Rajeev Profile picture
May 19 12 tweets 5 min read
For the period, 1st January 2020 to 1st May 2022, a total of 10 545 cases (suspected) and 362 deaths of Monkeypox were recorded in the Democratic Republic of Congo .

For 2022 alone, up to week 17, DRC has reported 1238 cases with 57 deaths. Image
There is an issue of having laboratory-confirmed diagnosis in DRC due to limited resources, hence suspected cases are reported. Image
DRC is suffering the most complex and longest humanitarian crises in the world.

Over 27 million Congolese are acutely food insecure at Crisis (IPC Phase 3) and Emergency (IPC Phase 4) level -- the highest number worldwide.

reliefweb.int/report/democra…
Already 57 Monkeypox deaths in 2022 in the DRC. I was unable to find in death data for 2016 and 2017 Image
In 2017, after 39 years without reporting a case of Monkeypox, Nigeria suffered an outbreak.

From 2017 to 2022 (1 May), a total of 558 confirmed cases have been reported with 8 deaths Image
Here are suspected cases of Monkeypox reported in Nigeria from 2017 to 2022. Image
Nigeria have very good surveillance of Monkeypox and the Nigeria Centre for Disease Control (NCDC) regurlarly prepare reports.

The public dashboard can be accessed here: ncdc.gov.ng/data Image
For 2000–2019, the numbers for the Central African clade are based largely on suspected cases, per the reporting system by the DRC.

journals.plos.org/plosntds/artic… Image
A good paper describing the genetic and epidemiological characteristics of Nigerian and exported cases.
academic.oup.com/jid/article/22…
The United States reported a multistate outbreak in 2003, when a shipment of small mammals (rope squirrels, tree squirrels, African giant pouched rats, brush-tailed porcupines, dormice, and striped mice) from Ghana spread the virus to pet prairie dogs. Image
This forced the CDC and FDA to prohibit the importation of African rodents into USA.

cdc.gov/poxvirus/monke…
Will end this thread by quoting a snippet of @arimoin and team's paper published in 2010
pnas.org/doi/10.1073/pn… Image

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More from @Rajeev_The_King

Mar 15
Been a while since I did an update.

COVID-19 cases continue to decline in South Africa. Current 7-day moving average is slightly above the levels seen during the interwave periods
The rate of decline in cases over the last 2 months was much slower compared to similar points in time for the previous waves, possibly attributed to the rise in BA.2
Daily test positivity rates have also struggled to drop below 5%, indicating that there still is sufficient community transmission occurring.
Read 12 tweets
Jan 27
As of 26 Jan '22 in SA, there are currently 5709 COVID-19 in-patients aged 12 and over.

Here are the rates based on age, vaccination status, and type of hospital care.

For current general ward patients:
For current high care ward patients:

Note that there is only 1 high care ward patient in the 50-59 age group who is partially vaccinated, so you can see the rate for fully vaccinated in this age group is higher.
For current ICU patients:
Read 7 tweets
Dec 25, 2021
Current situation in the Western Cape:

Data is plotted by specimen received date up to 21 Dec '21
A welcomed slow down in the weekly growth rate in cases
Really concerning to see such high test positivity rates.

Data from WC dashboard

coronavirus.westerncape.gov.za/covid-19-dashb…
Read 4 tweets
Oct 10, 2021
Comparison of cumulative COVID-19 admissions per wave. Here the wave duration was defined from the time the country recorded a weekly incidence risk of 5 admissions per 100,000
population at the start of the wave to the same incidence risk at the end of the wave
The same hospitalisation incidence risk was used in this analysis of the first two waves carried out by the NICD

thelancet.com/journals/langl…
Cumulative hospital deaths for the same periods defined as above.
Read 8 tweets
Sep 3, 2021
From the latest Discovery Health data, a fully vaccinated individual has:

2 to 5x lower chances of being infected compared to an unvaccinated individual.

3 to 6x lower chances of being admitted to hospital from COVID-19 compared to an unvaccinated individual
3 to 10x lower chances of being admitted to the high care ward or ICU for COVID-19 compared to an unvaccinated individual.

At least 10x lower chances of dying from COVID-19 compared to an unvaccinated individual.
Read 4 tweets
Aug 11, 2021
Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

nejm.org/doi/full/10.10…
Accumulation of SARS-CoV-2 variants in three persistently positive pediatric and young adult patients with hematologic malignancies.

medrxiv.org/content/10.110…
Infection beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time

academic.oup.com/ofid/article/8…
Read 9 tweets

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