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May 14 โ€ข 54 tweets โ€ข 10 min read
Chapter 2.
"Biological Emergence and Inter-level Causation"
#BiologicalAutonomyMorenoMossio
1. Does the explanation of biological phenomena require appealing to ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐—ฐ๐—ฒ?
youtube.com/clip/UgkxjSerfโ€ฆ
In Chapter 1 we said that biological systems realise ๐™˜๐™ก๐™ค๐™จ๐™ช๐™ง๐™š: a causal regime ๐—ถ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—น๐—ฒ ๐—ฎ๐—ป๐—ฑ ๐—ฑ๐—ถ๐˜€๐˜๐—ถ๐—ป๐—ฐ๐˜ from those at work in other physical and chemical natural systems, and thus an ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐˜ property.
2. ๐—ง๐—ต๐—ฒ ๐—ฝ๐—ต๐—ถ๐—น๐—ผ๐˜€๐—ผ๐—ฝ๐—ต๐—ถ๐—ฐ๐—ฎ๐—น ๐—ฐ๐—ต๐—ฎ๐—น๐—น๐—ฒ๐—ป๐—ด๐—ฒ ๐˜๐—ผ ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐—ฐ๐—ฒ
Philosophical work on emergence began in the late 19th century, with British emergentism.
en.wikipedia.org/wiki/Emergentiโ€ฆ
A central challenge to the idea of emergence is articulated in Kimโ€™s ๐—ฒ๐˜…๐—ฐ๐—น๐˜‚๐˜€๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฟ๐—ด๐˜‚๐—บ๐—ฒ๐—ป๐˜
link.springer.com/article/10.100โ€ฆ
3. ๐—ž๐—ถ๐—บโ€™๐˜€ ๐—ฒ๐˜…๐—ฐ๐—น๐˜‚๐˜€๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฟ๐—ด๐˜‚๐—บ๐—ฒ๐—ป๐˜: definitions
For a whole W composed of parts Pi, each with properties Ni
๐—ฆ๐˜‚๐—ฝ๐—ฒ๐—ฟ๐˜ƒ๐—ฒ๐—ป๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ: If property M emerges from properties Ni, then M supervenes on Ni Image
๐—œ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—ถ๐—น๐—ถ๐˜๐˜†: Property M is emergent from a set of properties N1, โ€ฆ, Nn only if M is not functionally reducible with the set of the Ns as its realiser.
#definitions
4. ๐—ž๐—ถ๐—บโ€™๐˜€ ๐—ฒ๐˜…๐—ฐ๐—น๐˜‚๐˜€๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฟ๐—ด๐˜‚๐—บ๐—ฒ๐—ป๐˜: Statement

If an emergent property M is supervenient on some basal conditions P, and M is said to cause some effect, one may ask ๐™ฌ๐™๐™ฎ ๐™˜๐™–๐™ฃ๐™ฃ๐™ค๐™ฉ ๐™‹ ๐™™๐™ž๐™จ๐™ฅ๐™ก๐™–๐™˜๐™š ๐™ˆ as a cause of any putative effect of M?โ€ Image
5. ๐—ž๐—ถ๐—บโ€™๐˜€ ๐—ฒ๐˜…๐—ฐ๐—น๐˜‚๐˜€๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฟ๐—ด๐˜‚๐—บ๐—ฒ๐—ป๐˜: Problems
๐™˜๐™–๐™ช๐™จ๐™–๐™ก ๐™™๐™ง๐™–๐™ž๐™ฃ๐™–๐™œ๐™š: if the causal powers of an emergent entity can be reduced to those of its constituents, and if, as may indeed be the case, there is no โ€œrock-bottomโ€ level of reality, then...
...causal powers would "drain away into a bottomless pit and there would not be any causation anywhere". It'd be turtles over turtles all the way down...
additionally, if there were actually a rock-bottom, the exclusion argument would ๐—ณ๐—ผ๐—ฟ๐—ฐ๐—ฒ ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐˜๐—ถ๐˜ƒ๐—ฒ ๐—ฝ๐—ต๐˜†๐˜€๐—ถ๐—ฐ๐—ฎ๐—น๐—ถ๐˜€๐—บ, and any appeal to distinctively biological causal relations would be at best a heuristic tool...
6. Against Kim's exclusion argument, Moreno & Mossio provide an argument for closure being a specific kind of higher-level ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐˜ configuration, ๐—ผ๐—ป๐˜๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น๐—น๐˜† ๐—ถ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—น๐—ฒ.
Their argument is two-fold:
1) closure can be consistently understood as an ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐˜ ๐—ฟ๐—ฒ๐—ด๐—ถ๐—บ๐—ฒ ๐—ผ๐—ณ ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป all while staying strongly committed to ๐—บ๐—ผ๐—ป๐—ถ๐˜€๐—บ.
2) An emergent closed organisation ๐—ฑ๐—ผ๐—ฒ๐˜€๐—ปโ€™๐˜ ๐—ฟ๐—ฒ๐—พ๐˜‚๐—ถ๐—ฟ๐—ฒ ๐—ถ๐—ป๐˜๐—ฒ๐—ฟ-๐—น๐—ฒ๐˜ƒ๐—ฒ๐—น ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป (specifically, nested causation, i.e., causation from the whole into its own parts).
7. ๐—œ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—ถ๐—น๐—ถ๐˜๐˜† ๐˜ƒ๐—ฒ๐—ฟ๐˜€๐˜‚๐˜€ ๐—ป๐—ผ๐—ป-๐—ฑ๐—ฒ๐—ฟ๐—ถ๐˜ƒ๐—ฎ๐—ฏ๐—ถ๐—น๐—ถ๐˜๐˜†
Importantly, they argue that closure is ๐—ถ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—น๐—ฒ and not only ๐—ป๐—ผ๐—ป-๐—ฑ๐—ฒ๐—ฟ๐—ถ๐˜ƒ๐—ฎ๐—ฏ๐—น๐—ฒ (this will have consequences for distinguishing self-maintenance from closure)
A ๐—ป๐—ผ๐—ป-๐—ฑ๐—ฒ๐—ฟ๐—ถ๐˜ƒ๐—ฎ๐—ฏ๐—น๐—ฒ property of a whole is one that cannot be ๐ฉ๐ซ๐ž๐๐ข๐œ๐ญ๐ž๐ or ๐ž๐ฑ๐ฉ๐ฅ๐š๐ข๐ง๐ž๐ from the properties of its parts.
For example, the property of "containing" is not found on any of the sides of a box.
Non-derivability is ๐—ฒ๐—ฝ๐—ถ๐˜€๐˜๐—ฒ๐—บ๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น: it denotes a difficulty for predicting or explaining a property, whereas irreducibility is ๐—ผ๐—ป๐˜๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น: the entities produced are of a completely new kind.
Non-derivability is a characteristic of ๐—ฟ๐—ฒ๐˜€๐˜‚๐—น๐˜๐—ฎ๐—ป๐˜ properties, which are ๐—ฎ๐—ด๐—ด๐—ฟ๐—ฒ๐—ด๐—ฎ๐˜๐—ถ๐˜ƒ๐—ฒ, i.e., the whole possesses it at values that the parts do not.
Irreducible emergent properties are of a kind that only the whole possesses.
8. ๐—œ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—ถ๐—น๐—ถ๐˜๐˜† ๐—ฎ๐—ป๐—ฑ ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐—ฐ๐—ฒ
The core of Moreno & Mossio's argument for irreducible emergence of closure relies on distinguishing between ๐˜€๐˜‚๐—ฝ๐—ฒ๐—ฟ๐˜ƒ๐—ฒ๐—ป๐—ถ๐—ฒ๐—ป๐˜ ๐—ฏ๐—ฎ๐˜€๐—ฒ and ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐—ฐ๐—ฒ ๐—ฏ๐—ฎ๐˜€๐—ฒ of a property.
For this, they define ๐—ฟ๐—ฒ๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐—ฎ๐—น ๐˜€๐˜‚๐—ฝ๐—ฒ๐—ฟ๐˜ƒ๐—ฒ๐—ป๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ: a supervenience relation holding between the whole and a ๐—ฐ๐—ผ๐—ป๐—ณ๐—ถ๐—ด๐˜‚๐—ฟ๐—ฎ๐˜๐—ถ๐—ผ๐—ป of its constituents.
#definition
This ๐—ฟ๐—ฒ๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐—ฎ๐—น point of view argues that ๐—ฐ๐—ผ๐—ป๐—ณ๐—ถ๐—ด๐˜‚๐—ฟ๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐˜€ C have their own properties, distinct from those of their components (the parts P) Image
This is a ๐—ฐ๐—ผ๐—ป๐˜€๐˜๐—ถ๐˜๐˜‚๐˜๐—ถ๐˜ƒ๐—ฒ interpretation of relational supervenience: supervenient properties can be reduced to ๐—ฐ๐—ผ๐—ป๐—ณ๐—ถ๐—ด๐˜‚๐—ฟ๐—ฎ๐˜๐—ถ๐—ผ๐—ป properties (but not to the properties of the parts)
Moreno and Mossio then argue that emergent properties do not emerge from configurational properties, but between configurational properties and the properties of different categories and entities which do not belong to the configuration (the parts or individual processes)
9. ๐—ฆ๐˜‚๐—ฝ๐—ฒ๐—ฟ๐˜ƒ๐—ฒ๐—ป๐—ถ๐—ฒ๐—ป๐—ฐ๐—ฒ ๐—ฎ๐—ป๐—ฑ ๐—ฐ๐—ผ๐—ป๐˜€๐˜๐—ถ๐˜๐˜‚๐˜๐—ถ๐—ผ๐—ป
Kim argues that emergent properties are micro-based macro properties.
Here, the supervenient property M has causal powers relative to the parts Pi, but not relative to the properties S of the configurations of parts Ni
The supervenient property M is ๐—ฐ๐—ผ๐—ป๐˜€๐˜๐—ถ๐˜๐˜‚๐˜๐—ฒ๐—ฑ by the properties Si of the configurations โ€“ they are equivalent.
M&M's reply to Kim's exclusion argument
is that it is the relational properties Si of configurations which are genuinely emergent: the properties Si of the configuration C are irreducible to any entity that does not possess the same Si.
It is ๐—ฟ๐—ฒ๐—น๐—ฎ๐˜๐—ฒ๐—ฑ๐—ป๐—ฒ๐˜€๐˜€ ๐˜๐—ต๐—ฎ๐˜ ๐—ฏ๐—ฟ๐—ถ๐—ป๐—ด๐˜€ ๐—ผ๐—ป๐˜๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น ๐—ป๐—ผ๐˜ƒ๐—ฒ๐—น๐˜๐˜†, by stating that configurations may possess distinct causal powers. M is constituted by Si, and Si emerges from configurations of the parts Pi. Image
11. ๐—–๐—ผ๐—ป๐˜€๐˜๐—ฟ๐—ฎ๐—ถ๐—ป๐˜๐˜€ ๐—ฎ๐—ป๐—ฑ ๐—–๐—น๐—ผ๐˜€๐˜‚๐—ฟ๐—ฒ ๐—ฎ๐˜€ ๐—˜๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐˜ ๐——๐—ฒ๐˜๐—ฒ๐—ฟ๐—บ๐—ถ๐—ป๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐˜€
The reply refers to 3 kinds of emergent bases:

1. ๐—ฆ๐˜‚๐—ฏ๐˜€๐—ฒ๐˜ (Psset): The configuration C is emergent on any proper subset of the parts
2. ๐—ฆ๐˜‚๐—ฏ๐˜€๐˜๐—ฟ๐—ฎ๐˜๐—ฒ (Psstr): C is emergent on a collection of its constituents taken separately (potential ingredients)
3. ๐—ฆ๐˜‚๐—ฟ๐—ฟ๐—ผ๐˜‚๐—ป๐—ฑ๐—ถ๐—ป๐—ด๐˜€ (Psurr): C is emergent on external elements that do not constitute C, even if they share the same spatial localisation.
12. Constraints are configurations that exert causal actions on processes while being conserved with respect to them. In other terms:
1) At a relevant scale ๐œ, a constraint is a configuration Cconstr exerting a causal action on Psurr, which produces an observable difference between Psurr and Psurr^C (i.e., the surrounding parts alone, or under the effect of the constraint C)
2) At the same scale ๐œ, Cconstr is conserved throughout Psurr. Its emergent properties Si remain unaffected throughout Psurr.
A ๐—ฐ๐—น๐—ผ๐˜€๐—ฒ๐—ฑ organisation is a configuration Corg constituted of configurations Cconstr. Then:
1) closure is ๐—ถ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—น๐—ฒ to Psurr,
2) closure is ๐—ฒ๐—บ๐—ฒ๐—ฟ๐—ด๐—ฒ๐—ป๐˜ relative to Psstr,
14. ๐—œ๐—ป๐˜๐—ฒ๐—ฟ-๐—น๐—ฒ๐˜ƒ๐—ฒ๐—น ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป
After arguing that closure is an irreducible emergent property, M&M discuss the type of inter-level causation that can be at play.
Downward causation ๐—ผ๐—ป ๐—ฎ ๐—ฑ๐—ถ๐—ณ๐—ณ๐—ฒ๐—ฟ๐—ฒ๐—ป๐˜ ๐—ฒ๐—ป๐˜๐—ถ๐˜๐˜† located at a lower level is widespread and unproblematic. This definition applies straightforwardly to self-maintenance and closure. Weโ€™ll call this ๐—ป๐—ผ๐—ป-๐—ฟ๐—ฒ๐—ณ๐—น๐—ฒ๐˜…๐—ถ๐˜ƒ๐—ฒ ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป.
#definition
15. On the contrary, downward causation exerted by the system ๐—ผ๐—ป ๐—ถ๐˜๐˜€ ๐—ผ๐˜„๐—ป ๐—ฐ๐—ผ๐—ป๐˜€๐˜๐—ถ๐˜๐˜‚๐—ฒ๐—ป๐˜๐˜€ is more controversial. This is what Kim calls ๐—ฟ๐—ฒ๐—ณ๐—น๐—ฒ๐˜…๐—ถ๐˜ƒ๐—ฒ ๐—ฑ๐—ผ๐˜„๐—ป๐˜„๐—ฎ๐—ฟ๐—ฑ ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป.
16. There are various interpretations of reflexive causation.
๐—™๐—ผ๐—ฟ๐—บ๐—ฎ๐—น causation (like in Aristotle's formal cause), where the whole exerts a constraining action on its own constituents, may be the standard interpretation.
nbi.dk/~emmeche/coPubโ€ฆ
For ex., in a wheel rolling downhill no single molecule is enough to explain the rolling movement, only the form of the whole wheel can.
This is a case of ๐—ฒ๐—ฝ๐—ถ๐˜€๐˜๐—ฒ๐—บ๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น ๐—ป๐—ผ๐—ป-๐—ฑ๐—ฒ๐—ฟ๐—ถ๐˜ƒ๐—ฎ๐—ฏ๐—ถ๐—น๐—ถ๐˜๐˜†, and rolling can be seen as a ๐—ฟ๐—ฒ๐˜€๐˜‚๐—น๐˜๐—ฎ๐—ป๐˜ property.
17. Moreno & Mossio are interested, however, in the ๐—ผ๐—ป๐˜๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฐ๐—ฎ๐—น๐—น๐˜† ๐—ถ๐—ฟ๐—ฟ๐—ฒ๐—ฑ๐˜‚๐—ฐ๐—ถ๐—ฏ๐—น๐—ฒ type of reflexive downward causation, which they call ๐—ป๐—ฒ๐˜€๐˜๐—ฒ๐—ฑ ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป to be more precise.
18. They argue that ๐—ป๐—ฒ๐˜€๐˜๐—ฒ๐—ฑ ๐—ฐ๐—ฎ๐˜‚๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ถ๐˜€ ๐—ป๐—ผ๐˜ ๐—ฟ๐—ฒ๐—พ๐˜‚๐—ถ๐—ฟ๐—ฒ๐—ฑ in biology, because no nested causation can exist between an emergent property and its own supervenience base: config. properties Si do not produce M, and M does not exert downward causation on Si.
19. In particular, the closed organisation Corg does not exert causation on the whole network of constitutive constraints, and the whole network of constitutive contraints does not produce the closed organisation.
20. Letโ€™s consider the different emergent bases one by one and ask: is there need for nested causation between Corg and
1) ๐—ฆ๐˜‚๐—ฏ๐˜€๐—ฒ๐˜ (Psset)? No, since the properties of each Psset are already configurational, then redundant.
2) ๐—ฆ๐˜‚๐—ฏ๐˜€๐˜๐—ฟ๐—ฎ๐˜๐—ฒ (Psstr)? No, because the collection of constituents, taken without their configurational properties, is an abstract description which do not correspond to the way in which constituents are organised in the system
3) ๐—ฆ๐˜‚๐—ฟ๐—ฟ๐—ผ๐˜‚๐—ป๐—ฑ๐—ถ๐—ป๐—ด๐˜€ (Psurr)? No, because surroundings are by definition external to the configuration.
21. Moreno and Mossio conclude that constraints do exert causal powers, but not in the form of nested causation.
This has ๐Ÿฎ ๐—ฐ๐—ฟ๐˜‚๐—ฐ๐—ถ๐—ฎ๐—น ๐—ฐ๐—ผ๐—ป๐˜€๐—ฒ๐—พ๐˜‚๐—ฒ๐—ป๐—ฐ๐—ฒ๐˜€ for the interpretation of self-maintenance and closure:
1) ๐—ฆ๐—ฒ๐—น๐—ณ-๐—บ๐—ฎ๐—ถ๐—ป๐˜๐—ฒ๐—ป๐—ฎ๐—ป๐—ฐ๐—ฒ. Consider the case of Bรฉnard cells: an interpretation based on nested causation would claim that each cell constraints its own constituents.
youtube.com/clip/UgkxWXvRkโ€ฆ
But in relational terms, the cell ๐™ž๐™จ the configuration. One is tempted to think there's nested causation because the behaviour of each molecule within the cell is under-determined. This confuses epistemological non-derivability and ontological irreducibility.
2) ๐—–๐—น๐—ผ๐˜€๐˜‚๐—ฟ๐—ฒ: what would justify nested causation? Here, self-maintenance is realised collectively by a network of mutually dependent constraints. Constraints seem to act on processes which are already inside the system.
Although this considers the constrained processes as constituents of the organisation, they are not: in biological systems, the ๐—ฐ๐—ผ๐—ป๐˜€๐˜๐—ถ๐˜๐˜‚๐—ฒ๐—ป๐˜๐˜€ of the ๐—ผ๐—ฟ๐—ด๐—ฎ๐—ป๐—ถ๐˜€๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฎ๐—ฟ๐—ฒ ๐˜๐—ต๐—ฒ ๐—ฐ๐—ผ๐—ป๐˜€๐˜๐—ฟ๐—ฎ๐—ถ๐—ป๐˜๐˜€ ๐˜๐—ต๐—ฒ๐—บ๐˜€๐—ฒ๐—น๐˜ƒ๐—ฒ๐˜€, ๐—ป๐—ผ๐˜ ๐˜๐—ต๐—ฒ ๐—ฝ๐—ฟ๐—ผ๐—ฐ๐—ฒ๐˜€๐˜€๐—ฒ๐˜€.
22. In conclusion, constraints are configurations that by virtue of the relations existing between their own constituents possess emergent properties enabling them to exert distinctive causal powers on their surroundings.
23. And closure as an emergent and irreducible causal regime does not need to invoke nested causation.
24. End of Chapter 2.
Continue to Chapter 3!
the ideas here are similar to those put forward by people interested in high-order networks:
cambridge.org/core/elements/โ€ฆ
ping @_fernando_rosas: I'd love to know what you think about M&M's argument that nested causality (reflexive causality) is not necessary.

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More from @R3RT0

May 14
Chapter 1.
"Constraints and organisational closure"
#BiologicalAutonomyMorenoMossio
1. The particular type of causal regime at work in biological organisation is ๐˜พ๐™ก๐™ค๐™จ๐™ช๐™ง๐™š. It combines:
* An open thermodynamic regime, and
* A closed organisation regime of ๐™˜๐™ค๐™ฃ๐™จ๐™ฉ๐™ง๐™–๐™ž๐™ฃ๐™ฉ๐™จ Image
2. ๐˜ฝ๐™ž๐™ค๐™ก๐™ค๐™œ๐™ž๐™˜๐™–๐™ก ๐™™๐™š๐™ฉ๐™š๐™ง๐™ข๐™ž๐™ฃ๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™–๐™จ ๐™จ๐™š๐™ก๐™›-๐™˜๐™ค๐™ฃ๐™จ๐™ฉ๐™ง๐™–๐™ž๐™ฃ๐™ฉ
Closure can be defined in different contexts:

i. In general, a domain K is said to have closure if all operations defined in it remain within the same domain.
Read 35 tweets
May 14
"Life as autonomy" is an introductory section
#BiologicalAutonomyMorenoMossio
1. The main question of the book is how to characterise life?
A fundamental problem is the tension between the principle of continuity from inert to living, and the obvious differences between them.
2. Mainstream thinking emphasises the role of evolution and adaptation, i.e., the history of changes, but forgetting the organism, which becomes almost *dispensable*.
Read 15 tweets
Mar 20, 2020
Brain folds develop together with cytoarchitectonic regions and corticocortical connections. That folding results from a mechanical instability is now relatively well accepted. However, the pattern of these folds is still thought to reflect patterned gene expression #ohbmx
2
Indeed, a genetic program could encode regionalisation, connectivity and folding patterns. But what if folding *patterns* were of mechanical origin too? That would mean that mechanics have a causal role in the development and evolution of brain organisation! #ohbmx
3
One hint at the mechanical origin of folding patterns comes from observations made across primate species. Brains of phylogenetically distant species but with similar volume tend to have similar folding patterns despite their common ancestor being likely lissencephalic #ohbmx
Read 6 tweets

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