Here’s a situation many of us have seen in the ICU or ED: “It looked like there was ST elevation on the monitor but when I took a 12 lead it was gone?!”
A STEMI went MIA? Here’s a #tweetorial all about why ST segments look different on monitors.
First, here’s another great example of "disappearing ST elevation", from Dr. Smith’s ECG Blog @smithECGBlog
(If you don’t already you should definitely follow Dr Smith & bookmark his site; hqmeded-ecg.blogspot.com IMO it's the best site for ECGs; you can thank me later) 2/
In order to understand *WHY* the ST segment looks different, we need to know how an ECG works & understand just a little bit of electronics & math.
(Don't worry, I promise no equations or circuit diagrams 🤞)
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First, we need to understand how an ECG works:
We use a pair of electrodes to measure the difference in electrical potential between two points on the body. We call this pair a “lead".
For example the left and right arm form lead I.
This was true in 1911 & still is in 2022. 4/
But there’s a problem: NOISE
Muscle movement/shivering, breathing, baseline wander, & other artifacts can interfere with the EKG signal.
All these types of NOISE would make the EKG almost useless for continuous monitoring.
But fortunately there’s a solution: FILTERING. 5/
Modern ECG monitors use *FILTERS* to remove much of the NOISE.
A bandpass filter allows only certain frequencies to pass:
Blocking low frequencies (<0.5Hz) removes respiration & baseline wander
Blocking high frequencies (>40Hz) removes most muscle twitches & AC interference 6/
Summary:Bandpass filters remove low frequency (respiration, baseline wander) & high frequency noise (muscle twitches, AC interference, etc) so we get only a perfect clean ECG signal?
Sounds great right?
Well…there’s a catch: Removing NOISE alters the SIGNAL.
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To understand why FILTERS alters the signal, we need to review just a teeny bit of math:
It turns out that you can represent *any* complex waveform as a summation of simple sine waves.
For example, look how we can make a sawtooth wave by combining 15 sine waves together👇 8/
This means that even a complex ECG waveform can be made by combining a bunch of sinusoidal functions of different frequencies (or harmonics).
Check out how they Fourier transformed an ECG into harmonics then put those harmonics back together 👇 hindawi.com/journals/isrn/… 9/
🤓 Sidenote: the mathematical name for these sinusoidal functions is a phase vector, usually called a “phasor” for short
That means that when you get an ECG you are really just combining sinusoids, or you could say a “Set of Phasors to Sum”
💥Zing
I’ll show myself out… 10/
The problem is we *NEED* some of those high & low frequency sine waves to make a proper EKG waveform.
The bandpass filters that removed pesky noise also took out some of the signal.
➡️Thus Filtering alters the ST segments!
Checkout how a 0.5Hz filter alters the same ECG: 11/
🔑 Point: Because of ECG filters, the ST segment is unreliable on a *MONITORING* ECG
This is why you must always obtain a *DIAGNOSTIC* ECG to properly evaluate the ST segments.
(If I teach you only one thing, remember the memes!) 12/
Clinical 🥡:
MONITORING ECGs (boxes people are constantly attached to) are used continuously for *rhythm determination*
DIAGNOSTIC ECGs (the thing rolled in, often called “a 12 lead ECG”) should be used for detailed ECG interpretation including analysis of the ST segments 13/
In case you are wondering, this is why patients must “hold still” for diagnostic 12 lead ECGs but the monitoring ECG often looks OK despite movement.
This also explains the Hz number on the bottom left of every ECG printout. 14/
A few more details about filters in ECGs:
- *DIAGNOSTIC* ECGs are typically 0.05 to 150 Hz
- *MONITORING* ECGs are typically 0.67 to 40 Hz (sometimes 0.5 to 50 Hz); narrower frequency range means less noise but also less reliable ST segments.
🥡 Summary:
-unlike diagnostic ECGs, monitoring ECGs are highly filtered to remove noise
-filtering removes noise but also alters the ST segment; don’t trust ST segments on monitoring mode ECGs!
-ALWAYS obtain a diagnostic 12 lead ECG to properly evaluate the ST segment
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Bonus fact:
Modern Fancy monitors allow continuous ST segment monitoring.
These monitors measure STE/STD in realtime & display it as number.
The displayed waveform is still filtered so you can trust the numbers but NOT what the ST segment looks like.
If in doubt get a 12 lead.
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Well designed RCT shows patients randomized to an exercise program had substantially improved survival after adjuvant chemotherapy for colon cancer.
- 5 yr disease-free survival 80.3% vs
73.9% (HR 0.72)
- 8 yr overall survival 90.3% vs 83.2% (HR 0.63)
This is groundbreaking! 1/
Some deets on the CHALLENGE trial
A 55 center trial done over 15 years (2009-2024) that randomized n=889 people with resected colon cancer after adjuvant chemotherapy to either:
- participate in a structured exercise program
- or to receive health-education materials alone
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The intervention was pretty comprehensive:
Personal activity consultant (PACs) - essentially trainers - got to know the participant 1:1, introduced them to the gym and came up with personalized activity goals
Regular every 2 week sessions helped participants reach the goals
Tragic news today about former president Biden's prostate cancer diagnosis. I wish him well.
As someone who follows presidential health reporting, I noticed something odd: unlike his predecessors, Biden's physician's never reported PSA.
How to interpret this absence? A🧵 1/
There are two possibilities:
1️⃣ Biden’s PSA was never checked
2️⃣ Biden’s PSA was checked but it wasn't reported
Strictly speaking, not checking PSA could be a medically correct option. Whether or not to test PSA is a complex question and is not the topic of this thread.
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Like many VIPs, presidents tend to have excessive testing that is not always strictly evidence-based.
For example, Bush 43 had an exercise treadmill test and a TB test for no apparent reason.
In honor of #MayThe4thBeWithYou let's consider the most difficult airways in the Star Wars universe:
1. Darth Vader
Species: human
Vader presents several challenges: Vent dependent at baseline, airway burns from Mustafar, limited neck mobility.
Discuss GOC before saving him
2. Fodesinbeed Annodue
Species: Trog
All airways require teamwork, but intubating Fodesinbeed Annodue's two heads really will require two operators.
Consider double simultaneous awake fiberoptic intubation
Be sure to consent both heads.
You will never find a more wretched hive of scum & challenging airways than Mos Eisley (except maybe at Jabba's)
3.Greedo
Species: Rodian
Micrognathia, posterior airway, no nasal intubation, green skin so no pulse ox
Approach: VL + bronchoscope. Intubate quickly (shoot first)
Every year, there is a predictable spike in fatal car accidents, medical errors, & heart attacks.
It’s estimated that there are thousands of excess deaths, a 1% increase in energy consumption, & billions of dollars in lost GDP.
The cause? Daylight savings transitions.
🧵
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Earth's axis of rotation and orbital axis are not precisely aligned. The 23.5 degree difference - 'axis tilt' - gives us our seasons and a noticeable difference in day length over the course of the year.
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For millennia this seasonal variation was an accepted fact of life.
In 1895, George Hudson, a New Zealand entomologist, was annoyed that less afternoon light meant less time for bug collecting.
He realized that clocks could be adjusted seasonally to align with daylight.
Unlike other Trump moves, this is arguably GOOD news for researchers!
If the NIH budget is unchanged (a big if), this allocates more money to researchers; if you go from an indirect of 75% to 15% it means you can fund 3 grants instead of 2.
Between 1947 and 1965, indirect rates ranged from 8% to 25% of total direct costs. In 1965, Congress removed most caps. Since then indirects have steadily risen.
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A lot of indirects go to thing like depreciation of facilities not paying salaries of support staff.
This accounting can be a little misleading.
If donors build a new $400m building, the institution can depreciate it & “lose” $20m/year over 20 years. Indirects pay this.
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