Pathophysiology of CKD Anemia and Strategies four Making Treatment Decisions with Steve Fishbane
COI: I’m a huge Fishbane fan 🤩 #NKFClinicals
COI: I’m a huge Fishbane fan 🤩 #NKFClinicals
Starting with a poll #NKFClinicals 
Spoiler, its hepcidin. #NKFClinicals
Stop saying CKD has erythropoietin deficiency. They have more! #NKFClinicals
Hepcidin the master regulator of iron #NKFClinicals
Hepcidin is regulated by iron and inflammation.
Inflammation inhibits other aspects of red cell production. #NKFClinicals
Inflammation inhibits other aspects of red cell production. #NKFClinicals
Renal Erythropoietin-producing (REP) cells are oxygen sensors in the the kidneys that control EPO production. Anemia and hypoxia stimulates EPO. In CKD there is disordered oxygen sensing. #NKFClinicals
Anemia is multi factorial and there is a TON of iron deficiency in CKD #NKFClinicals
It’s not the Hgb it’s the EPO (maybe, observational data) #NKFClinicals
40% of non-dialysis CKD receive a transfusion in the 2 years prior to ESRD. Results in increased anti-HLA antibodies. #NKFClinicals
Conclusions #NKFClinicals
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