1) AN ONCOGENIC “FLASH DRIVE”: THE SPIKE PROTEIN OF SARS-CoV-2 AND CANCER
When I first began studying the SARS-CoV-2 virus I was initially concerned about its Spike Protein’s potential ability to induce prion disease, as the spike has homology with our Prion protein and it
2) induces a strong Unfolded Protein response.
However, almost two years after I reached that conclusion, I believe it is only part of the story. Yes, I am still concerned that it may induce Prion Disease. But, what concerns me more is that its interactions and mimicking of the
3) human Prion Protein may be more “effective” having a role in tumorigenesis and metastasis.
In fact, the more I look at the Spike Protein now, and with the now common knowledge that the Spike Protein mimics Trousseau Syndrome, I now believe that the Spike Protein may be a
4) genetic “Flash Drive” capable of initiating and/or rapidly progressing cancers.
By looking at the Spike Protein’s interactome, we can see a landscape where it would seem inevitable that aggressive cancer would be initiated or an existing, perhaps even occult cancer, become
5) hyper aggressive.
TLR4
It has been determined that the Spike Protein interacts with TLR4. This is currently viewed as being involved with the onset of Sepsis in severe COVID-19. This is certainly true. However, as with much regarding this virus, nothing is ever as it initially
6) seems. TLR4, has been the center of attention regarding its contributory role in many inflammatory diseases including sepsis shock and asthma. Notably, mounting pieces of evidence have proved that this receptor is aberrantly expressed on the tumor cells and the tumor
7) microenvironment in a wide range of cancer types and it is highly associated with the initiation of tumorigenesis as well as tumor progression and drug resistance.
NEUROPILIN-1
The Spike Protein also interacts with Neuropilin-1. This is also an important receptor in the
8) development of cancer. Immunoreactivity for NRP1 was seen in vessels from normal tissues adjacent to cancer and in 98–100% of carcinomas. Tumour cell expression of NRP1 was also observed in 36% of primary lung carcinomas and 6% of primary breast carcinomas, but no colorectal
9) adenocarcinomas.
PRION PROTEIN
The Spike Protein bears homology with the human Prion Protein. It has been determined that PrPC misfolding and aggregation can cause fatal neurodegenerative conditions (98). Studies in recent years show that it also plays a role in cancer. PrPC
10) can stimulate cancer progression by promoting cancer cell proliferation, invasion/metastasis, drug resistance, and cancer stem cell development.
HEPERAN SULFATE
Another receptor that the Spike Protein interacts with. And yes, HS has important emerging roles in oncogenesis and
11) heparin derivatives represent potential therapeutic strategies for human cancers. Here we review recent insights into HS signaling in tumor proliferation, angiogenesis, metastasis, and differentiation.
ACE2
Obviously, the Spike Protein interacts with ACE2 and depletes it.
12) It may even induce autoantibodies against it. In the case of ACE2, upregulation was associated with favorable survival in pan-cancer and in multiple individual cancer types. These results suggest that ACE2 is a potential protective factor for cancer progression.
Given these
13) findings and the fact that the Spike Protein disrupts the endothelium, allowing it to invade virtually every organ, it may be the case that even an asymptomatic infection could induce an aggressive cancer. These words feel ominous as doctors throughout the world have been
14) reporting marked increases in cancers. Especially aggressive cancers. The Spike Protein appears to be a "Flash Drive" with a complete set of "instructions" to induce and/or accelerate hyper-aggressive cancers.
sciencedirect.com/science/articl…
ncbi.nlm.nih.gov/labs/pmc/artic…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Walter M Chesnut

Walter M Chesnut Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Parsifaler

10 Jan
1) COVID-19 COAGULATION ABNORMALITIES AS TROUSSEAU SYNDROME
IS THE SPIKE PROTEIN INDUCING GENERALIZED CANCER AND COULD THOSE IMMEDIATELY EXPERIENCING COAGULATION ABNORMALITIES HAVE OCCULT CANCERS?
Malignancy affects the hemostatic system and the hemostatic system affects
2) malignancy.
Cancer's "purpose" is to invade organs and disrupt their normal functioning by rendering cells dysfunctional. These dysfunctional cells then spread, disrupting further cells, and so on until the victim dies.
The way cancer accomplishes this is to spread through
3) vessels. If it spreads through blood vessels, it must cross the barrier of the blood vessels to enter organs, including blood vessels themselves. Therefore disrupting (activating) the endothelium is essential to "breaking through" that barrier.
The close relationship between
Read 11 tweets
9 Jan
1) Guild Navigator:
You are transparent. I see many things. I see plans within plans. (DUNE)
VASCULAR DISEASE AS CAMOUFLAGE: THE SPIKE PROTEIN OF SARS-CoV-2 AS MICROTUMOR
Respiratory disease held the world in a false awe at the beginning of the COVID-19 pandemic. Health
2) authorities the world over reiterated the same narrative: We have a new Respiratory Virus. Those of us who looked closely at the disease from the beginning knew that wasn’t the true picture – or at least not the full picture.
Then, slowly, over the course of the first year of
3) the pandemic, everyone else began to realize this, too. Finally, towards the end of 2020, COVID-19 was universally recognized as a Vascular Disease. However, I have realized the virus’ deception does not stop there.
IT IS ONLY A VASCULAR DISEASE INSOMUCH AS THE SPIKE PROTEIN
Read 17 tweets
8 Jan
1) AN EXPLANATION FOR THE SUDDEN CARDIAC DEATHS:
I believe the endocytosis of the Spike Protein is interfering with Ryanodine Receptors causing a calcium channelopathy resulting in Catecholaminergic Polymorphic Ventricular Tachycardia. This is a potentially fatal arrhythmia
2) which is induced when the heart rate exceeds 120 bpm.
The intracellular actions of the Spike Protein with Cathepsin L, a protease on the plasma membrane of host cells, increases Ca2+ release from the endoplasmic reticulum (ER) via the ryanodine receptors (RyRs). The associated
3) elevation of cytosolic Ca2+ concentration, in turn, increases cathepsin L activity. Cathepsin L promotes virus fusion with host cells by cleaving and activating the spike (S) protein. High levels of extracellular and cytosolic Ca2+ concentrations are also necessary for virus
Read 6 tweets
1 Jan
1) THE SPIKE PROTEIN OF SARS-CoV-2 RECOGNIZES THE BODY’S ENTIRE ENDOTHELIUM AS TUMOR ENDOTHELIUM. IT CAUSES THE BODY TO “TREAT” THE ENDOTHELIUM PRECISELY AS A CANCER THERAPY – BY DESTROYING IT WHILE CAUSING MASSIVE INLAMMATION AND IMMUNE CELL INFILTRATION.
First, let us look at
2) what Cancer does. Cancer wants an Anergic Endothelium. It wants an Endothelium which WILL NOT REACT. It will not cause the Endothelium to activate so that immune cells will not be “attracted” to it and remove it. It also wants to create new blood vessels to feed it.
3) This combination of “problems” it has can be easily remedied – by destroying it. Indeed, THIS IS A RECENT THERAPEUTIC UNDER DEVELOPMENT.
The following certainly is COVID-19. Would you not agree?
One important physiological function of normal endothelial cells is quiescence of
Read 16 tweets
31 Dec 21
1) A HYPOTHETICAL FATAL PATHOGENIC FEEDBACK LOOP OF THE SARS-CoV-2 SPIKE PROTEIN
Heretofore the global medical community has been mainly concerned with the Acute phase of COVID-19. This is in both aspects of treatment and prevention. However, I believe that the Acute phase of
2) COVID-19 is only the very tip of a massive pathogenic iceberg. And one that continues to “build” upon itself.
A paper published November 12 identified kidney disease as the leading risk factor for hospitalization in confirmed COVID-19 patients. The phenome-wide association
3) study also identified Type 2 Diabetes, Congestive Heart Failure, COPD in addition to Chronic Kidney Disease.
What is it that ties all of these diseases together? Please remember that Schizophrenia is also considered to be a major risk factor for severe COVID. All of the above
Read 7 tweets
27 Dec 21
1) My Christmas gift of understanding to the world. May it help.
Breakthrough. Finally. Mechanisms found.
Eexecutive (non-techincal) Summary: The Spike Protein of COVID-19 most likely cases the body to reject iteself.
COVID-19 mimics Graft vs Host Disease via Anti-Angiotenisn II
2) Type 1 Receptor Antibody induction and complement/immune complex deposition in the microvasculature mediated by the Spike Protein.
If you have been following my posts, you know that for the better part of the past year I have been focused on the observation that COVID-19 and
3) its sequelae look VERY MUCH like Graft vs Host disease. We see identical endothelial/multisystemic destruction in both COVID-19 and GvHD. However, as you know, I have been working to find the mechanism for this parallel.
I believe I can now explain why COVID-19 and GvHD are
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(