Casey Albin, MD Profile picture
May 31, 2022 26 tweets 15 min read Read on X
1/
I posted this case last week as a mystery case.

Lots of votes for dissection, which I agree would seem totally plausible. But...

This was not a dissection!

I left out some key details to make it more interesting

So... what *was* going on here?
#EmoryNCCTweetorials
2/
Before diving in, major shout outs to fellows @maness_caroline & @stevefylypiw & @b3ta_lacTAM for their help investigating!!🤩

So... best guess, where is the stroke?
Reminder, the symptoms:
👁️ Unilateral (Left) Miosis
😵‍💫Vertigo
😴 Altered consciousness
3/
Of these, the best guess is the lateral medulla.

✨Descending sympathetic fibers = Horner’s syndrome (miosis. Hard to eval ptosis, anhidrosis in this acute situation)
✨Vestibular nuclei = vertigo

(Lateral pons can cause these as well, but that wasn’t an option)
4/
But -- What about the altered consciousness??

The altered mental status was due to acute hypercarbic respiratory failure resulting from Ondine’s curse.

....What's this Ondine’s curse, you say...?

I have a whole #Tweetorial for you!
5/
The patient was significantly hypercarbic on the first ABG after intubation & continued to become apneic on SBT any time they slept.

This is due to the loss of respiration pattern generators in the lateral medulla (explained in more detail in the linked #tweetorial ⬆️)
6/
So, we have a suspected left lateral medullary stroke. The arterial supply is either the
🩸L vertebral artery or
🩸L PICA (usually a branch of the left vert)…

Back to the imaging:

The whole left side of the vertebral-basilar system is brighter than the right side. 🤔 Image
7/
Here’s a source image.

You can see highlighted that left vert opacifies and the right doesn’t.

In a dissection, the side that is dissected loses/has diminished opacification due to tear/associated thrombus.

*Vert distribution* pathology is often ipsilateral to the tear. Image
8/
Said differently, in this case, the stroke localizes ipsilateral to the side that opacifies with contrast.

Another fun recon to emphasis this.

Left = opacified, right = not so much.
⬇️⬇️⬇️ Image
9/
What is going on!?

Well, the big fact I left out in this case: the patient is in the CV-ICU on ECMO.

I know, I know. That’s really an important nugget of context! 😉 But for the fun of guessing...
10/
Next question: is why is the patient on ECMO?
Answer:
💔 Very advanced heart failure awaiting transplant

Which means the patient was on *VA-ECMO*
11/
In VA-ECMO the blood is removed from a venous cannula -> oxygenated -> returned to the arterial side to perfuse the rest of the body.

The ECMO circuit does the work of the 🫁 AND ♥️!
Image:link.springer.com/article/10.100… Image
12/
There are a lot of models and configurations of ECMO. We do a fair number of consults with the CV-team, and I still find the different set-ups confusing.

BUT, if you take away nothing else, remember that it is so helpful to understand the setup when doing a stroke eval!
13/
In this case the patient had a sport configuration:
a left subclavian venous cannula sent blood to the ECMO and a left axillary arterial cannula returned the blood

Similar to this but on the left.

ahajournals.org/doi/10.1161/CI… Image
14/
The reason this matters?

ECMO set-up and native heart function affect where the mixing cloud is!

🔁Mixing cloud = where does the blood returning from the circuit meets the blood that has been pumped from the patient’s native heart.
15/
Can we see this with contrast?
1⃣st, how does contrast circulate if the patient is on ECMO?

Most contrast is removed via the venous cannula ➡️ circulates through ECMO ➡️flows to the arterial side ➡️ travels to the rest of the body. Review: tinyurl.com/2p92h29a
16/
So most contrast re-enters the circulation from the ECMO device!

A quick scroll down the CTA demonstrates the contrast-rich blood (from ECMO) mixes with the contrast-poor blood (from native heart) in the aortic arch between the left common carotid and the left subclavian. Image
17/
This is tricky to visualize, right?

Fortunately, Tammy Lin (@b3ta_lacTAM), CV-ICU fellow and illustrator extraordinary made a beautiful figure to illustrate this!!

Dark red = pumped from heart (*note* this blood is not hypoxic! Lungs were fine)
Light red = pumped from ECMO Image
18/
So! The difference in opacification reflects the difference in the source of perfusion: contrast-rich from ECMO versus contrast-poor from native heart. Image
19/
In this case the brachiocephalic & left common carotid got perfusion directly from the heart.

The left subclavian (and vert) received perfusion from the ECMO circuit.

Meaning that of the 4 vessels perfusing the brain, only the left vert received direct-from-ECMO blood!
20/
So... where did the lateral medullary stroke come from??

The ECMO circuit.

Here, a few days later, you can see that something seems off at the base of the brainstem on the left. MRI would be better.. but #ECMO.
21/
Finally, it’s hard to time a perfusion study for a patient on ECMO, so it may also be the perfusion is attenuated because of poor timing… but here is the CTP. Image
22/
So perfectly watershed-y, which fits with how the blood is traveling to the anterior circulation & right posterior circulation from a failing heart (seems plausible it would have delayed transit times). Notably, there is no green in the the L cerebellum.

Rads-- thoughts?
23/
Ultimately, this was a challenging case for many reasons.

But some takeaways are:
1⃣ Always look for pupil asymmetry in a pt with AMS
2⃣ Stroke consult? Ask the CV people to review the ECMO circuitry with you
3⃣ When possible find the contrast-mixing cloud
24/
Thanks again to @maness_caroline, @stevefylypiw, @b3ta_lacTAM!! And @CajalButterfly for marveling at the images with me in real time.

Thoughts from ECMO and vascular gurus, did we miss anything?? @emcrit @rkchoi @ShadiYaghi2 @SVINJournal @drdangayach @ThinkingCC

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More from @caseyalbin

Dec 5
1/WE'RE BACK!
A 52 yo architect presents with a year of difficulty with memory & planning.

At work, she can't adapt to the new software.

Family notes she “forgot” steps in planning their annual vacations (“she didn’t book the hotel!”)

She's increasingly irritated & withdrawn. Image
2/
At work this had led to significant trouble and her manager has asked her to cut back on hours. She became increasingly anxious at work and irritated.

Her primary care doctor ordered an MRI which was reported as normal, particularly noting normal hippocampus volume.
3/
She underwent a neuropsychological assessment which underscored impairments in executive functions and cognitive flexibility.

However, she did poorly across many tests, including validity measures.
Read 14 tweets
Oct 23
1/
I once heard that a fever in the ICU was a "fever of too many origins."

Same can be said altered mental status/encephalopathy!

We put together a comprehensive approach to these challenging patients for #SeminarsinNeurology

A thread with our approach!
pubmed.ncbi.nlm.nih.gov/39137901/Image
2/
Start with 'is the AMS appropriate for the degree of critical illness?'

Often it is.

But do some digging, did the AMS precede the illness? ...Is it more than what you would expect?

Start with this flow chart⬇️ Image
3/
Is there AMS+ Fever+ headache/meningismus/photophobia or seizures??
(AMS + fever is usually septic encephalopathy)

Add the other findings= reasonable concern for CNS infection... start here⬇️; remember that CNS infections can cause ICP issues and infectious vasculopathy! Image
Read 5 tweets
Sep 20
1/
A 34 yo M presents with worsening confusion and seizures. He is febrile.

He is intubated and transferred to the NeuroICU.

A #continuumcase about a cause that’s probably low (not) on your DDx. Image
2/
I’m not even going to ask if you want an LP next, because “Fever, Status, AMS” = I wanted that LP way before this MRI.

You get one and the protein is 80, TNC #155, and glucose 80 (serum 147). Cultures and HSV PCR are pending.
3/
We are clearly in the realm of “inflammation.”

W/ the leptomeningeal enhancement, I’m not ruling bacterial meningitis out (empiric abx until culture back!), but the glucose is reassuringly high for that. Viral meningoencephalitis is a top consideration so bring on acyclovir!
Read 11 tweets
Sep 3
1/
A 75 yo M is brought in by his wife bc he is forgetful & “continues to drop things.”

She notes he's increasingly tearful, forgetful, and has an odd movement in his right hand.

MRI, EEG, LP were all normal.

In the room he keeps doing this with his face:
A #ContinuumCase Image
2/
What do you worry about most?
3/
Any of these would be reasonable. You could certainly frame this as a rapidly progressive dementia (BTW there is an excellent continuum article on the subject, this is one of the most visited on the website!)

journals.lww.com/continuum/full…
Read 12 tweets
Aug 29
1/
25-yo M p/w status epilepticus.

He has been paranoid and confused in the previous weeks.

MRI 👇. A large abdominal mass was identified on imaging.

You know what this is, but do you know why we treat it the way we do?

A #ContinuumCase on immunomodulators Image
2/
ok ok, everyone gets to vote on what's going on before we dive in on how we are going to treat it and why.

so what do you think?
3/
Anti-NMDA receptor encephalitis is caused by anti-neural antibodies against the cell surface proteins (in this cause the NMDA receptor) this causes in a stereotyped way a progression through
⭐️Psychosis
⭐️Seizures
⭐️Sympathetic storming
⭐️Orofacial dystonias
Read 18 tweets
Aug 20
1/
A 30 yo woman p/w 2 days of worsening paraparesis, left arm paresthesias and urinary retention. No change in vision.

Exam: hyperreflexic in the legs bilaterally+ sensory level at T10.

MRI C/T Spine + MRI Brain. And you find this … what to do for this #continuumcase? Image
2/
Just looking at the scan, history, and her demographic, what do you think?
3/
There are several things that might make you think MS:
➡️short segments of spinal cord lesions
➡️periventricular lesions.

However, the lesions look a bit funny, right?
Read 15 tweets

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