HaemSTAR 💙 Profile picture
May 5 6 tweets 6 min read
1/6
YESSSS!!!
Our second ever Flash Mob project is now published and is Open Access in @JTHjournal. In the largest ever, multicentre study of time to treatment in #TTP we found that diagnostic uncertainty was the most frequent reason for treatment delay. onlinelibrary.wiley.com/doi/full/10.11…
2/6
We audited practice against @BritSocHaem guidelines (onlinelibrary.wiley.com/doi/full/10.11…) and gathered data on 251 patients with #TTP across 80 sites thanks to 148 cited collaborators. WOW!!! Image
3/6
Only 65% patients received plasma exchange within 24h of presentation with the cause of delays being diagnostic uncertainty because of older age, higher Hb (>100g/l) & platelets (>30x10^9/l), and absence of RBC fragments on blood film. Lack of on-site PEX also contributed. Image
4/6
This work supports improving access to out-of-hours ADAMTS13 testing to enable earlier diagnosis in cases where there is uncertainty. We are told to start PEX before ADAMTS13 results are back but clearly this is not reflective of the realities of practice and tricky diagnoses
5/6
Well done to @TomboxaneA2 (@WestSuffolkNHS , @rorym21 (@UHP_NHS, now @gloshospitals), @PipNicolson (@ICVS_UoB), @doyley1_ (@GSTTnhs), & Marie Scully (@uclh) for all your hard work leading on this. Thanks to @bicops, @CRCTU and @TTP_Network for help, guidance, & hard work.
6/6
Do you want to get involved with HaemSTAR and be part of something powerful? You can get involved with our current Flash Mob audit of DOAC reversal agents now. Head to haemstar.org/rapido to find out more or DM us.

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