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Jun 2 • 4 tweets • 3 min read
Happy Birthday to a man whose music has brought me so much joy. A composer who composed full scores for 1000 films all by himself. 7000 songs. No one like him. #Ilayaraja @rameshlaus @Meerasrini @thisisysr
Here are some clips of his music to enjoy. I had posted this last year.
The amazing chords in almost every song. I know for a fact this song for example, as most of his others, written out along with the melody without having to check and see how it sounds on a piano or guitar.
Another clip which I had posted a few days ago.

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More from @VincentRK

Vincent Rajkumar Profile picture
May 30
Myeloma FAQs for patients & clinicians. Please add additional questions.

1) Do you still recommend autologous stem cell transplant?

Yes. But for standard risk patients, delaying transplant is an option & gives similar survival (#ASH21 below). Look forward to #ASCO22 plenary.
2) What regimen do use for initial therapy?

VRd for most. Dara plus VRd for young high risk patients as pre transplant induction.

DRd is an alternative to VRd; but you need Dara plus Revlimid for many years. With VRd after 6-8 months it's only Revlimid. onlinelibrary.wiley.com/doi/abs/10.100…
3) What do you use for maintenance therapy?

Lenalidomide alone for standard risk. Lenalidomide plus bortezomib for high risk.
Read 20 tweets
Vincent Rajkumar Profile picture
May 28
Controlling COVID until the public is well vaccinated saves a huge number of lives.

See the huge difference between cases and deaths depending on when COVID occurred. 👇👇
The point is that yes with more transmissible variants countries that controlled Covid ended up with similar total numbers of cases as the US, UK, EU. But the fact they controlled COVID well for 2 years and opened up only after the public was vaccinated meant far fewer lives lost
Clearly the fact that highly transmissible variants were able to cause a massive amount of cases in a very short time in countries that previously controlled Covid shows how bad this virus is.
Read 7 tweets
Vincent Rajkumar Profile picture
May 28
Here are my Top 5 #ASCO22 @ASCO myeloma abstracts. #ASCO22VR
Links to the full abstract. As in the past, I left out studies where similar results were already presented or published before. Top 5 based on new data, clinical impact & methodology

Thread with countdown👇
#5 Risk adapted maintenance: Len for standard risk & Len plus Bortezomib for high risk gives outstanding results. #ASCO22 #ASCO22VR

Clinically important & updated data are excellent. @RujulParikh @SagarLonialMD @AjayNookaMD @WinshipAtEmory meetings.asco.org/abstracts-pres…
#4 CAR-T targeting GPRC5D. Doubt if one BCMA approach fails another BCMA approach will give significant benefit. These treatments are incredibly expensive. We need immunotherapy options that target something besides BCMA. @ZJU_China
#ASCO22 #ASCO22VR meetings.asco.org/abstracts-pres…
Read 11 tweets
Vincent Rajkumar Profile picture
May 18
The high cost of prescription drugs and what we need to do about it. Why nothing ever gets done.

A full 360 of the issue using cancer drugs and insulin as examples. Check it out.
1/
2/ I'm not an enemy of Pharma. I understand the value of innovation first hand. I've led numerous clinical trials, and continue to work with Pharma on new drugs.

My interest started with the recognition that every drug in my field is priced sky high. Unsustainable.👇
3/ Prescription drug prices are generally higher in the US than in every other country. Simple drugs. Complex drugs. New drugs. Old drugs. Everything.
Read 35 tweets
Vincent Rajkumar Profile picture
May 12
The Multiple Myelomas

There are 4 main types. Our recent paper gives a rough breakdown of each. nature.com/articles/s4140… @MayoMyeloma @BloodCancerJnl Image
The initial classification is based on non overlapping primary cytogenetic abnormalities. Patients who have both trisomies and an IgH translocation are classified based on the IgH translocation. @NatRevClinOncol nature.com/articles/s4157…
These major types of myeloma have some differences in clinical presentation and features, response to therapy, and prognosis.
Read 5 tweets
Vincent Rajkumar Profile picture
May 7
What caused this massive difference in COVID deaths?

Not lockdowns; not lack of democracy; not new treatments.

It was testing, contact tracing, avoiding crowds, masks, controlling new cases entering the country, leadership, clear strategy, & unified messaging to public. Image
In response to some of the quarries.

1) Age and obesity are not factors that affect whether someone gets Covid or not. They affect outcome if someone gets Covid. These countries controlled the number of Covid cases in their countries until omicron.
The more transmissible omicron variant did cause huge spikes in cases as it swept through just as they were relaxing precautions. But they managed to control Covid until the vast majority of the population was vaccinated, which is the strategy.
Read 6 tweets

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