Thread by @BasuNephro

#ISNWCN @ISNWCN @ISNkidneycare Theme Symposium: New Kids on the Block to Treat #DKD and #CKD.
@Heerspink79 : GLP1 agonists and SGLT2i in limiting DKD progression.
SGLT2 inhibitors reduce progression of CKD. Degree of albuminuria reduction - determinant of benefit.
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#ISNWCN New Rx #DKD and #CKD @Heerspink79
Do GLP1 agonists help retard DKD progression?
- Semaglutide ⬇️ UACR in DKD
- Exenatide⬇️ eGFR decline more in those with higher proteinuria
- Dulaglutide ⬇️ CKD progression in DKD
- FLOW: study of semaglutide in DKD recruiting
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#ISNWCN New Rx #DKD and #CKD @Heerspink79 Should we use SGLT2i + GLP1antagonists together?
- Combination reduces albuminuria more than either alone
*Novel GLP1 + glucagon agonist*
- Significantly reduced HbA1c, body weight and CV outcomes.
Large RCT - initiated soon
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#ISNWCN New Rx #DKD and #CKD @Heerspink79
KDIGO DKD guideline 2020 recommends metformin with SGLT2i as first-line therapy. Maybe GLP1 agonists will enter this space in the future.
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