#Novavax is the safest Covid19 vaccine you can get. My prediction is that it will become a household name for this reason in addition to the broad efficacy against current and future variants.
https://twitter.com/SocialFuzzer/status/1555628370762682368
Novavax is already a pan-coronavirus vaccine for Covid19. Graphic explains how Novavax protects from ALL current & future variants with durability that is so sadly missing from existing mRNA vaccines. Great print on what's needed for a pan-coronavirus: science.org/doi/10.1126/sc… 
When experts say we need a pan-coronavirus vaccine, it is actually more ambitious than Covid-19. They want it to protect against future corona viruses like SARS & MERS. Novavax is IT for Covid-19.
Glad to see that they are finally telling us this. What took so long? Yes- Novavax protects against future variants also!
telegraphindia.com/india/two-larg…
telegraphindia.com/india/two-larg…
Great real world testimony on Novavax protection
https://twitter.com/SocialFuzzer/status/1561398430789824514
Tests showed ability to stop transmissions with Novavax. It’s also pointing to their proprietary Matrix-M adjuvant as the reason. Though tests were conducted in mice, they expressed human ACE2 receptors which closely mimic human receptors. news-medical.net/news/20200702/…
It’s not possible to get efficacy for every variant without long clinical trial but you can extrapolate based on the immune response against different variants. The video provides guidance for extrapolating efficacy.
https://twitter.com/socialfuzzer/status/1549495045786521600?s=21&t=WY5nIRx4vDsB0kVVZTELXg
Novavax says they have evidence that they’re 90%+ effective against the latest Omicron variants and data to support that their durability for up to a year.
m.economictimes.com/news/india/nov…
m.economictimes.com/news/india/nov…
Dr James Hildreth @US_FDA VRBPAC meeting on Bivalents
“Most impressive data I saw today was presented by Dr Glen from Novavax” -After reviewing bivalent data from both Pfizer and Moderna. Why does FDA continue to slow their approvals?
“Most impressive data I saw today was presented by Dr Glen from Novavax” -After reviewing bivalent data from both Pfizer and Moderna. Why does FDA continue to slow their approvals?
NIAID funded test of different vaccines show Novavax is best overall for ALL variants. With BA.2.75 on the horizon, it seems Novavax is best for that. Researchers also say that variant specific boost isn't significantly better than original formulation. science.org/doi/10.1126/sc…
Great threads from Dr Lin about Novavax.
https://twitter.com/SocialFuzzer/status/1566769816022630400
Not sure how I missed human clinical trials from Novavax that showed high IgG levels vs Omicron with just 2 shots. Goes to show they need better communications. It’s from their adolescent study that were done on humans and not nice like the mRNA vaccines.
https://twitter.com/novavax/status/1491889401340866565?s=21&t=6WTQK6Fjhi5fkF1zeNGKwA
This WaPo article describes how Novavax created their vaccine to protect against all variants. washingtonpost.com/creativegroup/…
Lots of experts seem to miss on why Novavax is able to achieve such broad protection against all variants. The answer is their Matrix-M secret sauce in addition to presenting conserved epitopes.
https://twitter.com/SocialFuzzer/status/1567330288472301571
Dr Fauci talks about the low durability of mRNA and the hope of adjuvants to improve that durability. Did he get a sneak peak into Novavax data?
It's pointed out-NIAID test favored mRNA but Novavax still had the best results. For Novavax, plasma samples were not collected at peak titers & booster was after several months( because mRNA not durable)- not at the 8th month interval which was optimal.
https://twitter.com/SocialFuzzer/status/1563932216710668288?s=20&t=2k3dII24wQggZzDo1PBiAw
This Thailand study for booster of Novavax after other primary series vaccines show great safety and immunogenicity against 2019 strain and BA.2. It confirms the NIAID study with added safety info. BA.2.75 will overtake BA.5 as the next VOC. medrxiv.org/content/10.110…
I'll reiterate the significance of mucosal immunity in the Novavax vaccine. Sterilizing immunity in upper respiratory AND lower respiratory track as Omicron likes to infect upper track. Astra Zeneca (ChAdOx1nCoV-19) can't do this.
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
Here’s a breakdown from Michael Lin on why Novavax can broadly protect against all variants. This from middle of his thread but gems up and down this thread. Very good read.
https://twitter.com/michaelzlin/status/1488988559927222276?s=46&t=mxsFdhwBRBq06Be7K1SFHw
Memory CD4+ T Cells from past corona virus infections have shown to cross react with SARS-CoV-2 epitopes. Novavax has also shown memory CD4+ T cell recognition of SARS-COV-2 epitopes from Omicron which means that unlike mRNA, it's capable of a broad response to variants long term
This means that Novavax exhibits pan-coronavirus vaccine behavior as the recognition of conserved epitopes from Omicron is consistent with the recognition of conserved epitopes by memory CD4+ T cells from previous infections. jci.org/articles/view/…
In human trials, Novavax showed that it was able to reduce antigenic distance of variants with a booster. Also showed IgG levels increased significantly to above the levels correlated with 95% vaccine efficacy. This confirmed what was presented to FDA. ir.novavax.com/2022-10-12-Nov…
SARS-CoV-2 infects CD4+ T cells & result in viral persistence. Novavax is best at inducing CD4+ T memory cells as it continues to increase even after 6 months. No doubt it provides broad&durable protection but how does this correlate to protection against LC or even help with LC?
FDA approved Novavax as heterologous booster. Human trials showed antibody levels above P3 trial of 90% efficacy. It's a huge concession by FDA admitting Novavax original formulation can protect against all variants while not allowing monovalent for mRNA. ir.novavax.com/2022-10-19-U-S…
Is FDA Vaccine Chief looking closer at Novavax as a workhorse vaccine here? There isn't anything else out there that aren't mRNA. Viral vectors are falling off the map which leaves just Novavax. He's at least conceding that mRNA vaccines aren't durable. statnews.com/2022/10/21/fda…
Both Novavax and J&J deleted the FC and mutated prolines which could lead to a better immune response. mRNA vaccines only mutated the prolines which could make a big difference here. Consider that J&J had 79% efficacy with just 1 shot if not for clotting. ncbi.nlm.nih.gov/pmc/articles/P…
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