Vinay Prasad MD MPH Profile picture
Jan 8, 2022 27 tweets 5 min read Read on X
Great article, but I fear the CDC director is doomed. Here's why.

In the next few months, we will have to accept the inevitable, that all people will be infected with the virus at some point in the future. Better to be vaccinated/ or have nat immunity when you meet it...🧵
.. But avoiding it is not an option

Draconian mitigation efforts to delay the time to meet the virus make no sense.

Makes no sense for a vaccinated person to wear an n95 or equivalent. Certainly makes no sense, and is borderline insane, to make a child wear such a mask.
It is also borderline insane to make college students who have already had multiple vaccines keep getting more, or sit all day in their dorm room to avoid meeting it.

It is coming for them.

They're sacrifice won't change broader dynamics.
Mandating booster after booster is a fool's errand. It will target low risk populations, younger people who are working, and won't be the people you need to boost: nursing, home residents, and very old people.

You have no power over 80-year-olds to mandate.
By not having coordinated boosting in nursing homes, however, you are making a huge error.

What a screw up.

Boost nursing homes NOW!!!
If you feel fine, you will be asked to go to work. It doesn't matter if you would test positive by some test.

Some amount of infection is inevitable and cannot be avoided.

Collapse of social services & hospitals cannot happen.
So the CDC director will increasingly have to communicate policies that engage in trade-offs.

Balancing continuing society with trying to prevent local health care system collapse.
In many cases the right answer will be to ease up on your mandates, ease up on draconian policies, not double down on them.

This is when the CDC director will be in a jam
You see the CDC directors base is a group of online zealots who think the virus can be eliminated.

I'm worried they're going to take up hunting deer when they learn how many have SARS-CoV-2
The CDC director, who signed the John Snow memo, will have to communicate to them that the dream is dead. They won't like that. Just like they don't like 5 vs 10 days..
Thankfully, outcomes among young people are terrific. And yet, they are incredibly concerned with spread in young populations. So much so that they're willing to close schools. The only tattered ladder of opportunity left in this country.

Closing schools is catastrophic error
The CDC director is going to increasingly have to tell these people the truth.
That the virus will never be eliminated.
That it will eventually reach all people.
As such making a child wearing n95 or equivalent is a delusion.
It, at best, delays an inevitability, with loss of speaking and social cohesion, with no great gain. Should not be pursued.

Mandatory booster policies will also be unable to contain the virus. And thus the CDC director will have to eat crow.
Someone may someday ask if it made sense to boost 12-year-old boys with essentially no efficacy data...

Did it make sense to make the moderna booster 5 months with no day at all?
So the CDC director is in an impossible position. Having an embraced an ideology of zero COVID (John Snow), the CDC director will have to abandon it, and communicate policies that make compromises.
And thus, it is likely that the White House will sacrifice her. And they will be more infighting among the zero covid crowd
How can the CDC director save herself? The answer is clear: just tell the truth. That was always the secret.
If we told the truth about the efficacy of cloth masking, we would have had a lot more public trust.

If we told the truth that vaccines are tremendously effective for older people, but the risk benefit profile of multiple doses of younger people is dubious, we'd have had trust
More randomized trials and not fewer were the answer. We needed more randomized trials of masking in school. It's likely would have failed. But doubling down on rhetoric without doing studies is no good.
Even though Omicron is super contagious, it is possible that rich people are still making behavioral changes that will delay the time until they meet the virus. This will just lead to another peak in a few more months when they fatigue. Eventually all people will be exposed.
Optimize your medical problems, lose weight, get vaccinated, and get on with life. That was always the right answer. Everything else is a fools errand.

Good luck CDC director, you will need it.
Here is a long form explanation of why the n95 is pointless for a vaccinated person

vinayprasadmdmph.substack.com/p/should-you-w…
Oh. And, For all the people who think masks will keep flu away forever. Flu will find us all soon and it will punish us twice as bad for avoiding it.

There is no avoiding respiratory viruses. They only exist because we must be close to each other to truly live.
Here are the implications of this thread on schools
city-journal.org/school-closure…
Here are the implications fro vaccine mandates
vinayprasadmdmph.substack.com/p/vaccine-effe…

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More from @VPrasadMDMPH

Apr 10
Everything in this thread is incorrect. Literally every recommendation. Here's a thread why. 1/7
There's not a single randomized controlled trial that shows people who undergo a coronary artery calcium test live longer than those who do not undergo it. Everyone will benefit from increasing exercise and eating better and the score is irrelevant
Maybe the only cancer screening test that has any utility under 35 is the pap smear. Mammography doesn't improve survival at any age, and has no data in this age group. Totally crazy recommendation
Read 8 tweets
Jan 9
Glad that we @vkprasadlab have published over 20++ peer reviewed papers on COVID19 policy to date & many more to come

I will share them here & a free link to all of them at end

We see policy failure

#1 visitor restriction
It was sad to separate family from dying people, & had no dataImage
Cloth masking 2 year olds was an unforced error by @cdcgov and @AmerAcadPeds, who pushed this policy with no credible data, and despite its obvious silliness Image
Long COVID is an evidence based disaster
There is a strong narrative that is not well supported by the evidence.

To date, besides anosmia, there is no evidence COVID has any more long symptoms than being equally ill with any other respiratory virus. period. Image
Read 23 tweets
Dec 28, 2023
A new 22 page essay by Mariana Barosa, @ID_ethics and me!

"We argue that high-quality research, namely by means of well-designed randomized trials, is ethically obligatory before, during, and after implementing policies in public health emergencies"
🧵
link.springer.com/article/10.100…
Image
Our essay reimagines the status quo. Instead of implementing and deimplementing and never knowing the answer, Public health must work to reduce uncertainty.

Shown nicely in Figure 2 Image
We discuss many Non pharmacologic interventions tried and their limited evidence

This table represents an evidence based disaster. Nearly none of these were tested with proper trials
Forget beach closures and taking the swings out of parks Image
Read 9 tweets
Dec 10, 2023
When I read an #ASH23 abstract that asks whether PFS or MRD is a surrogate endpoint in FL (L) or CLL (R), I know instantly the person on the left did it right and the person on the right messed up

Want to learn how?
& diff btw
Prognostic, predictive & surrogate
#Tweetorial Image
When it comes to biomarkers there are 3 categories
Prognostic
Predictive &
Surrogate
#ASH23
jamanetwork.com/journals/jama/…
Image
A prognostic marker means that the marker is associated with a better or worse prognosis in a cohort of patients

For, e.g. HER2 is a poor prognostic feature in metastatic breast cancer

& in this CLL analysis
Having MRD is bad! (unsurprising)
#ASH23
ash.confex.com/ash/2023/webpr…
Image
Read 16 tweets
Nov 22, 2023
Small cell lung cancer is a horrible diagnosis, and I feel sadness for anyone who has it

A double lung transplant for small cell lung cancer is complete nonsense. @VUMChealth is just making things up. This story is so sad bc doctors want to practice on the island of Dr Moreau
Read 4 tweets
Nov 8, 2023
Just OUT! By @DavidBenjaminMD
We discuss evidence for STARTING & STOPPING cancer drugs!
What do I mean?
Currently in cancer med, we ~always start treatment at first sign of metastatic disease, and stop at progression, but....
🧵 (follow)
free link
authors.elsevier.com/a/1i2MQ7tJEDS6…
Image
... does this make sense?
The table shows trials testing early starting vs. delayed starting of systemic Rx.
For many diseases, there is no advantage to treating even widespread, asymptomatic disease
For most disease, however, there is no study at all!!
We truly don't know Image
But generally we assume. In many tumor types, we treat even asx or mildly symptomatic metastatic diseases (denovo or recurrent)

Now, lets consider the flip side of the coin. When should we stop treatment....
Read 10 tweets

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