1/ Not surprisingly, a longer delay between 1st & 2nd doses of mRNA COVID vaccines (i.e. 6-7 weeks rather than 3-4 weeks) results in better immune responses.
jamanetwork.com/journals/jama/…
jamanetwork.com/journals/jama/…
2/ Did we do the right thing sticking to 3-4 weeks between doses earlier in the pandemic?
I'd argue yes. Early in 2021, we were facing the threat of the Alpha variant.
We were trying to fully protect as many as quickly as possible.
I'd argue yes. Early in 2021, we were facing the threat of the Alpha variant.
We were trying to fully protect as many as quickly as possible.
3/ And then, of course, the Delta variant came on its heels... even more infectious than Alpha.
4/ But now, does it still make sense to give the 2 doses of Pfizer and Moderna vaccine 3-4 weeks apart?
I'd argue no.
For people just starting their vaccination series (including kids), they might not need a 3rd dose if we simply space their 1st & 2nd doses out a bit more.
I'd argue no.
For people just starting their vaccination series (including kids), they might not need a 3rd dose if we simply space their 1st & 2nd doses out a bit more.
5/ More on this here: ncbi.nlm.nih.gov/pmc/articles/P…
Antibody levels are slightly higher with a longer delay between 1st & 2nd doses of vaccine, but a long delay before the 2nd dose brings risks associated with less strong protection during that period.
Antibody levels are slightly higher with a longer delay between 1st & 2nd doses of vaccine, but a long delay before the 2nd dose brings risks associated with less strong protection during that period.
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