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Graham Pechenik Profile picture
@calyxlaw
Dec 29, 2021 • 14 tweets • 13 min read • Read on X
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New psychedelic inventions?

⁂ Phil Wolfson/KRF—ketamine for postpartum symptoms

⁂ Psilo Scientific—psychoactive & psychedelic fungus extraction

⁂ Cognigenics—5-HT2A “cognitive upgrade”

⁂ Liechti—MDMA response prediction

⁂ Small Pharma—DMT-type compound synthesis

1/14
…and more new psychedelic inventions?

⁂ Ixtlan—psilocybin for Alzheimer’s

⁂ Spirify—hydroxynorketamine analogs

⁂ Guangzhou Dazhou Biomedicine—transdermal ketamine

⁂ Disruption Labs—nanoparticle compositions

⁂ Daniel Lilly—“medicinal food products” with psilocybin

2/14
Ketamine Research Foundation (KRF)—“Ketamine for the Treatment of Postpartum Symptoms & Disorder”

First inventor Phil Wolfson

“treatment of all forms of emotional and psychological symptoms and disorders related to childbirth and its aftermath”

patentscope.wipo.int/search/en/deta…

3/14
Psilo Scientific:

🍄 “Extraction of Psychoactive Compounds from Psychedelic Fungus”

patentscope.wipo.int/search/en/deta…

🍄 “Methanol-Based Extraction of Psychoactive Compounds from Fungus”

patentscope.wipo.int/search/en/deta…

4/14
Psilo Scientific:

🍄 “Compositions Comprising Psychoactive Compounds From Psychoactive Organisms”

patentscope.wipo.int/search/en/deta…

🍄 “Methods & Compositions Comprising Psychoactive Compounds From Psychoactive Organisms”

1: appft.uspto.gov/netacgi/nph-Pa…

2: appft.uspto.gov/netacgi/nph-Pa…

5/14
Cognigenics—“Methods for Sustainable Human Cognitive Enhancement”

Using gene-editing “to lower the population of 5-HT2A receptors in the brain”

“temporary or permanent cognitive enhancement” that delivers a “persistent higher states of awareness”

appft.uspto.gov/netacgi/nph-Pa…

6/14
Liechti—“MDMA Response Prediction”

Dosing MDMA, MDA, MDEA, MDAI, mephedrone, methylene, & 3-MMC

Based on “patient characteristics” to produce “maximum positive subjective acute effects”

Sister PCT of published US app

No claims found inventive

patentscope.wipo.int/search/en/deta…

7/14
Small Pharma—“Synthesis of N,N-Dimethyltryptamine-Type Compounds, Methods, & Uses”

“an alternative method for the synthesis of DMT and DMT-type compounds...which avoids the use of problematic oxalyl chloride whilst producing high-purity compounds”

appft.uspto.gov/netacgi/nph-Pa…

8/14
Ixtlan Bioscience—“Psilocybin Treatment of Alzheimer’s Disease & Brain Pathologies”

Ixtlan AD Kit—“unique assembly of tools” to treat “a variety of brain pathologies by microdosing of encapsulated 5HT2A receptor agonists, specifically psilocybin”

prnewswire.com/news-releases/…

9/14
Spirify Pharma—“Hydroxynorketamine Analogues, Compositions Comprising Same & Methods of Use Thereof”

“HNK analogs and uses thereof in the treatment of depression, pain, inflammation, and other clinical indications”

All novel, none inventive

patentscope.wipo.int/search/en/deta…

10/14
Guangzhou Dazhou Biomedicine—“Transdermal Drug Delivery System for Ketamine”

Monolithic transdermal patches with ketamine drug-in-adhesive layer

And their use to treat depression, anxiety, and/or pain

appft.uspto.gov/netacgi/nph-Pa…

11/14
Disruption Labs—“Compositions for Supplementing Products with Therapeutic Agents & Methods of Use Thereof”

Nanoparticle compositions w fungus extract, kratom extract, Kanna extract, or kava extract, & incl psilocybin

All claims novel & inventive

patentscope.wipo.int/search/en/deta…

12/14
Daniel Lilly—“Medicinal Food Products & Method for Producing Said Products”

Cannabis & psilocybin “medicinal-infused food items” w extended shelf life

Cannabis & psilocybin:

🍨 ice cream

🥛 coffee creamer

🥤 drink product

🧀 cheese product

appft.uspto.gov/netacgi/nph-Pa…

13/14
Follow psychedelic patent applications with the @PsilocybinAlpha patent trackers:

psilocybinalpha.com/data

14/14

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More from @calyxlaw

Graham Pechenik Profile picture
Jan 19, 2023
What happens when two companies’ patents both cover the same drug?

Reunion Neuroscience’s lead RE104 = isoprocin glutarate, a prodrug of 4-OH-DiPT

Reunion $REUN has a granted patent claiming it

Today, Mindset Pharma $MSET received a notice of allowance on claims to it too

1/7
Field Trip $FTRP (the original applicant) obtained its patent on RE104 (then FT-104) after first w/drawing it from issuance to ensure examiner reviewed Mindset’s apps

Mindset’s were filed first, but only published after Field Trip’s app was allowed

Patent was allowed again

2/7
After Field Trip received its patent, Mindset filed a continuation application adding new claims

One of those claims is to isoprocin glutarate, Field Trip’s prodrug of 4-OH-DiPT

Today, that claim was allowed

Mindset paid the issue fee immediately

A patent will issue soon

3/7
Read 8 tweets
Graham Pechenik Profile picture
Jun 22, 2022
MDMA + LSD = a patentable invention?

According to the USPTO, yes

Today—MindMed $MNMD granted a US patent, with claims to:

“A composition comprising an empathogen/entactogen and a psychedelic in the same single oral dosage form.”

Along with methods of using it

🍬🤸🏻

1/9
What’s the patentable invention?

According to MindMed, that the entactogen & the psychedelic are in “the same single oral dosage form”

By contrast: “Recreational users use MDMA & LSD in separate dosage forms.”

A single dosage form ≠ “a single session of substance abuse”

2/x
But what about all the prior art on candyflipping?

Indeed—@_PortaSophia filed a third-party submission to challenge MindMed’s claims, citing 20 references

However, MindMed already split off this sister app, under accelerated examination program

It was allowed 1 week later

3/9
Read 9 tweets
Graham Pechenik Profile picture
Feb 2, 2022
All your vapes are belong to us?

New patent granted—“Delivery System for Ayahuasca-Like Substances”

Claims DMT vapes, 5-MeO-DMT vapes, & 2C-B vapes

These claims can be immediately enforced

1/6
The patent claims:

“A device for the delivery of a substance comprising:

a chamber comprising at least one vaporizable formulation wherein the vaporizable formulation comprises the substance and wherein the substance comprises one or more of”

DMT, 5-MeO-DMT, or 2C-B

2/6
The application was first filed as a provisional in July 2020

Did DMT vape pens exist in the prior art before the priority date?

This @doubleblindmag article was first published on Feb. 5, 2020:

3/6
 doubleblindmag.com/are-dmt-vape-p…
Read 6 tweets
Graham Pechenik Profile picture
Dec 31, 2021
Patentable pharmahuasca “kits of parts”?

New PCT app published: “Compositions & Kits of Parts Comprising N,N-DMT & Harmine & Their Use in Therapy”

“An alternative to ayahuasca that solves the problems of side effects…is pharmahuasca, also known as synthetic ayahuasca”

1/4
Applicant is University of Zürich, w inventors Dario Dornbierer, Davor Kosanic, & Milan Scheidegger

All are founders at Reconnect Labs: “a Spin-off of the University of Zürich…setting standards for a novel kind of ethical drug development company”

reconnect-foundation.org/reconnect-labs/

2/4
The PCT app claims:

–a “kit of parts” of DMT & harmine

–a composition of DMT & harmine

-their use to treat psychiatric disorders

None were found inventive

3/4
Read 4 tweets
Graham Pechenik Profile picture
Dec 30, 2021
New psychedelic inventions?

∰ Field Trip—tryptamine prodrugs

∰ Greenway DNA—personalized psychedelic treatment

∰ Small Pharma—deuterated DMT

1/9
Field Trip $FTRP: “Tryptamine Prodrugs”

Application covers diacid hemiester prodrugs of tryptamines & isotryptamines, eg, psilocin, 4-HO-DET, 4-HO-DiPT, & 4-HO-MiPT

Head twitch response & pharmacokinetics in rats & humans with 4-hemiglutarate & 4-hemisuccinate of 4-HO-DiPT

2/9
Is Field Trip $FTRP FT-104 a prodrug of 4-HO-DiPT?

In “Use in Treatment,” app discloses intramuscular & subcutaneous injection or oral tablet administration of:

N,N-isopropyltryptamine-4-glutarate (4-hemiglutarate of 4-HO-DiPT)

& subcutaneous “injectable formulation kit”

3/9
Read 9 tweets
Graham Pechenik Profile picture
Nov 20, 2021
Novel ketamine + psilocybin inventions?

New patent applications published:

𝔎 Celon Pharma—pulmonary administration of ketamine

𝔎 Univ Kansas—ketamine treatment for ALS

𝔎 Takeda Pharm—depression tx, after ketamine therapy

𝔎 CaaMTech—combinations of serotonergic drugs

1/6
Celon Pharma—“Ketamine Composition for Use in a Method of Treatment of Depression by Pulmonary Administration”

–inhalable dry powder ketamine compositions

–dosage regimens for their use “in a cycle of administrations of sequences of single doses”

appft.uspto.gov/netacgi/nph-Pa…

2/6
University of Kansas—“Ketamine Treatment for Amyotrophic Lateral Sclerosis”

Covers use of ketamine to:

–extend life expectancy

–increase number of days of survival

–reduce rate of deterioration of body weight

Claims all found novel & inventive

patentscope.wipo.int/search/en/deta…

3/6
Read 6 tweets

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