This thread by is going around
The numbers are not correct
We do not care about sensitivity against PCR -> We care about Sens against culturable/infectious virus
For that, rapid antigen tests are >90%
And the % infectious at day 5 used is inaccurate.
Its a nonsensical 🧵
The numbers are not correct
We do not care about sensitivity against PCR -> We care about Sens against culturable/infectious virus
For that, rapid antigen tests are >90%
And the % infectious at day 5 used is inaccurate.
Its a nonsensical 🧵
https://twitter.com/drandrekalil/status/1478307647996764160
Here’s an ex of why we can’t just use FDA numbers vs PCR
If we only compare vs PCR, you get poor sensitivity (here: ~400/800 or ~50%).
But if you compare viral loads that matter (culture pos), you get very high sensitivity: 93% here.
From medrxiv.org/content/10.110…
If we only compare vs PCR, you get poor sensitivity (here: ~400/800 or ~50%).
But if you compare viral loads that matter (culture pos), you get very high sensitivity: 93% here.
From medrxiv.org/content/10.110…
This is most commonly seen in asymptomatics. Why?
Because if asymptomatic - don’t have a clue if you’re PCR swab is taken when you are shedding live virus or Post infectious
So your just comparing Ag against anytime PCR positivity, regardless of if infectious.
3/
Because if asymptomatic - don’t have a clue if you’re PCR swab is taken when you are shedding live virus or Post infectious
So your just comparing Ag against anytime PCR positivity, regardless of if infectious.
3/
Further in the thread he says that 95% of people have cleared all infectious virus by day 5 from symptom start w Omicron
There is no data that shows that. On the contrary, with symptoms often coming on very early, many people may be at peak virus load at day 5
4/
There is no data that shows that. On the contrary, with symptoms often coming on very early, many people may be at peak virus load at day 5
4/
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