Joseph Allen Profile picture
Feb 24 4 tweets 2 min read
Great to see this profile of terrific colleague and friend @CellDeathLab and his team.

—> “lungs of the elderly offer up many more targets for the virus to latch onto compared with young lungs, which could help explain the sharp disparities in disease severity by age.”
I’ve been flagging this paper since it was a preprint. Can’t stop thinking about it. Some people had ‘almost no’ ACE2 gene expression?!?
Line of research also starts to get into potential mechanism for why kids fare better than adults.

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More from @j_g_allen

Feb 25
"just about every building you’ve ever walked into is underventilated with low levels of filtration. That’s b/c the standard that governs ventilation rates is a bare minimum not designed for health."

We need Operation Warp Speed for clean *indoor* air
🧵
thehill.com/opinion/energy…
When we think about the full suite of tools we need to combat covid, now and in the future, we’ve had many successes - vaccines, therapeutics, rapid tests. But amid all these achievements, one of the most important and needed has been ignored: good ventilation and filtration.
2/x
How much of a non-focus are ventilation and filtration? We don’t even include an assessment of the building systems in our outbreak investigations, as our Lancet COVID-19 Commission report pointed out should be done every time.
3/x
Read 20 tweets
Feb 6
What do crypto, gamestop, and NFTs have in common? Read these 3 articles, then you’ll know (hint: the short answer is in the penultimate sentence in one of them)

@jodyrosen @mccabe_caitlin @amandamull

🧵
Read 4 tweets
Feb 4
The importance of wastewater for routine surveillance is gaining traction. Two new tools just got released yesterday 🧵

1. National Wastewater Surveillance System dashboard

(It’s a start. Best part is there are plans to expand this across the country)
2. The company that’s been leading the charge on wastewater surveillance, @BiobotAnalytics, also released a new dashboard yesterday:
Read 8 tweets
Jan 14
Relying on the 2020 playbook as we head into 2022 is as foolish as relying on the 2019 playbook as we entered 2020. The game has changed. Given the availability of vaccines, here are 10 updates to the playbook for 2022 (from 12/15. Still holds.)

🧵

washingtonpost.com/opinions/2021/…
1: “Fully vaccinated” should mean you’ve received a booster shot.

Your body needs to “see” the signature of this virus again to restore protection against the delta and omicron variants.
2: Stop equating all control strategies.

Haphazardly providing the public with a long list of controls without any order or logic is confusing and harmful.
Read 13 tweets
Jan 11
8 degrees in Boston. No outdoor activities at school.

My 9 year old: "So no mask breaks today? That's worse than freezing."

Don't tell me 2 years of masking doesn't impact kids. Their risk is low, vaccines avail for all adults and kids, anyone who wants can mask. It's time.
Read 10 tweets
Jan 3
Make no mistake, the costs of closing schools is high. Too many have gotten casual about this.

A thread.

nytimes.com/2021/12/20/opi…
"Even short-term closings have steep consequences. Schools are the place where we first detect trouble at home, including neglect and abuse."
"An analysis of data from New York City found a drop of nearly 8,000 in expected reports of allegations of child maltreatment. When researchers extrapolated that to the rest of the country, they estimated that more than 275,000 cases would have otherwise been reported."
Read 14 tweets

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