“There is quite convincing documentation that supports that the MEtabolic energy turnover is disturbed by #ME. By metabolic energy MEtabolism we mean the biochemical processes in the body, that transform, distribute and utilize energy sources in the food👇🏻 forskersonen.no/cellebiologi-k…
“Oxygen is the most important single factor for the cells' production of the important energy molecule ATP. The oxygen consumption of the muscle cells increases dramatically during physical work, but it has a limit. As the oxygen supply becomes insufficient, 👇🏻 #PwME #MEcfs
the production of lactic acid (lactate) increases, and then the working capacity of the muscle will rapidly decrease.” #MEcfs #PwME #ImmunoMEtabolism #ATP #KrebsCycle
“Most of us have experienced the "lactic acid feeling" with "sour" muscles during a hard workout. This is a feeling many ME patients say they recognize from everyday life.” #MEcfs #PwME #ImmunoMEtabolism
“At Harvard, researchers have measured the amount of oxygen in both the blood that goes out of the heart and what goes back to the heart. They found that more oxygen remains in the blood of ME patients during a physical test. The findings are published in the journal Chest.”#PwME
“This indicates that the oxygen is less absorbed by the muscle cells when the muscle is working. The most likely explanations are that the regulation of blood flow is less effective, or that there is a defect in the cells’ 👇🏻 #MEcfs #PwME #MedEd #IDPWD2021
“power plant", the mitochondria, which inhibits the cells' ability to consume oxygen.” #MEcfs #PwME #Mitochondria #ATP #IDPWD2021 #MedEd
“The result is in both cases that the capacity for oxygen-demanding (aerobic) energy combustion decreases, and thus the working capacity of the muscle. This means that the muscles will more easily switch to non-oxygen-demanding (anaerobic) energy metabolism and 👇🏻 #MEcfs #PwME
lactic acid production at a lower workload than normal, which is supported in several studies with ME patients, including conducted in Oslo and published in Physiological Reports: physoc.onlinelibrary.wiley.com/doi/full/10.14… @KatarinaLien #MEcfs #PwME #ATP #CPET #MedEd #IDPWD2021 #ImmunoMEtabolism
What does our research show?
We in the ME research group in Bergen and others have made extensive analyzes of the biochemical composition in blood samples from ME patients (#PwME), which has also been mentioned on forskning.no Prof. @kjtronstad 👇🏻 #IDPWD2021 #MyalgicE
A Map of Metabolic Phenotypes in Patients with Myalgic Encephalomyelitis aka Chronic Fatigue Syndrome @kjtronstad et al #MEcfs #PwME #ImmunoMEtabolism #IDPWD2021 #MedEd insight.jci.org/articles/view/…
“The results from such analyzes are difficult to interpret, but they can provide a snapshot of what is going on. For example, we have found specific effects that may be associated with insufficient oxygen supply in some places in the body of ME patients,👇🏻 #MEcfs #PwME #IDPWD2021
which will be in line with the findings in the section above. In addition, we see certain patterns that indicate adaptations and reactions to prolonged energy stress in the body, especially when it comes to the blood's transport of energy sources such as amino acids 👇🏻 #MEcfs
and various fats (eg fatty acids and triglycerides). These adaptations may be influenced by individual factors in the patients, and this may explain why the levels of related molecules vary somewhat within the ME group.” #MEcfs #PwME #ImmunoMEtabolism #IDPWD2021 #MedEd
“With this, several biochemical characteristics have been found that will fit into a connection with the underlying chronic energy disorder in #PwME. Persistent disturbances in energy metabolism can also contribute to fatigue and lack of effect of rest and sleep,👇🏻
by weakening recovery mechanisms both in muscle and elsewhere in the body.” 👇🏻 #MEcfs #PwME #ImmunoMEtabolism #MedEd #IDPWD2021
“In studies where ME patients are physically tested over two days, it has been seen that ME patients respond differently compared to healthy individuals, including that they have increased lactic acid production on day two.” #MEcfs #PwME #CPET #ATP #MedEd #IDPWD2021 #Mitochondria
🖼 “Perhaps it is the case that the ME patients are metabolically in a continuous chronic training session, even when they are resting.” Prof. @kjtronstad @UiB @PutrinoLab @4Workwell @sunsopeningband #MEcfs #PwME #ImmunoMEtabolism #MedEd #ATP #IDPWD
“There is good evidence that ME patients have changes in the immune system, and we are currently investigating a hypothesis that ME may be due to an autoimmune disease mechanism that affects the regulation of the blood supply.” #PwME #MEcfs #Autoimmunity #ImmunoMEtabolism #MedEd
“When the muscle is working, the blood supply is normally adjusted by so-called self-regulation of the blood vessels, and it is conceivable that autoimmunity may be directed at this mechanism. Further research is required to assess whether this can be true.” #MEcfs #PwME #MedEd
“There are thus good arguments that chronic disease mechanisms cause persistent physiological stress in the ME patients, which may explain activity intolerance and worsening of symptoms in connection with exercise.” #MEcfs #PwME #MedEd #IDPWD2021

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