Thyroid peroxidase (TPO) is an enzyme localized in the normal thyroid gland. TPO plays an important role in the production of thyroid hormones. A TPO antibody test detects antibodies against TPO.
TPO antibodies are checked in patients having primary hypothyroidism 1/n
TPO antibodies are checked in patients having primary hypothyroidism 1/n
to help establish underlying etiology. If TPO antibodies are positive, it suggests cause is autoimmune (eg. Hashimoto’s disease).
Some people with positive TPO antibodies may have normal thyroid function. It means that they are at risk of future thyroid dysfunction 2/n
Some people with positive TPO antibodies may have normal thyroid function. It means that they are at risk of future thyroid dysfunction 2/n
It is normally required to measure TPO Antibody only once when trying to find the etiology of thyroid dysfunction. The goal of Levothyroxine replacement in primary hypothyroidism is to achieve euthyroidism (normalization of TSH) 3/n
Patients with autoimmune hypothyroidism (Hashimoto's disase), TPO antibodies do not normalise. It is not required to measure them in followup (unlike TSH Receptor antibody in Graves’ disease - which I will cover in another thread)🧵 4/n
#Hypothyroidism
#Hypothyroidism
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