A Moderna patent (US 9587003) filed in 2017 contains a DNA sequence that ended up being the unexpected insertion of the notorious Furin Cleavage Site (FCS) in SARS-CoV-2.
Its devastating effect on infectivity and transmission in the pandemic are well-documented.
Its devastating effect on infectivity and transmission in the pandemic are well-documented.
https://twitter.com/jhas5/status/1467497456778809351
Interestingly, Ralph Baric in the University of North Carolina (UNC) has tested vaccines for Moderna, and is also the world's expert in engineering hybrid versions of corona viruses.
No that couldn't possibly be connected ...
No that couldn't possibly be connected ...
There are 2 baffling aspects op the FCS insert: the presence of a Proline (P) which is suboptimal, and the CGG-CGG codon pair encoding two Arginine residues, which extraordinary rare (1 in 2 million).
Both features are found in this patent.
Both features are found in this patent.
The other significant point here is that the 19 nucleotide sequence was inserted in the SARS-CoV genome.
It is not a coincidental homology between to existing DNA sequences. It resulted from an active insertion process. The only 'natural' mechanism I can think of recombination.
It is not a coincidental homology between to existing DNA sequences. It resulted from an active insertion process. The only 'natural' mechanism I can think of recombination.
The main problem with the BLAST hit is that the homology with the MSH3 gene is in the antisense direction. So how can it act as a template for recombination?
Possibilities;
1. LncRNA transcribed from MSH3.
2. miRNA targeting it. There are 61 miRNAs for MSH3
Possibilities;
1. LncRNA transcribed from MSH3.
2. miRNA targeting it. There are 61 miRNAs for MSH3
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