Nick Mark MD Profile picture
Mar 8, 2022 18 tweets 10 min read Read on X
Here’s a situation many of us have seen in the ICU or ED: “It looked like there was ST elevation on the monitor but when I took a 12 lead it was gone?!”

A STEMI went MIA? Here’s a #tweetorial all about why ST segments look different on monitors.

#FOAMed #FOAMcc
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First, here’s another great example of "disappearing ST elevation", from Dr. Smith’s ECG Blog @smithECGBlog

(If you don’t already you should definitely follow Dr Smith & bookmark his site; hqmeded-ecg.blogspot.com IMO it's the best site for ECGs; you can thank me later)
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In order to understand *WHY* the ST segment looks different, we need to know how an ECG works & understand just a little bit of electronics & math.
(Don't worry, I promise no equations or circuit diagrams 🤞)
3/
First, we need to understand how an ECG works:
We use a pair of electrodes to measure the difference in electrical potential between two points on the body. We call this pair a “lead".

For example the left and right arm form lead I.

This was true in 1911 & still is in 2022.
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But there’s a problem: NOISE

Muscle movement/shivering, breathing, baseline wander, & other artifacts can interfere with the EKG signal.

All these types of NOISE would make the EKG almost useless for continuous monitoring.

But fortunately there’s a solution: FILTERING.
5/ From: Sivaraks & Ratanamaha...
Modern ECG monitors use *FILTERS* to remove much of the NOISE.

A bandpass filter allows only certain frequencies to pass:
Blocking low frequencies (<0.5Hz) removes respiration & baseline wander
Blocking high frequencies (>40Hz) removes most muscle twitches & AC interference
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Summary:Bandpass filters remove low frequency (respiration, baseline wander) & high frequency noise (muscle twitches, AC interference, etc) so we get only a perfect clean ECG signal?

Sounds great right?

Well…there’s a catch: Removing NOISE alters the SIGNAL.
7/
To understand why FILTERS alters the signal, we need to review just a teeny bit of math:

It turns out that you can represent *any* complex waveform as a summation of simple sine waves.

For example, look how we can make a sawtooth wave by combining 15 sine waves together👇
8/
This means that even a complex ECG waveform can be made by combining a bunch of sinusoidal functions of different frequencies (or harmonics).

Check out how they Fourier transformed an ECG into harmonics then put those harmonics back together 👇
hindawi.com/journals/isrn/…
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🤓 Sidenote: the mathematical name for these sinusoidal functions is a phase vector, usually called a “phasor” for short
That means that when you get an ECG you are really just combining sinusoids, or you could say a “Set of Phasors to Sum”
💥Zing
I’ll show myself out…
10/
The problem is we *NEED* some of those high & low frequency sine waves to make a proper EKG waveform.

The bandpass filters that removed pesky noise also took out some of the signal.

➡️Thus Filtering alters the ST segments!
Checkout how a 0.5Hz filter alters the same ECG:
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🔑 Point: Because of ECG filters, the ST segment is unreliable on a *MONITORING* ECG
This is why you must always obtain a *DIAGNOSTIC* ECG to properly evaluate the ST segments.

(If I teach you only one thing, remember the memes!)
12/ ImageImage
Clinical 🥡:
MONITORING ECGs (boxes people are constantly attached to) are used continuously for *rhythm determination*
DIAGNOSTIC ECGs (the thing rolled in, often called “a 12 lead ECG”) should be used for detailed ECG interpretation including analysis of the ST segments
13/ ImageImage
In case you are wondering, this is why patients must “hold still” for diagnostic 12 lead ECGs but the monitoring ECG often looks OK despite movement.

This also explains the Hz number on the bottom left of every ECG printout.
14/ ImageImageImage
A few more details about filters in ECGs:
- *DIAGNOSTIC* ECGs are typically 0.05 to 150 Hz
- *MONITORING* ECGs are typically 0.67 to 40 Hz (sometimes 0.5 to 50 Hz); narrower frequency range means less noise but also less reliable ST segments.

medteq.net/article/2017/4…
15/
Some OR monitors have an even more filtered “surgery” mode (1-20 Hz) to remove electrical interference from Bovies

This highly filtered mode can cause some serious artifactual ST elevation as shown in this case report & reply by the manufacturer.
…-publications.onlinelibrary.wiley.com/doi/epdf/10.11…
16/ ImageImageImageImage
🥡 Summary:
-unlike diagnostic ECGs, monitoring ECGs are highly filtered to remove noise
-filtering removes noise but also alters the ST segment; don’t trust ST segments on monitoring mode ECGs!
-ALWAYS obtain a diagnostic 12 lead ECG to properly evaluate the ST segment
17/17
Bonus fact:
Modern Fancy monitors allow continuous ST segment monitoring.
These monitors measure STE/STD in realtime & display it as number.
The displayed waveform is still filtered so you can trust the numbers but NOT what the ST segment looks like.
If in doubt get a 12 lead. ImageImageImage

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More from @nickmmark

Apr 30
Shortly before 3am on June 4, 1993, a mechanic at Miami airport looked in the wheel well of a DC-8 cargo jet from Bogotá. He saw the body of a teenager, curled in a ball, wearing only a t-shirt and shorts and frozen like an "ice cube."

The first paramedic pronounced him dead. The second found a weak pulse.

Somehow he had just survived 5 hours at 35,000 feet without heat or air pressure.

This should have killed him three different ways.

A🧵& blog post on how he survived.
1/Image
At 35,000 ft, there are three simultaneous killers:
🫁 Hypoxia: PO₂ is ~37 mmHg, well below the consciousness threshold of ~60 mmHg. Most peopple lose consciousness is 15-30 seconds. Even fully acclimatized Everest summiteers (at 29,000) survive only by driving PaCO₂ to ~8 mmHg through maximal hyperventilation.

🥶 Hypothermia: Ambient temp is –55°C. Accidental hypothermia causes fatal arrhythmia below ~28°C core temp. The coldest recorded accidental hypothermia survivor (13.7°C) lived only because of ECMO.

💥 DCS: Barometric pressure 179 mmHg (23% of sea level). The risk of decompression sickness and nitrogen gas embolism approaches 100% above 30,000 ft without a pressure suit.

No reasonable physiologist, handed these parameters, would predict survival. Yet somehow a 17 year old stow-away survived all three.

2/
The key is that hypothermia and hypoxia are mutually protective. The mechanism:
1️⃣ Hypoxia disables the thermostat
The preoptic anterior hypothalamus is exquisitely sensitive to hypoxia. As PaO₂ falls during ascent, it loses the ability to defend core temperature. The body becomes poikilothermic: temperature tracks the environment and the stow-away gets cold without shivering.

2️⃣ Hypothermia suppresses VO₂
The Q10 for brain CMRO₂ is 2.2. By the time core temp hits ~27°C (threshold for unconsciousness), brain O₂ consumption is ~45% of baseline. Demand meets the catastrophically low supply.
Cardiac surgeons exploit this in deep hypothermic circulatory arrest (DHCA), cooling the brain to 15-18°C to permit operating on a bloodless field.
The stowaway essentially did this to himself!

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Read 7 tweets
Sep 5, 2025
Lots of news articles reporting "Smartphone use on the toilet increases risk of hemorrhoids" citing a small single center study.

Great headlines but also a textbook example of *reverse causation* - a common methodological flaw in observational studies

A 🧵 Image
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Reverse causation occurs when we flip the arrow of cause→effect.

Protopathic bias is a subtype: An exposure (often a treatment/behavior) is started because early symptoms are already present, making it look like the exposure caused the outcome.

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A common example of reverse causation/protopathic bias is increased inhaler use --> increased risk of asthma hospitalization.

Did the inhaler use cause the hospitalization?

No! The person was developing symptoms which is why they were using the inhaler...

More examples:

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Read 12 tweets
Aug 19, 2025
This is a fascinating case:

A 60 yo man presents with paranoia, new-onset facial acne & cherry angiomas, fatigue, insomnia, ataxia, and polydipsia.

He has an extremely unusual diet.🧂

His labs are👇 (note that anion gap!):

What could be going on?
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Turns out he was inspired by a conversation with chatGPT to eliminate all sodium chloride from his diet.

🧪 He decided to replace sodium chloride with sodium bromide instead.

This had some unusual effects…

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Bromide toxicity - or bromism - is extremely rare today, but it was once quite common.

Prior to modern alternatives, lithium and potassium bromide were widely used as sedatives, with frequent side effects.

At one point 5-10% of the psychiatric admission were due to bromide!
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Read 6 tweets
Jun 1, 2025
Well designed RCT shows patients randomized to an exercise program had substantially improved survival after adjuvant chemotherapy for colon cancer.
- 5 yr disease-free survival 80.3% vs
73.9% (HR 0.72)
- 8 yr overall survival 90.3% vs 83.2% (HR 0.63)

This is groundbreaking!
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Some deets on the CHALLENGE trial

A 55 center trial done over 15 years (2009-2024) that randomized n=889 people with resected colon cancer after adjuvant chemotherapy to either:
- participate in a structured exercise program
- or to receive health-education materials alone

2/
The intervention was pretty comprehensive:
Personal activity consultant (PACs) - essentially trainers - got to know the participant 1:1, introduced them to the gym and came up with personalized activity goals
Regular every 2 week sessions helped participants reach the goals

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Read 16 tweets
May 18, 2025
Tragic news today about former president Biden's prostate cancer diagnosis. I wish him well.

As someone who follows presidential health reporting, I noticed something odd: unlike his predecessors, Biden's physician's never reported PSA.

How to interpret this absence? A🧵
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There are two possibilities:
1️⃣ Biden’s PSA was never checked
2️⃣ Biden’s PSA was checked but it wasn't reported

Strictly speaking, not checking PSA could be a medically correct option. Whether or not to test PSA is a complex question and is not the topic of this thread.

2/
Like many VIPs, presidents tend to have excessive testing that is not always strictly evidence-based.

For example, Bush 43 had an exercise treadmill test and a TB test for no apparent reason.

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Read 13 tweets
May 4, 2025
In honor of #MayThe4thBeWithYou let's consider the most difficult airways in the Star Wars universe:

1. Darth Vader
Species: human
Vader presents several challenges: Vent dependent at baseline, airway burns from Mustafar, limited neck mobility.
Discuss GOC before saving him Image
2. Fodesinbeed Annodue
Species: Trog
All airways require teamwork, but intubating Fodesinbeed Annodue's two heads really will require two operators.
Consider double simultaneous awake fiberoptic intubation
Be sure to consent both heads. Image
You will never find a more wretched hive of scum & challenging airways than Mos Eisley (except maybe at Jabba's)

3.Greedo
Species: Rodian
Micrognathia, posterior airway, no nasal intubation, green skin so no pulse ox
Approach: VL + bronchoscope. Intubate quickly (shoot first) Image
Read 23 tweets

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