Karan Desai MD Profile picture
Feb 1 4 tweets 8 min read
Join now at #THT2022 as @HFpEF describes the results of the REDUCE HF-LAP II trial: the largest contemporary HFpEF device based trial.

Not the exclusion criteria for patients that may not tolerate a right sided volume load were defined by resting RA pressure, TR severity and PVR
This was a sick population with a median resting PCWP > 18. Meticulous definition of HFpEF with Exercise hemodynamics

The LA strain was quite low in both arms and could that affect who would respond @RBPatelMD?
To the results: as predicted there was no change in incidence of CVD ☠️ btw sham and IASD, but there was also not a difference in 🏥.

What accounts for this result?

This was a sick population overall and wonder if those w/ low LA/RA reservoir affected likelihood to respond

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More from @karanpdesai

Feb 1
Join now as Dr. Mann gives a keynote on HF in 2022 in the era of SGLT2i #THT2022

“Predicting the future isn’t what it used to be” - Yogi Berra

In era where definitions of HF are becoming blurred, how do we define the role of therapies? A talk pertinent for all cardiologists
Followed by @NirUrielMD talking about the future of HF and pointing out this fantastic paper from @HRRosenblum on a device-based approach to ADHF w/ the DRI2️⃣P2️⃣S approach

Read paper here: ahajournals.org/doi/full/10.11…

@BrenerMickey @ersied727 @zilgiovineMD @tremartyn @AHajduczok
What a whirlwind tour by @GreggWStone on how the sausage gets made with HF device clinical trials

Look at all the factors: critical background on understanding how the evidence forms for the science we apply at the bedside

@mvaduganathan @FudimMarat @vbluml @SJGreene_md
Read 5 tweets

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