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Tatiana Prowell, MD

@tmprowell

Sep 21

NEW 📣 Nat’l study in #Sweden: 86% of people on sick leave due to #COVID19 in wave 1 of #pandemic still had symptoms 18m later, esp fatigue, cognition, sleep, movement. Risks higher if hospitalized or female. Vax didn’t exist then.
#MedTwitter #LongCovid

journals.sagepub.com/doi/10.1177/14…

The study also found nearly half of respondents also had problems w/ functioning in daily life 18 mos after they were infected w/ #COVID19. That is #LongCovid. This is a stunning number.

Sweden never had a full lockdown or mask mandate in wave 1. /2

#MedTwitter

With this approach, #COVID19 deaths were noticeably higher in #Sweden than in neighboring countries with more precautions. For example, see this graph from ABC based on a Johns Hopkins analysis of the region. The King said: “I think we have failed.” /3 au.news.yahoo.com/leaders-tragic…

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Tatiana Prowell, MD

@tmprowell

Sep 5

NEW Longest prospective study of #LongCovidKids: 1.3K kids who tested pos for #COVID19 were followed up to 3y. Of note, 89% of cases were “mild” & 9% had no symptoms, & 80% had zero doses of vaccine. Mix of variants, but most were Omicron then Delta. /1 thelancet.com/action/showPdf…

Sadly, 23% of kids had #LongCovid at 3 mos. While #s fell over time, 13% at 6 mos, 8% at 1 yr, 6% at 18 mos, & 7% at 2 yrs still had #LongCovid. This is tragic, both because it means that 1 in 12 kids are still suffering a year later, & most of those remain ill longer term. /2

Adolescents/teens were at MUCH greater risk than age <12, as were those infected by earlier variants. Females & those w/ comorbidities were also at slightly increased risk. Infection w/ orig variant resulted in ⬆️ autoimmune disease. Vaccination reduced risk of #LongCovid. /3

Read 10 tweets

Tatiana Prowell, MD

@tmprowell

Aug 28

#MedTwitter #NurseTwitter I have a small but important rant about medical gaslighting. I booked a pharmacy appt for vaccines for myself & my family. This evening when we all went to get them, the pharmacist said to me: “You only booked an appt for yourself, not the others.” 1/

No, I’m sure I booked all of us. I had actually booked a time & when it didn’t let me add others, I had cancelled & rescheduled for an hr later when they could take us all. I explained that to the pharmacist who could SEE the cancellation & rescheduling just as I said, but… /2

She then said “but you didn’t book anyone else, just you.” I insisted I did & described the lengthy process of having to re-enter all the same info (address, insurance info) over & over for each of us. She acknowledged that’s how their computer system makes you enter it… /3

Read 9 tweets

Tatiana Prowell, MD

@tmprowell

Jun 19

https://twitter.com/virusesimmunity/status/1803517986764103874

#MedTwitter

Great to see independent groups demonstrate that passive transfer of IgG from people w/ #longCovid (LC) to mice produces symptoms.

A few reactions:

👉 We need #clinicaltrials of repurposed drugs (& novel agents) to treat autoimmune disease now

BUT…

https://twitter.com/virusesimmunity/status/1803517986764103874

We have GOT to be able to identify patients w/ #longCovid who instead (or also) have persistent #SARSCoV2 &/or other reactivated virus. If we immunosuppress them (w/o treating 🦠), we can inadvertently harm them AND potentially abandon therapy that could help others w/ LC.

2/

Our ability to get products into the 🧠 will be more important than ever. That might be products that already cross the blood-brain barrier or novel product delivery strategies (devices to ferry a product across the BBB or strategies to open/close BBB like a drawbridge).

/3

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Tatiana Prowell, MD

@tmprowell

Apr 29

The postmortem exams of cats who died of #H5N1 #BirdFlu on dairy farms show devastating effects on the heart, lung, eyes, & brain.

‼️Do not consume raw (unpasteurized) dairy products.

#MedTwitter, 👀 at the screenshot. #AvianFlu #IDTwitter

wwwnc.cdc.gov/eid/article/30…

Because some are asking me to translate this, the very brief version is that massive inflammation & cell death occurred in heart, lungs, brain, & eyes of cats who drank unpasteurized milk from cows with #H5N1. In all, >50% of cats at that dairy farm died. #MedTwitter #BirdFlu

#H5N1 #birdflu is likewise very dangerous to us. More than 50% of the people who have tested positive for it globally in the last 20y have died. This is why #MedTwitter is watching closely. Finding increasing cases in humans & esp spreading btwn humans would set off alarms. 😷

Read 4 tweets

Tatiana Prowell, MD

@tmprowell

Apr 23

NEW: Prosp study in 225 pts w/ “mild” #COVID19 & future surgery or other procedures. People w/ viral RNA detection in tissue or🩸5.2 times more likely to dev #longCOVID symptoms (OR 5.2, 95% CI 2.6–10.1, p<0·0001). Higher copy #, higher odds. #MedTwitter
thelancet.com/journals/lanin…

Months after a positive #COVID19 test, viral RNA was found in 10 diff types of tissue, incl the liver, kidney, stomach, intestine, brain, blood vessel, lung, breast, skin, & thyroid + blood cells, which could explain the wide range of reported #longCovid symptoms. #MedTwitter /2

Growing evidence IMO that #COVID19 viral persistence contributes to many cases of #longCovid, though it’s prob not acting alone. Still learning how genetics, immune response, & reactivation of other viruses in us intersect, producing LC in some people & not others. #MedTwitter /3

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