Apparently now they are going to change the definition of "leaky vaccine" along with "herd immunity" and "vaccine" to that it "reduces" infection and transmission instead of "prevents" it?
healthline.com/health-news/le… "“These vaccines also allow the virulent virus to continue evolving precisely because they allow the vaccinated individuals, and therefore themselves, to survive,” said Venugopal Nair, who led the research team...
"These less-than-perfect vaccines create a “leaky” barrier against the virus. Vaccinated individuals may get sick but have less severe symptoms, but the virus survives long enough to transmit to others, which allows it to survive and spread throughout a population....
"“Our research demonstrates that the use of leaky vaccines can promote the evolution of nastier ‘hot’ viral strains that put unvaccinated individuals at greater risk,” Nair said. This is all BASIC VIROLOGY. It is a hypothesis that cannot be eliminated a priori.

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More from @ToddZywicki

8 Dec
Another early and important paper on NI, vax, and boosters from the canary in the coal mine (Israel). Some novel and original data here on so-called "hybrid immunity" (the first I've seen at least). medrxiv.org/content/10.110…
Baseline finding reaffirms yet again uncontestable conclusion: NI provides superior and far more durable protection against infection than vaccination. Protection of NI at 8-10 months is equivalent to vax at 0-2 months and protection of NI at 12+months to vax at ~3 months. Image
Figure 3C is booster data. Authors definition of "Booster" is interesting: "Booster: Individuals who received a third (booster) dose 12 or more days previously and had not been infected before the start of the study period." Why 12 days?
Read 11 tweets
7 Dec
pubs.acs.org/doi/10.1021/ac… "By tracking the evolutionary trajectories of vax-resistant mutations in more than 2.2 million SARS-CoV-2 genomes, we reveal that the occurrence and frequency of vaccine-resistant mutations correlate strongly with the vax rates in Europe and America."
Image
"Moreover, from Figure 4, one can see that the frequency of the Y449S mutation has a tendency to increase similar to that of the fully vaccinated ratio...
Read 8 tweets
6 Dec
Paper on the efficacy of vaccine passports at limiting transmission. medrxiv.org/content/10.110… Conclusion: "The transmission risk reduction gained by excluding unvaccinated people is
very small for most settings."
They develop a metric of "Net Needed [unvaccinated] to Exclude" to prevent one infection: "healthcare (NNE=4,699), work/study places (NNE=2,193), meals/gatherings (NNE=531), public places (NNE=1,731), daily conversation (NNE=587), and
transportation (NNE=4,699)."
In other words, it would be necessary to exclude 4,699 unvaccinated people from healthcare facilities to prevent one infection. Needless to say, there would be substantial cost from exclusion as well.
Read 9 tweets
1 Dec
"Although it is not the Courts duty to ask whether CMS’s decision was “the best one possible” or even whether there were “better [] alternatives,” the
Court must ensure there exists a “rational connection between the facts found and the choice
made....
"As an[ ] example, CMS rejected mandate alternatives in those with natural immunity
by a previous coronavirus infection. But, elsewhere, it plainly contradicts itself regarding the value of natural immunity. Id. at 61,604 (“[A]bout 100,000 a day have recovered from infection....
Read 12 tweets
1 Dec
Louisiana v Bacerra content.govdelivery.com/attachments/MT… "The rejection of natural immunity as an alternative is puzzling. Natural immunity is the immunity of people who have been infected with the COVID-19 virus."
"In rejecting this alternative, the CMS Mandate stated:
While a significant number of healthcare staff have been infected with SARS-Co-V2, evidence indicates their infection-induced immunity, also called “natural immunity” is not equivalent to receiving the COVID-19
vaccine."
"The “evidence” CMS relied upon in rejecting that alternative is not provided."
Read 7 tweets
1 Dec
medrxiv.org/content/10.110…"We find evidence for increased risk of infection by the Beta, Gamma, or Delta variants compared to the Alpha variant after vax. In contrast to vax-induced immunity, no increased risk for reinfection was found in individuals with infection-induced immunity"
"We observed a larger effect of vaccination in the first 14-59 days after vaccination compared to 60 days and longer suggesting that the difference in VE between Delta and Alpha variant reduces over time since
vaccination, possibly due to waning immunity."
"Interestingly, we did not find a significant
difference between susceptibility to any of the investigated VOCs among individuals with immunity
due to a previous infection compared to naïve individuals. Also when stratified by time between
infections no differences are observed."
Read 5 tweets

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