Yesterday I mentioned PRACTICAL MAGIC and one of my favorite poisoning tales, and it's been a few years and 5K followers since I last posted it, so I thought I'd re-up it. So settle in for a murder gone wrong and "Justin's Three Rules of Murder." A long 🧵.
I ❤️ Sandra Bullock. And I ❤️PRACTICAL MAGIC. It's a classic tale of "Girl meets boy, boy is an abusive serial killer who kidnaps the girl and her sister, sister poisons bad boy’s tequila with belladonna, bad boy dies. Throw in some magic for good measure." We’ve all been there.
Our tale starts with Heather and Kevin. They got married, bought a house, and had kids. Things were good until Kevin lost his job. To support them, Kevin worked two jobs, so he wasn't around much, and that caused stress and a lot of fighting.
So one night Heather goes to her best friend Mindi's house and they watch, you guessed it, PRACTICAL MAGIC. The movie must have resonated pretty hard with Heather because it gave her an idea.
She's gonna kill Kevin with belladonna, just like in the movie. And that breaks Justin's First Rule of Murder: 1. Don't get your plan from Hollywood.
Why not in this case? In the movie, Sandra Bullock spikes bad boy's tequila with a lot of belladonna - something Nicole Kidman used before to get him to sleep - and the dude dies. The problem? Belladonna doesn't work like that.
Atropa belladonna, known as belladonna or deadly nightshade, is toxic, but it isn't sedating like in the movie. Belladonna contains the alkaloids atropine and scopolamine, and in overdose amounts elicit delirium, hallucinations, and a lot of cardiac issues.
So her plan of Kevin quietly going nighty-night won't work. But she doesn't know this because she didn't consult me, and instead tells her plan to Mindi. That breaks Justin's Second Rule of Murder: 2. Two people can keep a secret if one of them is dead.
Heather plows ahead and buys belladonna. The problem? She bought 100 capsules of HOMEOPATHIC belladonna, containing ZERO atropine or scopolamine. She might as well have bought 100,000. And that breaks Justin's Third Rule of Murder: 3. Don’t homeopathically poison someone.
Again, Heather doesn't know this, because she never consulted me. Still, she took out $750K in life insurance on Kevin (🚩) and decided she'd add the "belladonna" to his mashed potato lunch, call him at work, and when he didn't answer, rush to his workplace to find him dead.
But this didn't happen. Why not? Because she broke ALL THREE OF MY RULES, that's why! Things went south went she gave the "belladonna" to her neighbor Diane to hold on to. Why? Who the hell knows. Diane is weirded out by it and calls Mindi. They compare notes.
Diane and Mindi agree that Heather is up to no good and that Kevin is in danger (not really, but they don't know that because they didn't consult me), so they decide to call the police. Not right away though, the next day. Why the next day? Who the hell knows.
So the police investigate and get Mindi to wear a wire. They hear Mindi talking to Heather about:
- the insurance money
- the "belladonna"
- all about mashed potatoes
- and Heather's affair . . . . . . . . with Mindi.
So Heather was arrested. The police didn't know it wouldn't work because they didn't consult with me either. Anyways, the police tell Kevin about the plot but he doesn't want to press charges. Love is weird, yo. Still, Heather was found guilty and sentenced to 10-years in prison.
But our story doesn't end here. Heather and Kevin write to each other every day. Why?
Kevin:
“Yeah, we all make mistakes...it is what it is.”
Heather:
“In one aspect I love him for it. But in the same breath, he must be completely insane.”
After her release from jail, their relationship fizzled. Probably because she wanted to murder him.
I have no idea what happened between Heather and Mindi, but I think their relationship ended, too. Probably because of the whole "I called the police on you" thing.
So that's the PRACTICAL MAGIC murder. Attempted murder. Attempted poorly murder. Attempted poorly was never gonna happen murder because you can't homeopathically murder someone. See: Rule 3, Justin's Rules of Murder.
So to recap Justin's Three Rules of Murder: 1. Don’t get your plan from Hollywood. 2. Two people can keep a secret if one of them is dead. 3. Don’t homeopathically poison someone.
And if you haven't seen PRACTICAL MAGIC, you should, because Sandra Bullock is perfect. Perfect 😍
p.s. I joke about how I wasn't consulted on the poisoning gone wrong, but please, for the love of dogs, don't do this. Someone actually contacted me once and wanted advice on how to poison someone and get away with it. They even told me why they wanted to do it.
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I haven't done any #PenAndInkPoison in a while - I've been busy - so here you go. Today we'll talk about a toxin with a significant history and mechanism of action, and also dabbles into conspiracy theories. I present to you T-2 MYCOTOXIN: OF FUNGAL TOXINS AND BEE POOP, a 🧵.
T-2 Mycotoxin is produced by species of the fungal genus Fusarium. They're essentially molds that grow in soils and affect plants. If you grow tomatoes that yellow, wither, and die in late summer, you've probably heard of "Fusarium wilt."
Back to T-2 Mycotoxin, it belongs to a class of chemical compounds called trichothecenes. One I've talked about before is VOMITOXIN, which affects wheat and can make you...vomit. T-2 Mycotoxin does the same.
A lesson in *reading the article* 🧵
I'm a simple person so funny titles amuse me:
"Blackout Brownie: A Final Dessert Case Study"
So I read the abstract and this jumped out at me "delta-9-THC present at >5,000 ng/mL in the decedent’s central blood." WHOA! academic.oup.com/jat/advance-ar…
Now, greater than 5,000 ng/mL is huge (for perspective, some states have per se driving limits of 5 ng/mL), so I'm sure this will garner attention from anti-cannabis folks. What will madden them is the case was signed out as a natural cause of death. This was the correct call.
When you read through the history of the case you wonder if she made some super-duper-special brownies, and then you see the results table. What gives? That's a huge disparity between central and peripheral blood. Huge. 5,070 vs 7.6.
Something different for Toxicology Thursday: OF PROHIBITION AND NICOTINE, a longish 🧵.
If you hang out here long enough you'll notice that people that deal with drugs, like forensic and clinical toxicologists, are generally opposed to the prohibition of drugs and substances.
Why is that? If something is deemed bad or unsafe, shouldn't getting rid of it, banning it entirely, solve the problem? In a word, no. Nature abhors a vacuum and will fill it, sometimes with something worse, whether we're talking about a drug, a gangster, or a politician.
The prime example was the prohibition of alcohol from 1920-1933. It was a social engineering attempt that turned into a mass poisoning. Deaths from bootleg alcohol containing methanol and worse flooded the U.S. For more, read @deborahblum's THE POISONERS HANDBOOK, it's excellent!
Ready for some #PenAndInkPoison?
For some reason, I like the poisons in our food. I should clarify: I like the poisons *nature* puts in our food. We all gotta eat, right?
So buckle up for a 🧵, for today I present you with something new: BONGKREKIC ACID
Have you ever had tempeh? It's an Indonesian food made from fermented soybeans. Tempeh is sold as a very firm cake and has a wonderful nutty, earthy flavor. It's common in vegetarian and vegan cooking. I like it a lot. [FoodCraftLab (CC BY-SA-2.0)]
So tempeh is a common, staple food, made from soybeans. On the island of Java, however, is a type of tempeh made from coconut called tempeh bongkrek. And it can be toxic. Toxic tempeh.
For some #PenAndInkPoison today I want to talk about thebaine, mentioned briefly yesterday when discussing laudanosine and papaverine. Morphine gets all the glory as an opium poppy alkaloid, but I'd argue that thebaine is much, much more important.
Thebaine is not used therapeutically but is used commercially in the synthesis of some of the most important opioids we have on the market today. In anywhere from 2 to 8 steps you can produce all of the opioids shown below - there are more, but these are the important ones.
On the right, we have the opioid agonists oxycodone, oxymorphone, hydrocodone, and hydromorphone. Hydrocodone is the most frequently prescribed opioid analgesic (pain reliever) in the U.S. We all know about oxycodone (Oxycontin). And hydromorphone is used a ton in hospitals.
It's Thursday! I hate Thursdays, it's a cruel reminder that it's not yet Friday. To help us feel better, let's look at how the world of nature's poisons can intersect with postmortem forensic toxicology. I present to you LAUDANSOSINE and PAPAVERINE.
Laudanosine and papaverine are minor alkaloids found in the opium poppy (Papaver somniferum), but they don't get near the attention of the heavy-hitter opiate morphine, which is made (rather simply) into heroin. Other alkaloids found in opium poppy are codeine and thebaine.
Laudanosine sounds very similar to laudanum, the opium tincture that was common in the 1800s. It was ~10% opium alkaloids, and when drunk, had the same effects of opiates/opioids today, like euphoria, but also the same side effects, namely respiratory depression and dependence.