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22 Dec, 4 tweets, 1 min read
#Novavax 3rd dose increased Omicron specific Anti-spike IgG to a jaw dropping 73.5 % !!! It blows every other platform out of the water. $NVAX
Correction - 73.5 fold not percent.
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The 73.5-fold increase was higher than for Pfizer and Moderna booster shots, which increased antibody levels 25-fold and 37-fold, respectively.

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More from @doctorvasan

vasan Profile picture
24 Dec
Scientific Basis for #Novavax #Covovax NVX-CoV2373 Superior Efficacy against broad range of Variants
Unlike the mRNA and adenovirus vaccines which only present a portion of the spike protein RBD (Receptor Binding Domain) to the immune system, Nuvaxovid presents the entire 1/9
“prefusion stabilized” Recombinant spike protein in a virus-like particle. The remainder of the spike protein apart from RBD’s in Nuvaxovid is also a site of neutralizing epitopes and that region is not heavily mutated in omicron.

NVAX (academic 2/9
collaborators actually) used a wild-type virus assay which means they used actual prototype and omicron viruses in the assays. They tested against the real deal. Moderna OTOH measured neutralization in a more common pseudo-virus assay – a non-coronavirus engineered to have 3/9
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