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7 Jan, 4 tweets, 1 min read
Viruses | Free Full-Text | SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron mdpi.com/1999-4915/14/1…
やった!229Eと同じだから注目してた挿入ins214EPEだ!

a new peptide EPEDLPQGF, gained for the first time due to the unique three amino acid insertion ‘EPE’ following position 214 in the S protein of Omicron, is predicted to bind strongly with two common HLA
alleles (HLA-B*35:01 and B*53:01) and weakly with four others (HLA-A*26:01, B*07:02, B*44:02, and B*51:01). This peptide may constitute a unique Omicron-specific T cell epitope, if confirmed to be targeted.
オミクロン特異的ではないんだな、これが。すでに潜伏している229E先輩も同じのを持っている可能性が高いんだな。

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More from @K9FCR

9 Jan
世界中の人々の健康に貢献したのなら、ノーベル賞は当然もらえるのだろうが、1-methyl-pseudouridineは、実は「悪魔の発見」だったのではないのか?第二のアインシュタイン?

苦難を越え、時の人に…mRNAワクチンの技術築いたカリコさん yomiuri.co.jp/science/202201…
私も昔、ヒトPMNでの、LPS活性本体であるlipid Aでのin vitro刺激によるTNF-α測定は実際にやってました。これ↓は免疫寛容というより免疫抑制!

ファイザーの実験的生物製剤が現実に人間の自然免疫を抑制するという論文 nico.ms/sm39871111?ref… #sm39871111 #ニコニコ動画
もう時効だろうからエピソードを話すと

当時の私は合成MDPとlipid Aを担当していて、BCG-primedマウスも使っていて、誤って自分の指に接種してしまったことも。BCG感作されていた私のPMNのTNF-α放出能は高すぎて実験には使えなかったのです。

つまり、BCGの強い免疫刺激を自ら実体験したのです。
Read 9 tweets

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