Nayan @captainchloride Aurora calls his own number to speak on stopping RASi. #NKFClinicals
The debate comes from worrying about EGFR decline, hyperkalemia vs CV health, mortality benefit, kidney benefit #NKFClinicals
In CRIC in propensity matched evaluation of RASi users vs no RASI in CKD 4/5. No difference in outcomes, Kidney Medicine 2020 Aurora. #NKFClinicals
Now looking at RENAAL by Brenner et al. The patients with the highest Cr received the most protection from losartan. #NKFClinicals
Now discussing Hou 2006 NEJM. Single center. Compelling data that continuing benazepril preserved kidneys. Did not include diabetes. nejm.org/doi/full/10.10…
Fu et al JASN 2021
jasn.asnjournals.org/content/32/2/4…
Reduced mortality and MACE with continuing RASi, at the expense of increased risk of kidney. #NKFClinicals
jasn.asnjournals.org/content/32/2/4…
Reduced mortality and MACE with continuing RASi, at the expense of increased risk of kidney. #NKFClinicals
Now looking at heart failure in RENAAL, being on losartan was really good for heart failure. #NKFClinicals
Excellent presentations with great slides! #NKFClinicals
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