Very interesting that OS was the primary endpoint I think...
Nice CONSORT diagram showing who was included in what analysis:
Hmmm. I am noticing that ex-US trials are not reporting race... Should this be a required element for @ASCO presentations for #ASCO23 and beyond?
Prof. Lorusso: Trabectidin failed to demonstrate an increase in overall survial (same in progression free survival).
Finally, the appropriate way to use "fail" in the context of trial reporting.
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This should be interesting as I am running a trial in clear cell cancer with colleagues @BrownOncology
Presented by my fellow Matt Hadfield at #ASCO22
This should be interesting as I am running a trial in clear cell cancer with colleagues @BrownOncology
Presented by my fellow Matt Hadfield at #ASCO22
Retrospective study suggests bevacizumab + chemo improved survival in people with ovarian clear cell carcinoma. Hypothesis generating for sure.
This study was a larger retrospective in Japan before and after Bev was approved.
Ruxolitinib = JACK 1/2 inhibitor. The IL-6/JAK/STAT3 implicated in the survival of cancer stem like cells. Inhibition of this axis may improve the activity of chemotherapy.
SO... "dispositioned to neoadjuvant chemotherapy" seems really weird to say. These volunteers were recommended to NACT.
#gyncsm ATHENA-MONO volunteers
75% White, 22% Asian.
This will be a problem going forward. Volunteers on trials should represent the demographics of those who get the disease.
FWIW: Ref SEER (Cases per 100K persons)
ATHENA-MONO Progression free survival favors rucaparib over placebo in volunteers with HRD
Monk: Subgroup analyses all point towards benefit to rucaparib