List of true things in 2022:

1. COVID is airborne
2. Wear N95s whenever you can outside home
3. Vaccines work, but ...
4. Need a booster to keep you out of hospital
5. Kids can and do get sick from Omicron
6. Long-term effects of COVID are serious
7. Hospitals are overwhelmed
8. Mass infection is not a sane health policy
9. Surgical masks are not enough when indoors
10. No therapeutic is a replacement for vaccines
11. Therapeutics are, however, needed
12. Don't trust politicians
13. MDs coordinating with government need to disclose such affiliation
14. Eating indoors is a bad idea these days
15. Variants are not guaranteed to end after Omicron
16. Do not gaslight those with #longcovid
17. Teachers are not babysitters for economy
18. Kids can and do wear N95s without issues
19. We need better ventilation in our societies
20. It's bad to spit in HCWs faces
21. ERs are not testing sites for COVID
22. Patience with HCWs is appreciated
23. HCWs are humans like you
24. HCWs are exhausted
25. Adhere with masking if visiting a hospital
26. You can talk on the phone with your mask ON
27. Vaccines are not experimental
28. Vaccine side effects do occur
29. Gaslighting those with vax concerns is bad
30. Vaccines are not perfect
31. Vaccines + booster save you from death
32. Robert Malone is a fraud
33. Natural immunity is not a replacement for vaccine
34. Sky is still blue most days
35. We all make judgement errors
36. Be kind to each other*
37. Accept criticism*
38. Correct course when needed*

*mental note to myself

Thanks for reading
We are all in this together
Things are bleak now
But be optimistic

Any other suggestions?

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More from @farid__jalali

12 Jan
Top 5 misinformation academic centers:
1. UCSF (Monica Gandhi)
2. UCSF (Vinay Prasad)
3. UCSF (Bob Wachter - "let's be over pandemic")
4. Brown (Ashish Jha)
5. Stanford (Jay Bhattacharya)

Did I miss anyone else?
Aaaah. Cannot wrap up the list without mentioning the one and only, the unrivaled:

6. Robert Malone University
Goes without saying, that absolutely remarkably brilliant and decent human beings work at all of these academic centers, who deserve a lot of credit for advancing the field in the past 2 years.

This is in no shape reflective of those hard-working and honest individuals.
Read 4 tweets
8 Jan
This is a reprint of the paper @cameronks @ThinkingCC @srrezaie and I wrote one year ago. The proposed pathophysiology secured a $2 million fund from US Gov't, with Cyproheptadine currently in a large multicentric RCT in US, and separately in Brazil

🔗papers.ssrn.com/sol3/papers.cf…
COVID-19 has inspired renewed interest in well studied but often overlooked concepts in critical care, including phenotypic variability in acute respiratory distress syndrome (ARDS) and the role of endothelial dysfunction in the propagation of acute lung injury.
We believe platelet hyperactivity, and the ensuing increase in platelet serotonin liberation, likewise urgently warrants refocused attention.

Prior studies suggest that in ARDS, platelets may exhibit a dysregulated state that exacerbates lung injury.
Read 69 tweets
28 Dec 21
Misinformation is misinformation. Whether it’s from any “front-line” organization, my own family member, or blue check marks that are deemed trustworthy by arbitrary criteria of a bird company.

We owe it to each other to fight misinformation wherever it comes from.
Sadly, there is evidence of coordination between political (WH) and economic (CEOs) forces and these blue check mark public health figures on Twitter.

The message being perpetuated by such “trusted” figures can and has been inaccurate and harmful to the public.

It’s shameful
As much as we fought the antivax positions of Malone and implied IVM-as-vax-replacement view of FLCCC, we should have the same urge toward some of these blue check marks

Their views range from anti-N95, to overpromising of vaccine efficacy, to harmful ideas toward HCW and kids
Read 4 tweets
27 Dec 21
🔥𝗧𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 vs prophylactic heparin in COVID improves outcomes if started early possibly by:

⏬platelet activation
⏬platelet microaggregates
⏬platelet-leukocytes aggregates
⏬platelet-erythrocyte aggregates
⏬rouleaux formation

pubmed.ncbi.nlm.nih.gov/34957811/
Heparin modulates platelet activity in COVID19

Basal (day 0) platelet activation severity determines fatal outcomes. By the time it's fatal, platelets are exhausted and hypo-active (no point initiating therapeutic heparin), elegantly demonstrated below:

Read 4 tweets
13 Dec 21
On IVM and “parasite” connection to SARS-CoV-2
Disclaimer: pure musings.

Clinically speaking, IVM has no identifiable role in management of COVID19 “the illness.”
How can this translate to #longhaul benefit seen in some with IVM?

ORF3a can be embedded into host cells for prolonged periods of time. I think autopsies from original SARS showed this. I have to read again. Very possible that if …
Read 6 tweets
12 Dec 21
Genuine question: if corners were cut and immunosuppressed subjects (who should have been excluded) were enrolled, could #molnupiravir usage conceivably result in mutations leading to the #OmicronVariant?

Exclusion criteria: clinicaltrials.gov/ct2/show/NCT04… Image
I realize this is a controversial and speculative, but Merck has the following exclusion criteria. Could financial incentives for recruiters or trial subjects have led to improper or unbeknownst recruitment of those who under mutagenic influence of #Molnupiravir led to #Omicron? Image
I mean there is a reason that Merck has put those exclusion criteria. Because it understands the possibility that such subjects cannot clear the virus and have months-yearlong shedding at times, and #Molnupiravir use can mutate it without being cleared.
Read 5 tweets

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