Next up is Kirsten Johansen from U of Minnesota on Emerging therapies for CKD-related anemia. She starts with a question. This is a nightmare question and will not be participating. She mocks the audience for answering wrong. #NKFClinicals
Big list of trials so you can keep the trials straight #NKFClinicals
After showing data that the HIF stabilizers raise the hemoglobin she gets to the MACE data. First up Roxa. (Emoji, my addition) #NKFClinicals
Non-inferiority was not achieved with vadadustat but was achieved with daprodustat in non-dialysis patients #NKFClinicals
Onward to dialysis dependent. Once again the efficacy at raising the hemoglobin is clear and not in question….but MACE (major adverse cardiovascular events) is what we are interested in. #NKFClinicals
All three agents have demonstrated non-inferiority, but no signal for improved outcomes. #NKFClinicals
Interesting data looking at the + correlation between rate of Hgb rise and the risk of thromboembolic events. Hmmm. #NKFClinicals
HIF stabilizers may kill you but they sure improve the iron metabolism parameters #NKFClinicals
Brad is a fill in for Samir Parik
He has massive COI all over the place. Every drug. Every company. #NKFClinicals
Starts out with a case. Cr up from 0.6 to 1.2. 3500 mg of protein. Biopsy is WHO 4 and 5. She does not respond to MMF and steroids. Then does not respond to CYT. What to do?
Beware of getting on the roulette wheel of immunosuppression
We target proteinuria because reducing proteinuria is associated with good outcomes. Turns out, people whose kidneys heal have better outcomes. #NKFClinicals