Thread by @unlearnedhands

Good time as any for an update thread on some OTC pharmacological interventions against C19.

Niclosamide inhibits viral replication in human bronchial epithelium with an IC50 at orally hittable (~1g b.i.d.) concentrations.

journals.plos.org/plosone/articl…

For references on niclosamide oral hittability see also:

https://twitter.com/__ice9/status/1247000154185641989

Pulverized, it may even be possible to hit the IC90. Routinely taken at doses up to 2g and very well tolerated for short spans of time.

OTC in Europe & Asia, or online at niclosam dot com.

Ambroxol also hits 50% viral inhibition at extremely low concentrations, and in fact inhibition paradoxically decreases with increasing concentration. Very bioavailable. A little dab (~15mg oral t.i.d.) will do you.

doi.org/10.1101/2020.0…

Bromhexine (left panel above) is mostly metabolized to ambroxol and is more bioavailable, so it works just as well or better at ~8mg t.i.d.

https://twitter.com/__ice9/status/1285723614881427456

Also available OTC in Europe and Asia, or online at dpkitaoka dot com (search "bromhexine").

Combining the cathepsin inhibitor (niclosamide) and the serine protease inhibitor (bromhexine), yields near-total viral blockade:

>> "the combination of the CTPB inhibitor ... and the TMPRSS2 inhibitor ... reduced viral load to less than 0.01%"

doi.org/10.1016/j.omtn…

Both well tolerated, both very obtainable, and in conjunction likely still extremely effective against all variants. A bit pricey but IMO both worth stocking up on, still.

Makes a great Christmas gift!