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Prakash Gudsoorkar Profile picture
@gudnephron
Mar 25, 2022 • 11 tweets • 6 min read • Read on X
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Hot out of press.
"AKI in critically ill patients with cancer"

@ShrutiGkidney @BWHKidney @MGHKidneys @DanaFarber
@kdjhaveri @HofstraKidney
@CJASN
@onconephsociety
@UCincyMedicine @UCKidney @UCincyIM
#Onconephrology

Causes of AKI in pts with cancer in nutshell ⬇️
⭐️Phenotypes of AKI from monoclonal gammopathy
⭐️ Data suggest that patients with MGRS are at high risk for progression to kidney failure if not treated with clone-directed therapy (e.g., bortezomib)

Read more about it in the section "Monoclonal Gammopathies and AKI" ⬇️
⭐️Other etiologies of AKI in cancer
Hypercalcemia
Direct kidney parenchymal infiltration
Obstruction⬇️
⭐️Conventional chemoRx toxicities ⬇️
Prototype chemoRX AKI from Cisplatin : Mediated by apoptosis, inflammation, DNA and mitochondrial injury ⬇️
HSCT associated AKI
The flowchart sums it all ⬇️
AKI from targeted therapies.
check out the table which summarizes it. ⬇️
A brief synopsis of AKI from
-ImmunoRx
-CellularRx (CAR-T cell)
-TMA
-Hemodynamic causes
-TLS⬇️
To conclude
⭐️Precision medicine : need to have biomarkers to predict AKI on oncoRx agents
⭐️eg: CRP and urinary retinol binding protein in ICPi-AKI induced AIN
⭐️Can help to identify pseudo-AKI which can happen with drugs like PARP & CDK 4/6 inhibitors

@threadreaderapp
cjasn.asnjournals.org/content/early/…
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More from @gudnephron

Prakash Gudsoorkar Profile picture
Jul 9, 2022
We kept our promise

We are back with the 2 nd issue of Onconeph
#Onconephrology
12 🔥 articles
40+ authors
Great collaborative effort

@kdjhaveri
@MegSise
@CharuThakar
@ackdonline
@NKF_NephPros
@nkf
@onconephsociety
@UCKidney
@uofcincy
@UCincyMedicine
@ucincipress
🔥Our editorial speaks about the summary of the individual topics.
Paraproteinemia
TMA $
Na/K ⬇️⬆️in Ca
Palliative Rx
HSCT & kidney
Heme cancer & kidney
Paraneoplastic GN
Sickle cell ds
OncoSx and AKI
Anemia & cancer
Anti Ca Rx dosing in CKD
TxP Onconeph
🔥Kidney in dysproteinemia

Exhaustive review by @HerrmannMd @AkazukiNinaMD Dr Seshan
@MayoClinic @WeillCornell

👉Covers entire spectrum of kidney involvement in dysproteinemias
👉Excellent path images to support the manuscript.

VA by @Elena_Cervants
Read 16 tweets

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