Nick Mark MD Profile picture
Mar 8, 2022 18 tweets 10 min read Read on X
Here’s a situation many of us have seen in the ICU or ED: “It looked like there was ST elevation on the monitor but when I took a 12 lead it was gone?!”

A STEMI went MIA? Here’s a #tweetorial all about why ST segments look different on monitors.

#FOAMed #FOAMcc
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First, here’s another great example of "disappearing ST elevation", from Dr. Smith’s ECG Blog @smithECGBlog

(If you don’t already you should definitely follow Dr Smith & bookmark his site; hqmeded-ecg.blogspot.com IMO it's the best site for ECGs; you can thank me later)
2/ Image
In order to understand *WHY* the ST segment looks different, we need to know how an ECG works & understand just a little bit of electronics & math.
(Don't worry, I promise no equations or circuit diagrams 🤞)
3/
First, we need to understand how an ECG works:
We use a pair of electrodes to measure the difference in electrical potential between two points on the body. We call this pair a “lead".

For example the left and right arm form lead I.

This was true in 1911 & still is in 2022.
4/ ImageImage
But there’s a problem: NOISE

Muscle movement/shivering, breathing, baseline wander, & other artifacts can interfere with the EKG signal.

All these types of NOISE would make the EKG almost useless for continuous monitoring.

But fortunately there’s a solution: FILTERING.
5/ From: Sivaraks & Ratanamaha...
Modern ECG monitors use *FILTERS* to remove much of the NOISE.

A bandpass filter allows only certain frequencies to pass:
Blocking low frequencies (<0.5Hz) removes respiration & baseline wander
Blocking high frequencies (>40Hz) removes most muscle twitches & AC interference
6/ Image
Summary:Bandpass filters remove low frequency (respiration, baseline wander) & high frequency noise (muscle twitches, AC interference, etc) so we get only a perfect clean ECG signal?

Sounds great right?

Well…there’s a catch: Removing NOISE alters the SIGNAL.
7/
To understand why FILTERS alters the signal, we need to review just a teeny bit of math:

It turns out that you can represent *any* complex waveform as a summation of simple sine waves.

For example, look how we can make a sawtooth wave by combining 15 sine waves together👇
8/
This means that even a complex ECG waveform can be made by combining a bunch of sinusoidal functions of different frequencies (or harmonics).

Check out how they Fourier transformed an ECG into harmonics then put those harmonics back together 👇
hindawi.com/journals/isrn/…
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🤓 Sidenote: the mathematical name for these sinusoidal functions is a phase vector, usually called a “phasor” for short
That means that when you get an ECG you are really just combining sinusoids, or you could say a “Set of Phasors to Sum”
💥Zing
I’ll show myself out…
10/
The problem is we *NEED* some of those high & low frequency sine waves to make a proper EKG waveform.

The bandpass filters that removed pesky noise also took out some of the signal.

➡️Thus Filtering alters the ST segments!
Checkout how a 0.5Hz filter alters the same ECG:
11/ ImageImage
🔑 Point: Because of ECG filters, the ST segment is unreliable on a *MONITORING* ECG
This is why you must always obtain a *DIAGNOSTIC* ECG to properly evaluate the ST segments.

(If I teach you only one thing, remember the memes!)
12/ ImageImage
Clinical 🥡:
MONITORING ECGs (boxes people are constantly attached to) are used continuously for *rhythm determination*
DIAGNOSTIC ECGs (the thing rolled in, often called “a 12 lead ECG”) should be used for detailed ECG interpretation including analysis of the ST segments
13/ ImageImage
In case you are wondering, this is why patients must “hold still” for diagnostic 12 lead ECGs but the monitoring ECG often looks OK despite movement.

This also explains the Hz number on the bottom left of every ECG printout.
14/ ImageImageImage
A few more details about filters in ECGs:
- *DIAGNOSTIC* ECGs are typically 0.05 to 150 Hz
- *MONITORING* ECGs are typically 0.67 to 40 Hz (sometimes 0.5 to 50 Hz); narrower frequency range means less noise but also less reliable ST segments.

medteq.net/article/2017/4…
15/
Some OR monitors have an even more filtered “surgery” mode (1-20 Hz) to remove electrical interference from Bovies

This highly filtered mode can cause some serious artifactual ST elevation as shown in this case report & reply by the manufacturer.
…-publications.onlinelibrary.wiley.com/doi/epdf/10.11…
16/ ImageImageImageImage
🥡 Summary:
-unlike diagnostic ECGs, monitoring ECGs are highly filtered to remove noise
-filtering removes noise but also alters the ST segment; don’t trust ST segments on monitoring mode ECGs!
-ALWAYS obtain a diagnostic 12 lead ECG to properly evaluate the ST segment
17/17
Bonus fact:
Modern Fancy monitors allow continuous ST segment monitoring.
These monitors measure STE/STD in realtime & display it as number.
The displayed waveform is still filtered so you can trust the numbers but NOT what the ST segment looks like.
If in doubt get a 12 lead. ImageImageImage

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More from @nickmmark

Oct 1
New favorite physiology paper: Central Venous Pressure in Space.

So much space & cardio physiology to unpack here including:
- effects of posture, 3g shuttle launch, & microgravity on CVP
- change in the relationship between filling pressure (CVP) & LV size
- Guyton curves!
1/

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To measure CVP in space they needed two things:
📼 an instrument/recorder that could accurately measure pressure despite g-force, vibration, & changes in pressure. They built & tested one!
🧑‍🚀👩‍🚀👨‍🚀 an astronaut willing to fly into space with a central line! 3 volunteered!
2/
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The night before launch they placed a 4Fr central line in the median cubital vein & advanced under fluoro.

🚀The astronauts wore the data recorder under their flight suit during launch.

🌍The collected data from launch up to 48 hrs in orbit.
3/
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Read 16 tweets
Jul 16
The media silence on this is deafening.

Did he have a head CT? What did it show?
Did he have stitches? Tetanus shot?

The NYT ran nonstop stories about Biden’s health after the debate but can’t be bothered to report on the health of someone who was literally shot in the head?
To the people in the replies who say it’s impossible because of “HIPPA”
1. I assume you mean HIPAA
2. A normal presidential candidate would allow his doctors to release the info. This is exactly what happened when Reagan survived an assassination attempt.
washingtonpost.com/obituaries/202…
My advice to journalists is to lookup tangential gunshot wounds (TGSW).

Ask questions like:
- what imaging has he had?
- what cognitive assessments?
- has he seen a neurosurgeon or neurologist?
- he’s previously had symptoms like slurred speech, abnormal gait - are these worse?
Read 4 tweets
Jun 30
You've probably heard "don't give lactated ringers because it raises lactate"

This statement is ~98% false, but there's one crucial practice-changing fact that you need to know.

A 🧵 all about lactic acid and lactated ringers!
1/
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First off, we should ackowledge the obvious: Lactated ringers does in fact contain lactate... 28 mEq/L in fact

BUT there's one little detail to remember:
Lactate ≠ Lactic acid

When we measure "lactate" we care about the ACID (H+) which lowers pH & causes organ dysfunction
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But the correlation between pH & lactate is really bad!

Look at this analysis of lactate vs pH in 171 ICU patients.

There is a *weak* correlation in people with arterial lactate > 5, but even w/ lactate =10, pH ranged from 7.5 to 7.05. Quite a spread!

3/ ncbi.nlm.nih.gov/pmc/articles/P…
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Read 10 tweets
Jun 13
If you intubate you need to read the #PREOXI trial!
-n=1301 people requiring intubation in ED/ ICU were randomized to preoxygenation with oxygen mask vs non-invasive ventilation (NIV)
-NIV HALVED the risk of hypoxemia: 9 vs 18%
-NIV reduced mortality: 0.2% vs 1.1%

#CCR24
🧵
1/

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Hypoxemia (SpO2 <85%) occurs in 10-20% of ED & ICU intubations.

1-2% of intubations performed in ED/ICU result in cardiac arrest!

This is an exceptionally dangerous procedure and preoxygenation is essential to keep patients safe.

But what’s the *BEST* way to preoxygenate?
2/
Most people use a non-rebreather oxygen mask, but because of its loose fit it often delivers much less than 100% FiO2.

NIV (“BiPAP”) delivers a higher FiO2 because of its tight fit. It also delivers PEEP & achieves a higher mean airway pressure which is theoretically helpful!
3/
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Read 15 tweets
Jun 12
Results from #PROTECTION presented #CCR24 & published @NEJM.
- DB RCT of amino acid infusion vs placebo in n=3511 people undergoing cardiac surgery w/ bypass.
- Reduced incidence of AKI (26.9% vs 31.7% NNT=20) & need for RRT (1.4% vs 1.9% NNT=200)

Potential game changer!

🧵
1/
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I work in a busy CVICU & I often see AKI following cardiac surgery.

Despite risk stratification & hemodynamic optimization, AKI remains one of the most common complications after cardiac surgery with bypass.

Even a modest reduction in AKI/CRRT would be great for my patients.
2/ From Nature reviews nephrology  https://www.nature.com/articles/nrneph.2017.119
During cardiac surgery w/ bypass, renal blood flow (RBF) is reduced dramatically. This causes injury, especially in susceptible individuals.

But what if we could use physiology to protect the kidneys?

Renal blood vessels dilate after a high protein meal increasing RBF & GFR!
3/ https://www.jtcvs.org/article/S0022-5223(18)33243-4/fulltext
Read 11 tweets
May 3
A slightly tricky blood gas case:

77 yo with respiratory distress, RR 30, SpO2 80% on non-rebreather at 15 lpm

CXR & TTE are unrevealing

pH 7.58 / PaCO2 24 / PaO2 >500 / HCO3 22

MetHb 0% CarboxyHb 0%

The ABG looks like this: Image
The answer is sulfhemoglobinemia.

Sulfhemoglobinemia is a *permanently* modified hemoglobin associated with exposure to TMP/SMX, dapsone, phenazopyridine, & other amino & nitro compounds.

It has an altered oxy-hemoglobin dissociation curve.

2/

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Sulfhemoglobinemia is easily confused with methemoglobinemia. Both have very dark colored blood & present with cyanosis. Diagnosis typically requires a specialized lab.

Spoiler: you may have heard that SulfHb is green. It isn’t really. You’re thinking of Vulcans’ blood.

3/
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Read 7 tweets

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