It should be known that the biodistribution studies often referred to, by PHOs and doctors, that say "no fertility issues", "the spike doesn't stay in the body", as demo'd in this CDC slide, was based on rats.

🧵 Human Body biodistrib is detailed in "Clinics in Dermatology"
"Not surprisingly based on our identification of spike glycoprotein of presumptive human myocyte origin in cutaneous microvessels in vaccinated patients, the spike protein product of the mRNA vaccine is detectable in peripheral blood."
"13 Boston healthcare workers injected w/Moderna mRNA-1273 vaccine showed the S1 spike subunit in plasma beginning on day-1 and peaking at day-525. Although the S1 subunit became undetectable by day-14 as Ab levels rose, intact spike protein persisted much longer in a minority"
Regarding the blood distribution, in the 5-11 yo trial, kids in the vax arm were 9x more likely to have a blood disorder associated AE than those in the Placebo arm.

fda.gov/media/153409/d…
There are clinical trials ongoing with regard to Ovarian Reserve and Fertility that started in February 2021 - and are due to complete in February 2022.

clinicaltrials.gov/ct2/show/NCT04…
Rat biodistribution studies from Japan:
"up to 75% of the inoculum escaped the injection site and was found circulating in the blood and pooled in the spleen, liver, bone marrow, adrenal glands, ovaries, and other tissues30,31."

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More from @JeanRees10

22 Nov
Highly recommend this BMJ piece by Dr. Doshi.

Explores what the trial endpts could/couldn't tell us

Pfizer pop'd it's trials with young & healthy ppl. Not those who needed treatment the most, the older and comorbid

There were only 12 ppl 65+ in the Pfizer booster trial

🧵
Explores as the 💉 primary clinical endpt was "reducing symptomatic infection" & did not provide a statistically significant endpt on severe disease or death, can "it prevents mild disease" be bridged to severe disease or death?

bmj.com/content/371/bm…
Pfizer pop of adult trial:
65+ was 22%
65+ have been 79% of C19 deaths

75+ was 4%
75+ have been 57% of C19 deaths

21% of trial was w/1 or more comorbidity
96% of C19 deaths have had 2+ comorbids
64% of C19 deaths have had 6+ comorbids
Read 8 tweets
21 Nov
👀 @ Pfizer FOIA'd docs on AEs vs. then # of 💉 admin by age thru 2/28/21:

Those <18 have a ~4x greater chance of experiencing an AE. 18-30 - ~1.7x

These ages have a 99.99% survival rate from C19.
5,618 deaths on 127,129,500 ppl

⬇️ age, AEs ⬆️ risk was in clinical trl data
Vaxxed by age from CDC data as of 2/28/21:
Total -- 56.1 mil
75+ -- 13.7 mi - 24%
65-74 -- 16.1 mil - 29%
50-64 -- 10.9 mil - 19%
40-49 -- 5.8 mil - 10%
25-39 -- 7.8 mil - 14%
18-24 -- 1.8 mil - 3%
12-17 -- 77k - 0.1%
Under 12 -- 6k - .01%
Pfizer AEs by age -- data thru 2/28/21:
Total -- 42.1k
75+ -- 5.2k -- 12%
65-74 -- 3.1k -- 7%
51-64 -- 7.9k -- 19%
31-50 -- 13.9k -- 33%
18-30 -- 5.0k -- 12%
Under 18 -- 0.2k -- 0.4%
Read 4 tweets
18 Nov
Still haven't heard back from the @US_FDA on the mathematical errors in the Comirnaty BLA docs

The difference of 154 cases, (8 vax, 162 placebo) from which the VE was based on, could be completely wrong, based on this error

Putting the whole world wide roll out into question
When adding 2,285 + 2,636 that = 4,921

Also, when subtracting the neg results, that would leave:
Vax 2,285 - 2,026 = 259 -- Which is dif than the 303 referred to later
Placebo 2,636 - 2,305 = 331 -- Which is dif than the 396 referred to later

Total then would be 590 vs. 699
When adding the reasons:
Swab was not taken = Vax 210, Placebo 267 = 477
Swab was taken outside symptom window = Vax 80, Placebo 88 = 168
Swab was taken but results not available - Vax 13, Placebo 41 = 54

Total Vax 303, Placebo 396 = 699
Read 5 tweets
17 Nov
MIS-C post vax

Most of these cases would be considered:
"C19 hospitalization, unvaccinated"

per CDC definitions of 14 days post 2nd dose is "Vaxxed"

Is priming/immune suppression post dose making kids more susceptible to C19?

Pfizer had 18.2% VE up to 11 days post 1st dose
#1825618
12 yo female
13 days post 2nd dose developed MIS-C
4 Days in Hosp
Not stated whether prev C19 inf
wonder.cdc.gov/controller/sav…

#1822149
16 yo female
9 days post 2nd dose
Active C19 inf - 9 days after 2nd dose of 💉
Diagnosed w/MIS-C
6 days in Hosp
wonder.cdc.gov/controller/sav…
#1813648
12 yo female
26 days post 1st dose
Developed MIS-C in tandem w/C19 inf
5 days in hosp
wonder.cdc.gov/controller/sav…

#1804422
16 yo male
3 days post 2nd dose
C19 infection
Thrombocytopenia
MIS-C susp, but Ecoli found as well
Unknown days in hosp
wonder.cdc.gov/controller/sav…
Read 8 tweets
16 Nov
Highly recommend @GirardotMarc 's articles. He makes complex immunological processes understandable.

It should be noted in the FDA EUAs & at the 9/17/21 VRBPAC, Pfizer's Jansen could not establish a "correlate of protection" to Abs

At the 5:37 mark


🧵 Image
The case being made for boosters is based on waning antibodies. Something that vaccine manufacturers can't establish if there is a "correlate of protection" to.
Pfizer's Jansen quote:

“We actually looked at our breakthrough cases in our placebo-controlled phase 3 study, and have compared the antibody titers where we had the opportunity in individuals that got the disease versus the ones that didn’t,
Read 5 tweets
15 Nov
Pfizer 5-11 yo trial contained the buffer PBS

FDA allowed Pfizer to change the buffer to Tris for the public 5-11 yos. Never trialed

Now, let me take you on a thread where this gets super interesting, esp, in light of the administration errors, that @BearGauss highlighted

1/6
Here are the slides from the 10/26/21 VRBPAC where they say they used PBS for the Trial, but that the orange cap formulation coming out for 5-11 yos will contain Tris.

Tris is not in the 12+ Pfizer vaccines that has been deployed in the purple cap, PBS is.

2/6 ImageImage
In the FDA updated BLA/EUA they make a special point to say that PBS is not approved for 5-11 yos, only Tris is. So they trialed 5-11 yos with PBS, are sending untrialed Tris to the public 5-11 yos.

3/6 Image
Read 6 tweets

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