Yan Leyfman, MD Profile picture
Mar 9 6 tweets 17 min read
Thank you to our Keynote Speakers from COAST-to-COAST for their insightful presentations & to the 8,752 participants who attended @MedNewsWeek Conference in February 2022. It was a pleasure learning from everyone.
I would also like to thank our great team that helped to make this event possible.
@etahmed @CParkMD @drysilay @LVento @lexyv717 @MedNewsWeek @evolusean_

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More from @YLeyfman

Mar 9
Study looking at the impact of vaccine misinformation found:

-66% of U.S. adults say they would be likely to recommend vaccinating a hypothetical 5-11 yr olds in their household who is eligible for the #Covid19 #vaccine.
-39% of the vaccinated-but-not-boosted hold high levels of misinformation about the effects and safety of #vaccines
-the more that unvaccinated adults worry about getting #long #Covid, the more likely they are to say they will get vaccinated
-40% of the #unvaccinated – or 9% of the total survey sample – are potentially persuadable to be #vaccinated

eurekalert.org/news-releases/…
Read 4 tweets
Mar 8
Study from @salkinstitute found that partial reprogramming using the #Yamanaka transcription factors (#Oct4, #Sox2, #Klf4 & #cMyc) for short periods of time:

-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.
-long-term partial reprogramming led to rejuvenating effects in different tissues, such as the #kidney & #skin, and at the #organismal level; duration of the treatment determined the extent of the beneficial effects.
-The rejuvenating effects were associated with a reversion of the #epigenetic clock and metabolic and #transcriptomic changes, including reduced expression of genes involved in the #inflammation, #senescence & #stressresponse pathways.

nature.com/articles/s4358…
Read 4 tweets
Mar 8
MedNews Week Conference - Infectious Disease & Gastroenterology - Dr. Paul Feuerstadt (Yale) twitter.com/i/broadcasts/1…
Happening now!

A discussion about Gastroenterology & the latest developments chronic diarrheal syndrome from one of GI’s global leaders-- Dr. Paul Feuerstadt from @Yale (@DrPaulGastro)

Youtube stream:

Clubhouse link: clubhouse.com/event/maWRBOp8…
Read 6 tweets
Mar 7
Study from #England looking at the impact of #SARSCoV2 on #brain #pathology in 785 UK Biobank participants (aged 51–81) imaged twice found:

-brain changes in the following regions:
--greater reduction in grey matter thickness and tissue-contrast in the orbitofrontal cortex & parahippocampal gyrus
--greater changes in markers of tissue damage in regions functionally-connected to the primary olfactory cortex
--greater reduction in global brain size.
- infected participants also showed on average larger #cognitive decline between the 2 timepoints
-these imaging and cognitive longitudinal effects were still seen after excluding the 15 cases who had been hospitalized.
Read 6 tweets

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