Next up #gyncsm #ASCO22 Ruxolitinib
Ruxolitinib = JACK 1/2 inhibitor. The IL-6/JAK/STAT3 implicated in the survival of cancer stem like cells. Inhibition of this axis may improve the activity of chemotherapy.
SO... "dispositioned to neoadjuvant chemotherapy" seems really weird to say. These volunteers were recommended to NACT.
NRG007 study schema:
Who enrolled:
90.5% White
4.8% Black
4.8% race unknown
"patients who were BRCA mutated" should be restated as it's not a verb... "people with a documented BRCA mutation"
The slides on line for NRG-007 do not seem to coincide with what is being seen in the broadcast... There were 5 fatal toxicities (grade 5): 2 were in carbo/taxol treated and 3 in carbo/taxol/ruxolitinib....
Progression Free Survival was not statistically significantly changed. Overall survival not different.

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More from @drdonsdizon

Jun 6
Dr Veneziani up presenting the PESCO trial
Maveropepimut-S targets Survivin protein
Prior studies showed safety
Read 6 tweets
Jun 6
Hmmm. I am noticing that ex-US trials are not reporting race... Should this be a required element for @ASCO presentations?
Study design of MITO-23
MITO23 endpoints:
Primary: Overall Survival
Secondary: Progression Free Survival

Very interesting that OS was the primary endpoint I think...
Read 6 tweets
Jun 6
Study volunteers: 35% had platinum-refractory disease and 6% had primary platinum-refractory disease. 12% had a BRCA mutation
Continuous relacorilant treatment seemed more toxic to me: worse events of neuropathy and fatigue.
Read 5 tweets
Jun 6
This should be interesting as I am running a trial in clear cell cancer with colleagues @BrownOncology
Presented by my fellow Matt Hadfield at #ASCO22
This should be interesting as I am running a trial in clear cell cancer with colleagues @BrownOncology
Presented by my fellow Matt Hadfield at #ASCO22
Retrospective study suggests bevacizumab + chemo improved survival in people with ovarian clear cell carcinoma. Hypothesis generating for sure.
This study was a larger retrospective in Japan before and after Bev was approved.
Read 9 tweets
Jun 6
#gyncsm ATHENA-MONO volunteers
75% White, 22% Asian.
This will be a problem going forward. Volunteers on trials should represent the demographics of those who get the disease.
FWIW: Ref SEER (Cases per 100K persons)
ATHENA-MONO Progression free survival favors rucaparib over placebo in volunteers with HRD
Monk: Subgroup analyses all point towards benefit to rucaparib
Read 5 tweets
Jan 7
The Omicron surge has been truly devastating... for cancer centers. 🧵 1/9
Operating rooms are operating, but on a day by day basis as staff are sent elsewhere to cover. 2/9
I've found myself arguing with surgical colleagues but why "my patient" should go to the OR before "their patient" 3/9
Read 9 tweets

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