Vinay Prasad MD MPH Profile picture
Jan 8, 2022 27 tweets 5 min read Read on X
Great article, but I fear the CDC director is doomed. Here's why.

In the next few months, we will have to accept the inevitable, that all people will be infected with the virus at some point in the future. Better to be vaccinated/ or have nat immunity when you meet it...🧵
.. But avoiding it is not an option

Draconian mitigation efforts to delay the time to meet the virus make no sense.

Makes no sense for a vaccinated person to wear an n95 or equivalent. Certainly makes no sense, and is borderline insane, to make a child wear such a mask.
It is also borderline insane to make college students who have already had multiple vaccines keep getting more, or sit all day in their dorm room to avoid meeting it.

It is coming for them.

They're sacrifice won't change broader dynamics.
Mandating booster after booster is a fool's errand. It will target low risk populations, younger people who are working, and won't be the people you need to boost: nursing, home residents, and very old people.

You have no power over 80-year-olds to mandate.
By not having coordinated boosting in nursing homes, however, you are making a huge error.

What a screw up.

Boost nursing homes NOW!!!
If you feel fine, you will be asked to go to work. It doesn't matter if you would test positive by some test.

Some amount of infection is inevitable and cannot be avoided.

Collapse of social services & hospitals cannot happen.
So the CDC director will increasingly have to communicate policies that engage in trade-offs.

Balancing continuing society with trying to prevent local health care system collapse.
In many cases the right answer will be to ease up on your mandates, ease up on draconian policies, not double down on them.

This is when the CDC director will be in a jam
You see the CDC directors base is a group of online zealots who think the virus can be eliminated.

I'm worried they're going to take up hunting deer when they learn how many have SARS-CoV-2
The CDC director, who signed the John Snow memo, will have to communicate to them that the dream is dead. They won't like that. Just like they don't like 5 vs 10 days..
Thankfully, outcomes among young people are terrific. And yet, they are incredibly concerned with spread in young populations. So much so that they're willing to close schools. The only tattered ladder of opportunity left in this country.

Closing schools is catastrophic error
The CDC director is going to increasingly have to tell these people the truth.
That the virus will never be eliminated.
That it will eventually reach all people.
As such making a child wearing n95 or equivalent is a delusion.
It, at best, delays an inevitability, with loss of speaking and social cohesion, with no great gain. Should not be pursued.

Mandatory booster policies will also be unable to contain the virus. And thus the CDC director will have to eat crow.
Someone may someday ask if it made sense to boost 12-year-old boys with essentially no efficacy data...

Did it make sense to make the moderna booster 5 months with no day at all?
So the CDC director is in an impossible position. Having an embraced an ideology of zero COVID (John Snow), the CDC director will have to abandon it, and communicate policies that make compromises.
And thus, it is likely that the White House will sacrifice her. And they will be more infighting among the zero covid crowd
How can the CDC director save herself? The answer is clear: just tell the truth. That was always the secret.
If we told the truth about the efficacy of cloth masking, we would have had a lot more public trust.

If we told the truth that vaccines are tremendously effective for older people, but the risk benefit profile of multiple doses of younger people is dubious, we'd have had trust
More randomized trials and not fewer were the answer. We needed more randomized trials of masking in school. It's likely would have failed. But doubling down on rhetoric without doing studies is no good.
Even though Omicron is super contagious, it is possible that rich people are still making behavioral changes that will delay the time until they meet the virus. This will just lead to another peak in a few more months when they fatigue. Eventually all people will be exposed.
Optimize your medical problems, lose weight, get vaccinated, and get on with life. That was always the right answer. Everything else is a fools errand.

Good luck CDC director, you will need it.
Here is a long form explanation of why the n95 is pointless for a vaccinated person

vinayprasadmdmph.substack.com/p/should-you-w…
Oh. And, For all the people who think masks will keep flu away forever. Flu will find us all soon and it will punish us twice as bad for avoiding it.

There is no avoiding respiratory viruses. They only exist because we must be close to each other to truly live.
Here are the implications of this thread on schools
city-journal.org/school-closure…
Here are the implications fro vaccine mandates
vinayprasadmdmph.substack.com/p/vaccine-effe…

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More from @VPrasadMDMPH

Nov 29, 2024
Here's what they are not saying
Vaccine hesitancy has been rising for some time. This includes preventable illnesses like measles. There will be measles outbreaks in the future! Covid policy accelerated hesitancy. The question is: how many extra outbreaks will occur bc of RFK...
... If RFK is HHS secretary, versus if RFK is not HHS secretary. That's the question.

Even though he has tremendous administrative authority, he has already stated he's not going to withdraw these vaccines. I also suspect it's not going to be the first topic he touches...
Moreover, I and others have repeatedly provided compromised positions where we can improve safety detection of current vaccines. The current system can be honest and admit that our vaccine surveillance is abysmal. Companies don't want safety discovered.
Read 9 tweets
Nov 22, 2024
Every single one of these garbage papers use the denominator of PCR+ covid infections, and not the actual denominator of people who had covid-- many do not present to the doc. Every single one of these papers is shit. I would be embarrassed to be an author. Incompetent work. Image
People with covid who are so sick they have to go to the doctor have poorer health than people who don't. That should be in the journal of obvious things. All of these authors are extrapolating beyond the evidence. They're creating a body of trash calling itself science
Is there a single paper that uses a sero prevalence denominator? Is there a single researcher in this field whose brain is working? Just one. That's all I ask for.
Read 7 tweets
Oct 3, 2024
Totally wrong. Because Vincent is not thinking about the counterfactual correctly.
*Teachable moment*

1 These drugs were approved by accelerated approval in the LAST line. Some later improved survival & others didn't in an EARLIER line.

2 The counterfactual to AA... 🧵
is demanding RCTs powered for say, OS (survival). If a company couldn't use RR to get AA, they wouldn't run a trial in the 2nd line or 3rd line setting powered for OS, they would run it in the 7th or 8th line

Why? more dire = faster result
3. We have proven that in these v late lines RR and median DOR (the current AA criteria) result just as fast as OS
pubmed.ncbi.nlm.nih.gov/30933235/
Read 10 tweets
Sep 29, 2024
Many people want covid to be worse than it is. They imagine it has long-term consequences that are worse than other respiratory viruses. Adjusting for severity of illness, it doesn't. Only anosmia is unusual. Why do they want it to be worse than it is? 🧵
For some reason, some people want to live with perennial precautions. They don't want to take off the mask, they want their children to mask, they want to keep getting booster after booster. I don't know why but they want to live in fear.
They have...
A mountain of retrospective observational data that they think supports their claim that covid has long-term disability. That it's a vascular disease. And all sorts of other claims. Nearly all these studies are flawed. They don't have good controls.
Read 15 tweets
Sep 25, 2024
I spent a lot of time today reading this paper, the criticism, the rebuttal, the retraction notice. OMG! My head hurts.

But... An important point no one has said is that the entire premise of the study & criticism is flawed. 🧵 Here is a short summary
Lots of prior studies show many psychological findings don't reproduce. Obviously that's because so much of this science is bullshit. Small sample size, weak methods. Entire fields struggling to justify their existence & people p hacking and exaggerating to be on @HiddenBrain
How do you fix this problem? No one really knows. All of academia is incentivized for hype and discovery, actually being a thoughtful student, criticizing things, pushing for better methods that's unpopular.
Read 17 tweets
Sep 14, 2024
Thank you @Erman_Akkus for ur reply it is a good learning opportunity for #ESMO24

In 15 tweets, I will summarize the trial, my criticism, and why this reply contains 3 common errors that oncologists make because our training doesn't teach these ideas.

First, the trial... Image
The trial is #LEEP-012 and randomizes pts with INCURABLE (see pic) liver cancer to TACE (embolization) plus costly drugs or embolization alone.

These 2 drugs are TOXIC (lenva is horrible) and cost a FORTUNE 200-300k per annum per person
#ESMO24 Image
Every single person has the cancer return. It is non-metastatic, as @Erman_Akkus says, but it is not curable.

Here is the time until measured lesions grow 20% or new lesions present or the patient dies

That's what he and others are excited by #ESMO24
a 4 months PFS Image
Read 16 tweets

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