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ShellPhishOne Profile picture
@SocialFuzzer
Jul 17, 2022 • 30 tweets • 14 min read • Read on X
News orgs are finally seeing the differentiators and benefits of Novavax.
Head to head study of Novavax vs mRNA and viral vector vaccines.
Additional video snippets from the July 19, 2022 CDC approval meeting for Novavax.
Great graphics that simplify how the different vaccines work from @michaelzlin. This shows that the traditional protein based vaccine from #Novavax is the least intrusive of the different vaccines being used today for Covid19. Image
Some people wonder what a heterogenous boost of different vaccines would look like. It seems that #Novavax with Pfizer could be a great combination!
#Novavax looks even better as a booster for Pfizer, Astra Zeneca, SinoPharm, SinoVax primed. Moderna isn't here but I'd expect similar great results as with the Pfizer mRNA primed.
Dr Paul Offit from the FDA vaccine committee is saying that boosting with #Novavax ancestral strain will be better than any bivalent vaccine that the mRNA companies will have. Novavax will have a bivalent cuz FDA requires it as mRNA vaccines can’t keep up.
Many experts ask for a pan-coronavirus vaccine but never dive deeper. #Novavax already does that. It reduces the antigenic distance of variants to give broad protection against future variants. We already have a pan-coronavirus vaccine people. Explainer: Image
Another thing #Novavax did is they further engineered the protein to make it harder for the S1 and S2 parts to break off from each other at the furin cleavage site. That's how it can better teach the immune system to achieve better durability against variants. S2 doesn’t mutate. Image
Why is S2 important? Here’s a great print that says it’s hugely important for a pan-coronavirus vaccine. The author of the paper says any mutations with S2 makes the virus non-viable. This essentially means #Novavax is a pan-coronavirus vaccine. science.org/doi/10.1126/sc… Image
#Novavax is the safest Covid19 vaccine you can get. My prediction is that it will become a household name for this reason in addition to the broad efficacy against current and future variants.
Novavax is already a pan-coronavirus vaccine for Covid19. Graphic explains how Novavax protects from ALL current & future variants with durability that is so sadly missing from existing mRNA vaccines. Great print on what's needed for a pan-coronavirus: science.org/doi/10.1126/sc… Image
When experts say we need a pan-coronavirus vaccine, it is actually more ambitious than Covid-19. They want it to protect against future corona viruses like SARS & MERS. Novavax is IT for Covid-19.
Glad to see that they are finally telling us this. What took so long? Yes- Novavax protects against future variants also!
telegraphindia.com/india/two-larg… Image
Great real world testimony on Novavax protection
Tests showed ability to stop transmissions with Novavax. It’s also pointing to their proprietary Matrix-M adjuvant as the reason. Though tests were conducted in mice, they expressed human ACE2 receptors which closely mimic human receptors. news-medical.net/news/20200702/… Image
It’s not possible to get efficacy for every variant without long clinical trial but you can extrapolate based on the immune response against different variants. The video provides guidance for extrapolating efficacy.
Novavax says they have evidence that they’re 90%+ effective against the latest Omicron variants and data to support that their durability for up to a year.
m.economictimes.com/news/india/nov… ImageImage
Dr James Hildreth @US_FDA VRBPAC meeting on Bivalents
“Most impressive data I saw today was presented by Dr Glen from Novavax” -After reviewing bivalent data from both Pfizer and Moderna. Why does FDA continue to slow their approvals?
NIAID funded test of different vaccines show Novavax is best overall for ALL variants. With BA.2.75 on the horizon, it seems Novavax is best for that. Researchers also say that variant specific boost isn't significantly better than original formulation. science.org/doi/10.1126/sc… Image
Great threads from Dr Lin about Novavax.
Not sure how I missed human clinical trials from Novavax that showed high IgG levels vs Omicron with just 2 shots. Goes to show they need better communications. It’s from their adolescent study that were done on humans and not nice like the mRNA vaccines. Image
This WaPo article describes how Novavax created their vaccine to protect against all variants. washingtonpost.com/creativegroup/… Image
Lots of experts seem to miss on why Novavax is able to achieve such broad protection against all variants. The answer is their Matrix-M secret sauce in addition to presenting conserved epitopes.
Dr Fauci talks about the low durability of mRNA and the hope of adjuvants to improve that durability. Did he get a sneak peak into Novavax data?
It's pointed out-NIAID test favored mRNA but Novavax still had the best results. For Novavax, plasma samples were not collected at peak titers & booster was after several months( because mRNA not durable)- not at the 8th month interval which was optimal. Image
This Thailand study for booster of Novavax after other primary series vaccines show great safety and immunogenicity against 2019 strain and BA.2. It confirms the NIAID study with added safety info. BA.2.75 will overtake BA.5 as the next VOC. medrxiv.org/content/10.110… Image
I'll reiterate the significance of mucosal immunity in the Novavax vaccine. Sterilizing immunity in upper respiratory AND lower respiratory track as Omicron likes to infect upper track. Astra Zeneca (ChAdOx1nCoV-19) can't do this.
ncbi.nlm.nih.gov/pmc/articles/P… Image
Here’s a breakdown from Michael Lin on why Novavax can broadly protect against all variants. This from middle of his thread but gems up and down this thread. Very good read.

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ShellPhishOne Profile picture
May 16, 2023
Finally a comparison of Novavax vs mRNA for protection in the upper airways. Only Novavax showed protection in the upper airways. While other studies evaluated peak protection, this one actually evaluated protection after 3 months. science.org/doi/10.1126/sc… Image
Neither mRNA nor viral vector vaccine from Astra Zeneca offer this kind of protection.
Great summary of the study from Daniel Park here.
Read 5 tweets
ShellPhishOne Profile picture
Mar 2, 2023
Two doses of Novavax is shown to be universal-like with superior antibody levels vs 3x mRNA in trial participants. It is broad spectrum so annual boosting is actually achievable. High durability of protein platform similar to Novavax vs mRNA is here: news.weill.cornell.edu/news/2022/12/e… Image
My previous thread for all things Novavax is here. Saves people research time as it includes studies and videos to explain why Novavax is better than mRNA vaccines.
This is another recommended from thread from Dr. Jeff Gilchrist for understanding the benefits of Novavax.
Read 7 tweets
ShellPhishOne Profile picture
Jan 26, 2023
This tweet says it all. He isn't about what's best as Novavax showed that it didn't need updates until XBB drifted as far away from OG as SARS is. But he ignores that and just wants mRNA to "win." His opinion is one-sided. He probably owns a ton of mRNA stocks.
Read 4 tweets
ShellPhishOne Profile picture
Aug 21, 2022
Great real world testimony on Novavax protection
Tests showed ability to stop transmissions with Novavax. It’s also pointing to their proprietary Matrix-M adjuvant as the reason. Though tests were conducted in mice, they expressed human ACE2 receptors which closely mimic human receptors. news-medical.net/news/20200702/… Image
It’s not possible to get efficacy for every variant without long clinical trial but you can extrapolate based on the immune response against different variants. The video provides guidance for extrapolating efficacy.
Read 27 tweets
ShellPhishOne Profile picture
Aug 5, 2022
#Novavax is the safest Covid19 vaccine you can get. My prediction is that it will become a household name for this reason in addition to the broad efficacy against current and future variants.
Novavax is already a pan-coronavirus vaccine for Covid19. Graphic explains how Novavax protects from ALL current & future variants with durability that is so sadly missing from existing mRNA vaccines. Great print on what's needed for a pan-coronavirus: science.org/doi/10.1126/sc… Image
When experts say we need a pan-coronavirus vaccine, it is actually more ambitious than Covid-19. They want it to protect against future corona viruses like SARS & MERS. Novavax is IT for Covid-19.
Read 27 tweets
ShellPhishOne Profile picture
Jun 30, 2022
#Novavax #UniversalCovidVaccine: More durable than mRNA vaccines with 90% efficacy after booster at 8 months without need to update for every new strain and far safer. They use conserved epitopes common in ALL variants. nejm.org/doi/full/10.10… Image
It can provide mucosal immunity which means sterilizing immunity. It's the only way to get out of our current predicament. We all need to send the message to our governments to reject the mRNA experiment that can't keep up with the high degree of mutations
The mRNA answer is to use an "updated" vaccine for Ba.1 that is already gone. Their proposal is to just use manufacturing data and skip trials. This means they want us to be guinea pigs for "updates". We are not guinea pigs. "Move fast and break fast" is not for public health.
Read 98 tweets

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