Preprint on COVID human challenge study clarifies some much debated questions. This shows viral load by PCR (blue) and live virus (red) following infection - virus comes up first in throat but reaches higher level in nose. (1/4). researchsquare.com/article/rs-112…
A positive rapid antigen test appears to be a pretty good reflection of live virus shedding (black bars) (2/4)
Comparing the timelines of symptoms to virus shedding fits the idea that you can spread the virus when asymptomatic (green = "just noticeable", yellow = "bothersome some of the time") (3/4)
Note, the original strain was used for this study, not Omicron. A low infectious dose was used, resulting in ~50% of the subjects becoming infected. Volunteers were 18-29 years old and there were no severe illnesses.(4/4).
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My first tweetorial! On our new #InnateImmunity and viral interference study @JExpMed. It started with puzzling observations that pointed to the importance of kinetics. We saw a robust interferon response in the upper airway in all COVID patients studied, mild and severe:
..But these samples were from different times in the disease course. To get at timing, we studied serial swabs from patients picked up early in infection, when the viral load was still going up. We measured virus and CXCL10, a biomarker of the interferon response…
…both went up, then down, almost perfectly in synch… except for lag in the antiviral response in the first few days of infection. Replication in the first few days was exponential and fast! (avg. doubling time 6 hr)....