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Mar 28 • 3 tweets • 4 min read
As a behavioral neurologist, how do I relate patient symptoms to brain imaging? What is a useful brain-behavior mapping?
Imhotep: Forget the brain, look at the heart!
Brodmann: Regional anatomy
Sherrington: Networks
New paper: How about a Global Functional State Space (GFSS)?
1/n
#NIHfundedADRC @MayoClinic propose a global information processing model for mental functions that links neuroanatomy, cognitive neuroscience and clinical neurology.
Thanks to our patients and caregivers! #EndAlz
Read @NatureComm rdcu.be/cJYV3
Thanks to @ettah
2/n
Explore the eigenbrains via neurovault neurovault.org/collections/AX…
Neurosynth GFSS decoding here chart-studio.plotly.com/~find37/79.emb…
Special thanks for related tools and inspiring ideas:
@chrisgorgo
@poldrack
@talyarkoni
@DanielMargulies
@jmacshine
3/n (more later)

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More from @DavidJonesBrain

David Jones Profile picture
Mar 30
1/n 🧵on the brief history of patterns seen on FDG-PET in Alzheimer's disease over the past 40 years. It's a story about a full circle convergence with the past 20 years of functional MRI. AD Heteromodal v primary cortex--> DMN--> AD--> principle gradient--> and the GFSS. #endalz
2/n “This, as well as other recent work, clearly suggests that the abnormal behavior of the demented subject may be related more to the disturbed functioning of surviving tissue than to loss of brain substance itself.” Friedland, et al. J Comput Assist Tomogr. 1983 Aug;7(4):590-8 Image
3/n "In contrast to the association cortices, energy metabolism in the primary cortices and subcortical structures is preserved relatively when compared to that in the parietotemporal and frontal association cortices." Minoshima, et al. Ann Neurol. 1997 Jul;42(1):85-94. Image
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