat, no matter the BMI)
-Low muscle mass (being under muscled, again, no matter the BMI)
The official term for poor metabolic health is insulin resistance.

My shortcut is this: the opposite of poor metabolic health = being lean and fit.
Read 5 tweets

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