I will share a few shots of some messages & recs as it is behind paywall
Selectivity is unavoidable. It is 50 pages!
2/These are the key messages of the Commission
3/The Commission does see the opioid overdose/poisoning crisis as a result of a multi system regulatory failure
4/The commission does recommend opioid agonist treatment but offers caveats in maximum or unmanaged supply
5/The Commission recommends sensitivity toward patients with pain
6/The Commission offers support for PDMPs.
Ed note: I use one. It can be helpful. I am concerned that these mandatory systems are not open to appeal or correction by patients and that my patients are adversely and incorrectly labeled by the PDMP due to receiving team based care
7/The Commission quotes patients and prescribers on opioids and pain, commendably
8/The Commission quotes people in recovery, which I think is helpful here
9/The Commission makes a strong case for financing and expanding accessible, high quality, non-stigmatizing health and social care services for people with opioid use disorder
10/The Commission gives attention to criminal justice system involvement as a situation where there should be a maximizing of benefit and minimizing of adverse effects
. (I refuse to put that “s” in for the “z” cause I’m tweeting in ‘Merica , f- yeah!)
11/There are hundreds of citations and far more I have not summarized.
Full panel of recommendations here.
If a person lacking Lancet access reaches out to me personally I will share the article under fair use / fin
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🧵1/Our @uabmedicine Grand Rounds will feature a diagnostic showdown between Dr Martin Rodriguez and ChatGPT4
I am scared here because I don’t want AI to win
2/the case features behavioral changes, swearing, cognitive decline, cough, progressive weakness over 3 years.
I wonder about infectious and rheumatic disorders. Maybe primary neurological
Aspirations after a cognitive change is possible
Dr Rodriguez opens. Not much to go on.
3/ChatGPT generated a lot of text read by Dr Kraemer but it is pretty good, with emphasis on neurological disorders followed by a disclaimer “please note that this does not substitute for professional medical advice”. Both want more information
Truth💣 1/ The “NARXCare” opioid Rx risk algorithm is in all Prescription Monitoring Databases,ie ~1 bn Rx’s/year
NOW in @JournalGIM
✅evidence does not yet exist to support it as safe or protective
✅It has flourished due to lack of federal oversight link.springer.com/article/10.100…
2/The authors, led by Dr Michele Buonara, review the core argument as one in which this algorithm with low evidence to its favor
and high risk of harm
has gone unregulated
despite apparently fulfilling @US_FDA criteria that mandate it be regulated
3/Nearly all prescribers and national pharmacies now see the Bamboo Health, Inc proprietary “NARXcare” algorithm in a more prominent position *than the prescription history itself” when they view a prescription history.
1/Arguing for methadone deregulation, Dr. Ruth Potee notes that in an auditorium of 400 addiction specialists, almost NONE prescribe methadone (because they can't)
"Methadone is a miracle drug that no one has access to"
There are more people who offer Botox than offer methadone
Patient: “I can still do my activities”.
Doc: "No way, not really. I read the SPACE trial, and there is NO benefit (that would outweigh the opioids’ risk)”
"Shared decision-making" seems *doomed* here
1/I watch with concern as DEA prosecutions of MDs still seem to rely on “they prescribed more than I would” despite a 9-0 ruling of
Supreme Court last year
Sudden termination of opioids & progressive abandonment of 5-8 million patients is dangerous
1/Even on inpatient rounds, it is possible to introduce the idea that addiction isn’t (only) in the brain.
I contrast @NIAAAnews “brain disease” against a behavioral economics vide substance use as a pattern of behavior occurring in relation to environmental context
2/On teaching rounds we read aloud and discussed the @NIAAAnews brain-science model of addiction, pulling just a few lines off their website
3/then we read lines from Chapter 39 of “Evaluating the Brain Disease Model of Addiction” - this presents harmful substance use as a pattern of behavior based on assessment of competing rewards, delay or uncertainty of desired rewards, risks and costs - ie behavioral economics